Publications by authors named "Ethan Hoffmann"

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Pharmacological characterization of SAGE-718, a novel positive allosteric modulator of N-methyl-d-aspartate receptors.
Jacob T Beckley, Teresa K Aman, Michael A Ackley, Tatiana M Kazdoba, Michael C Lewis, Ethan Hoffmann

Br J Pharmacol· April 2024

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Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose.
Jeffrey Wald, Anja Henningsson, Eva Hanze, Ethan Hoffmann, Haihong Li

Clin Pharmacokinet· September 2022

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SAGE-718: A First-in-Class -Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.
Matthew D Hill, Maria-Jesus Blanco, Francesco G Salituro, Zhu Bai, Jacob T Beckley, Ethan C Hoffmann

J Med Chem· July 2022

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA receptor positive allosteric modulator.
Alison L Althaus, Michael A Ackley, Gabriel M Belfort, Steven M Gee, Jing Dai, Ethan Hoffmann

Neuropharmacology· December 2020

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SAGE-217, A Novel GABA Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies.
Ethan Hoffmann, George G Nomikos, Inder Kaul, Shane Raines, Jeff Wald

Clin Pharmacokinet· January 2020

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Neuroactive Steroid -Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity.
Daniel S La, Francesco G Salituro, Gabriel Martinez Botella, Andrew M Griffin, Zhu Bai, Ethan C Hoffmann

J Med Chem· August 2019

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Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) Receptor.
Gabriel Martinez Botella, Francesco G Salituro, Boyd L Harrison, Richard T Beresis, Zhu Bai, Ethan Hoffmann

J Med Chem· September 2017

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Brexanolone as adjunctive therapy in super-refractory status epilepticus.
Eric S Rosenthal, Jan Claassen, Mark S Wainwright, Aatif M Husain, Henrikas Vaitkevicius, Ethan Hoffmann

Ann Neurol· September 2017

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Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus.
Radzi M Noh, Sowmya Venkatasubramanian, Shruti Daga, Jeremy Langrish, Nicholas L Mills, Ethan Hoffmann

Open Heart· September 2017

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Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.
Stephen Kanes, Helen Colquhoun, Handan Gunduz-Bruce, Shane Raines, Ryan Arnold, Ethan Hoffmann

Lancet· July 2017

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Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression.
Stephen J Kanes, Helen Colquhoun, James Doherty, Shane Raines, Ethan Hoffmann

Hum Psychopharmacol· March 2017

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Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus.
Sowmya Venkatasubramanian, Radzi M Noh, Shruti Daga, Jeremy P Langrish, Nicholas L Mills, Ethan Hoffmann

Open Heart· May 2016

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Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.
Bruce E Sands, Shashidhar Joshi, Jonathan Haddad, Johannes M Freudenberg, Deepa Elizabeth Oommen, Ethan Hoffmann

Inflamm Bowel Dis· March 2016

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Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure-Activity Relationships of Heterocyclic Substitution at C-21.
Gabriel Martinez Botella, Francesco G Salituro, Boyd L Harrison, Richard T Beresis, Zhu Bai, Ethan Hoffmann

J Med Chem· April 2015

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A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.
Arun Baksi, Oleg Kraydashenko, Alsu Zalevkaya, Roman Stets, Peter Elliott, Ethan Hoffmann

Br J Clin Pharmacol· July 2014

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Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers.
Sowmya Venkatasubramanian, Radzi Mohd Noh, Shruti Daga, Jeremy P Langrish, Nikhil V Joshi, Ethan Hoffmann

J Am Heart Assoc· June 2013

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Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.
Ethan Hoffmann, Jeff Wald, Siva Lavu, John Roberts, Claire Beaumont

Br J Clin Pharmacol· January 2013

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Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.
Tao Wang, Michelle L Lamb, Michael H Block, Audrey Molina Davies, Yongxin Han, Ethan Hoffmann

ACS Med Chem Lett· September 2012

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Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
Stephanos Ioannidis, Michelle L Lamb, Tao Wang, Lynsie Almeida, Michael H Block, Ethan Hoffmann

J Med Chem· January 2011

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Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway.
Kenneth Thress, Terry Macintyre, Haiyun Wang, Dave Whitston, Zhong-Ying Liu, Ethan Hoffmann

Mol Cancer Ther· July 2009

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Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.
Lei Jin, Heidi Galonek, Kristine Israelian, Wendy Choy, Michael Morrison, Ethan Hoffmann

Protein Sci· March 2009

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Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.
Tao Wang, Michelle L Lamb, David A Scott, Haixia Wang, Michael H Block, Ethan Hoffmann

J Med Chem· August 2008

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Synthesis and biological evaluation of novel cyclosporin a analogues: potential soft drugs for the treatment of autoimmune diseases.
Tsvetelina Lazarova, Jason S Chen, Blake Hamann, Jane M Kang, Daniela Homuth-Trombino, Ethan Hoffmann

J Med Chem· February 2003

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Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice.
Ruth Maron, Galina Sukhova, Ana-Maria Faria, Ethan Hoffmann, Francois Mach

Circulation· September 2002

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Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines.
Ruth Maron, Anthony J Slavin, Ethan Hoffmann, Yoshinori Komagata, Howard L Weiner

Int Immunol· February 2002

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