Publications by authors named "Ewald Edink"

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To Target or Not to Target Cyclic Nucleotide Phosphodiesterase 4A?
Yang Zheng, Susanne Schroeder, Georgi K Kanev, Sanaa S Botros, Samia William, Ewald Edink

Int J Mol Sci· April 2023

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From recipe to research: introducing undergraduate students to the nature of science using a hybrid practical course centred on drug discovery for neglected diseases.
Maikel Wijtmans, Ewald Edink, Oscar Pj van Linden, Yang Zheng, Antoni R Blaazer

Drug Discov Today· June 2021

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Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening.
Erik de Heuvel, Albert J Kooistra, Ewald Edink, Sjors van Klaveren, Jeffrey Stuijt

Front Chem· January 2021

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Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.
Erik de Heuvel, Abhimanyu K Singh, Ewald Edink, Tiffany van der Meer, Melanie van der Woude

Bioorg Med Chem· September 2019

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Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
Antoni R Blaazer, Abhimanyu K Singh, Erik de Heuvel, Ewald Edink, Kristina M Orrling

J Med Chem· May 2018

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Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
Johan Veerman, Toine van den Bergh, Kristina M Orrling, Chimed Jansen, Paul Cos, Ewald E Edink

Bioorg Med Chem· April 2016

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4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling.
Iuni M L Trist, Giulio Nannetti, Cristina Tintori, Anna Lucia Fallacara, Davide Deodato, Ewald Edink

J Med Chem· March 2016

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Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits.
Antoni R Blaazer, Kristina M Orrling, Anitha Shanmugham, Chimed Jansen, Louis Maes, Ewald Edink

J Biomol Screen· January 2015

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Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.
Mariano Stornaiuolo, Gerdien E De Kloe, Prakash Rucktooa, Alexander Fish, René van Elk, Ewald S Edink

Nat Commun· December 2013

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Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain.
Atilla Akdemir, Ewald Edink, Andrew J Thompson, Sarah C R Lummis, Albert J Kooistra

Bioorg Med Chem· October 2012

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Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.
Ewald Edink, Atilla Akdemir, Chimed Jansen, René van Elk, Obbe Zuiderveld

Bioorg Med Chem Lett· February 2012

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High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology.
Jeroen Kool, Ferry Heus, Gerdien de Kloe, Henk Lingeman, August B Smit, Ewald Edink

J Biomol Screen· September 2011

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Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.
Ewald Edink, Prakash Rucktooa, Kim Retra, Atilla Akdemir, Tariq Nahar

J Am Chem Soc· April 2011

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Conjugation of penicillin acylase with the reactive copolymer of N-isopropylacrylamide: a step toward a thermosensitive industrial biocatalyst.
Alexander E Ivanov, Ewald Edink, Ashok Kumar, Igor Yu Galaev, Alexander F Arendsen

Biotechnol Prog· June 2004

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