Publications by authors named "Fakher Chabchoub"

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Multicomponent Synthesis of Multi-Target Quinazolines Modulating Cholinesterase, Oxidative Stress, and Amyloid Aggregation Activities for the Therapy of Alzheimer's Disease.
Saida Chakhari, José Marco-Contelles, Isabel Iriepa, Maria do Carmo Carreiras, Fakher Chabchoub

Molecules· September 2025

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Discovery of New Highly Potent Histamine H Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors.
Rim Malek, Kinga Sałat, Perle Totoson, Tadeusz Karcz, Bernard Refouvelet, Fakher Chabchoub

ACS Chem Neurosci· September 2024

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Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment.
Imen Dakhlaoui, Paul J Bernard, Diana Pietrzak, Alexey Simakov, Maciej Maj, Fakher Chabchoub

Int J Mol Sci· June 2023

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Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-]pyrimidines.
Manel Ben Hassen, Dhouha Msalbi, Badr Jismy, Fares Elghali, Sami Aifa, Fakher Chabchoub

Molecules· May 2023

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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J Bernard, Fakher Chabchoub

Molecules· December 2022

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Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties.
Emna Choura, Fares Elghali, Paul J Bernard, Dhouha Msalbi, José Marco-Contelles, Fakher Chabchoub

Molecules· November 2022

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Synthesis and biological assessment of new pyrimidopyrimidines as inhibitors of breast cancer resistance protein (ABCG2).
Imen Dakhlaoui, Sahel Vahdati, Emna Maalej, Fakher Chabchoub, Michael Wiese

Bioorg Chem· November 2021

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Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.
Óscar M Bautista-Aguilera, Lhassane Ismaili, Isabel Iriepa, Daniel Diez-Iriepa, Fakher Chabchoub

Chem Rec· January 2021

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Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.
Lazhar Zribi, Irene Pachòn-Angona, Òscar M Bautista-Aguilera, Daniel Diez-Iriepa, José Marco-Contelles, Fakher Chabchoub

Molecules· July 2020

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Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Fakher Chabchoub

J Enzyme Inhib Med Chem· December 2019

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New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.
Rim Malek, Raquel L Arribas, Alejandra Palomino-Antolin, Perle Totoson, Celine Demougeot, Fakher Chabchoub

J Med Chem· December 2019

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Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy.
Rim Malek, Maciej Maj, Artur Wnorowski, Krzysztof Jóźwiak, Helene Martin, Fakher Chabchoub

Bioorg Chem· October 2019

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Enzymatic synthesis of 1,3-dihydroxyphenylacetoyl-sn-glycerol: Optimization by response surface methodology and evaluation of its antioxidant and antibacterial activities.
Nadia Kharrat, Imen Aissa, Youssef Dgachi, Fatma Aloui, Fakher Chabchoub

Bioorg Chem· December 2017

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Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy.
Youssef Dgachi, Helène Martin, Alexandre Bonet, Mourad Chioua, Isabel Iriepa, Fakher Chabchoub

Future Med Chem· May 2017

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Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.
Youssef Dgachi, Olga Sokolov, Vincent Luzet, Justyna Godyń, Dawid Panek, Fakher Chabchoub

Eur J Med Chem· January 2017

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Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.
Youssef Dgachi, Lhassane Ismaili, Damijan Knez, Mohamed Benchekroun, Hélène Martin, Fakher Chabchoub

ChemMedChem· June 2016

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Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Youssef Dgachi, Oscar M Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Fakher Chabchoub

Molecules· May 2016

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Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease.
Oussama Cherif, Fatma Allouche, Fakher Chabchoub, Mourad Chioua, Elena Soriano

Future Med Chem· August 2015

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Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: anti-inflammatory agents with gastroprotective effect in rats.
Amine Karoui, Fatma Allouche, Monia Deghrigue, Asma Agrebi, Abderrahman Bouraoui, Fakher Chabchoub

Med Chem Res· September 2013

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Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease.
Mario Esquivias-Pérez, Emna Maalej, Alejandro Romero, Fakher Chabchoub, Abdelouahid Samadi

Chem Res Toxicol· June 2013

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Synthesis of aminocyanopyrazoles via a multi-component reaction and anti-carbonic anhydrase inhibitory activity of their sulfamide derivatives against cytosolic and transmembrane isoforms.
Fatma Allouche, Fakher Chabchoub, Fabrizio Carta, Claudiu T Supuran

J Enzyme Inhib Med Chem· April 2013

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Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Emna Maalej, Fakher Chabchoub, María Jesús Oset-Gasque, Mario Esquivias-Pérez, María P González

Eur J Med Chem· August 2012

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Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.
Emna Maalej, Fakher Chabchoub, Abdelouahid Samadi, Cristóbal de los Ríos, Almudena Perona

Bioorg Med Chem Lett· April 2011

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Synthesis of 6-amino-5-cyano-1,4-disubstituted-2(1H)-pyrimidinones via copper-(I)-catalyzed alkyne-azide 'click chemistry' and their reactivity.
Ennaji Najahi, Jan Sudor, Fakher Chabchoub, Françoise Nepveu, Fethi Zribi

Molecules· December 2010

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Ethyl 6-amino-5-cyano-4-isopropyl-2-methyl-4H-pyran-3-carboxyl-ate.
Mehdi Messaâd, Besma Hamdi, Fakher Chabchoub, Abdelhamid Ben Salah, Mansour Salem

Acta Crystallogr Sect E Struct Rep Online· December 2008

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