Publications by authors named "Ewan Pearson"

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Precision medicine in type 2 diabetes: targeting SGLT2 inhibitor treatment for kidney protection.
Thijs T Jansz, Katherine G Young, Rhian Hopkins, Andrew P McGovern, Beverley M Shields, Ewan R Pearson

Diabetologia· February 2026

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Validation of an algorithm for selection of SGLT2 and DPP4 inhibitor therapies in people with type 2 diabetes across major UK ethnicity groups: a retrospective cohort study.
Laura M Güdemann, Katherine G Young, Pedro Cardoso, Bilal A Mateen, Rury R Holman, Ewan R Pearson

Lancet Reg Health Eur· February 2026

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EndoCompass Project: Research Roadmap for Diabetes, Obesity, and Metabolism.
Chantal Mathieu, Manuela Meireles, Uberto Pagotto, Martin Wabitsch, Indraneel Banerjee, Ewan Pearson

Horm Res Paediatr· December 2025

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Exploring the genetic architecture of multiple long-term conditions using a genome-wide association study in the UK Biobank population.
Anand Thakarakkattil Narayanan Nair, Miles Witham, Avan A Sayer, Heather J Cordell, Ewan R Pearson

Sci Rep· December 2025

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Advancing rare disease therapeutics through digital twins: Opportunities in drug development and precision dosing.
Charlotte Maria Ursula Dette, Veronika Alberg, Simeon Rüdesheim, Dominik Selzer, Fatima Zahra Marok, Ewan R Pearson

Comput Struct Biotechnol J· December 2025

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One-year usage patterns of SGLT-2 inhibitors and GLP-1 receptor agonists in individuals with type 2 diabetes in a real-world population.
Louise A Donnelly, Katyayeni Singh, Rory J McCrimmon, Ewan R Pearson

Diabetes Obes Metab· November 2025

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Predictors of Initial and Sustained Glycemic and Weight Response to Tirzepatide: A Post Hoc Analysis of SURPASS-4.
Ewan R Pearson, Stefano Del Prato, Imre Pavo, Denise R Franco, Junyuan Zheng

Diabetes· October 2025

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Study protocol for an open-label, single-arm, mixed methods feasibility study of the MWIQ AI-powered decision support tool for diabetes management in GP practices.
Jane Dickson, Scott G Cunningham, Chris Sainsbury, Martin K Rutter, N Kanumilli, Ewan Pearson

BMJ Open· October 2025

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Updating a Clinical Prediction Model for Identifying Monogenic Diabetes to Include Both Clinical Features and Biomarkers.
Julieanne Knupp, Pedro Cardoso, Katherine G Young, Timothy J McDonald, Kashyap A Patel, Ewan R Pearson

Diabetes Care· October 2025

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EndoCompass project: research roadmap for diabetes, obesity, and metabolism.
Chantal Mathieu, Manuela Meireles, Uberto Pagotto, Martin Wabitsch, Indraneel Banerjee, Ewan Pearson

Eur J Endocrinol· October 2025

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Common genetic variants near and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial.
Josephine H Li, Lukasz Szczerbinski, Mark Tripputi, Haiyin Liu, Stella Nam, Ewan R Pearson

medRxiv· October 2025

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XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries.
Moneeza K Siddiqui, Theo Dupuis, Ranjit Mohan Anjana, Adem Y Dawed, Margherita Bigossi, Ewan R Pearson

Commun Med (Lond)· September 2025

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Evaluating prediction of short-term tolerability of five type 2 diabetes drug classes using routine clinical features: UK population-based study.
Pedro Cardoso, Katie G Young, Rhian Hopkins, Bilal A Mateen, Ewan R Pearson

Diabetes Obes Metab· August 2025

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Real-world initiation of continuous glucose monitoring (CGM) in adults with type 1 diabetes leads to increased body mass index - A brief report from IMI-SOPHIA study.
Jimena Soto-Hernaez, Rory J McCrimmon, Ewan R Pearson, Enrique Soto-Pedre

J Diabetes Complications· August 2025

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The influence of metformin treatment on the circulating proteome.
Ben Connolly, Laura McCreight, Roderick C Slieker, Khaled F Bedair, Louise Donnelly, Ewan R Pearson

EBioMedicine· August 2025

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Proteomic pathways across the ejection fraction spectrum in patients with heart failure and diabetes mellitus: an EXSCEL trial substudy.
Anthony E Peters, Maggie Nguyen, Jennifer B Green, Ewan R Pearson, John B Buse

Sci Rep· August 2025

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Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions.
Rebecca Darlay, Rupal L Shah, Richard M Dodds, Anand T N Nair, Ewan R Pearson

Genet Epidemiol· July 2025

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Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study.
Richard Howey, Jonathan Adam, Jerzy Adamski, Natalie N Atabaki, Søren Brunak, Ewan R Pearson

PLoS Genet· July 2025

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The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients-an IMI-DIRECT prospective study.
Liwei Lyu, Yong Fan, Josef Korbinian Vogt, Marc Clos-Garcia, Amelie Bonnefond, Ewan Pearson

Genome Med· July 2025

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Clinical and pharmacogenomic predictors of survival in tamoxifen treated breast cancer female patients: a real-world study.
Abdullah R Al-Matrafi, Khaled F Bedair, Sundararajan Srinivasan, Colin Palmer, Archie Campbell, Ewan R Pearson

BMC Cancer· June 2025

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A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study.
Natalie N Atabaki, Daniel E Coral, Hugo Pomares-Millan, Kieran Smith, Harry H Behjat, Ewan R Pearson

medRxiv· June 2025

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The Association Between Tirzepatide Versus Insulin Glargine and NT-proBNP Levels in People With Type 2 Diabetes With or at Elevated Risk for Cardiovascular Disease: Post hoc Analyses of SURPASS 4.
Naveed Sattar, Govinda J Weerakkody, Darren K McGuire, Mikhail N Kosiborod, Matthew M Y Lee, Ewan R Pearson

Circulation· May 2025

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Comparative Analysis of Type 2 Diabetes Prevalence and Clinical Profiles in Ethiopia and Nigeria.
Assefa Mulu Baye, Teferi Gedif Fenta, Suvi Karuranga, Ifeyinwa Dorothy Nnakenyi, Ekenechukwu Esther Young, Ewan R Pearson

J Diabetes· April 2025

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Performance of fasting plasma glucose for community-based screening of undiagnosed diabetes and pre-diabetes in sub-Saharan Africa.
Assefa Mulu Baye, Teferi Gedif Fenta, Suvi Karuranga, Ifeyinwa Dorothy Nnakenyi, Ekenechukwu Esther Young, Ewan R Pearson

Front Endocrinol (Lausanne)· April 2025

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Applications of AI in Predicting Drug Responses for Type 2 Diabetes.
Shilpa Garg, Robert Kitchen, Ramneek Gupta, Ewan Pearson

JMIR Diabetes· March 2025

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