Publications by authors named "Fernando Donate"

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The Selective Estrogen Receptor Degrader ZN-c5 Has Broad Anti-Tumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Jianhui Ma, Sayee Hegde, Masha Sergeeva, Binita Chakraborty, Suzanne E Wardell

Mol Cancer Ther· December 2025

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In vitro and in vivo efficacy of an anti-CD203c conjugated antibody (AGS-16C3F) in mouse models of advanced systemic mastocytosis.
Yanyan Zhang, Ghaith Wedeh, Liang He, Monika Wittner, Florian Beghi

Blood Adv· February 2019

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Phase I Trials of Anti-ENPP3 Antibody-Drug Conjugates in Advanced Refractory Renal Cell Carcinomas.
John A Thompson, Robert J Motzer, Ana M Molina, Toni K Choueiri, Elisabeth I Heath

Clin Cancer Res· September 2018

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Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates.
Hui Zhao, John Atkinson, Sara Gulesserian, Zhilan Zeng, Jenny Nater

Cancer Res· April 2018

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A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise.
Hui Zhao, Sara Gulesserian, Maria Christina Malinao, Sathish Kumar Ganesan, James Song

Mol Cancer Ther· September 2017

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Inhibition of Megakaryocyte Differentiation by Antibody-Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia.
Hui Zhao, Sara Gulesserian, Sathish Kumar Ganesan, Jimmy Ou, Karen Morrison

Mol Cancer Ther· September 2017

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The Discovery and Preclinical Development of ASG-5ME, an Antibody-Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer.
Michael Mattie, Arthur Raitano, Kendall Morrison, Karen Morrison, Zili An

Mol Cancer Ther· November 2016

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Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker.
Kendall Morrison, Pia M Challita-Eid, Arthur Raitano, Zili An, Peng Yang

Mol Cancer Ther· June 2016

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Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models.
Pia M Challita-Eid, Daulet Satpayev, Peng Yang, Zili An, Karen Morrison

Cancer Res· May 2016

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AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma.
Fernando Doñate, Arthur Raitano, Kendall Morrison, Zili An, Linnette Capo

Clin Cancer Res· April 2016

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AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML.
Daniel S Pereira, Claudia I Guevara, Liqing Jin, Nathan Mbong, Alla Verlinsky

Mol Cancer Ther· July 2015

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Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM).
Xiang Xu, Yuan Cai, Ying Wei, Fernando Donate, Jose Juarez

PLoS One· October 2014

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The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.
Christopher P Guise, Maria R Abbattista, Rachelle S Singleton, Samuel D Holford, Joanna Connolly

Cancer Res· February 2010

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Redox-related antimelanoma activity of ATN-224.
Valerie Trapp, Kristy Lee, Fernando Doñate, Andrew P Mazar, John P Fruehauf

Melanoma Res· December 2009

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Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors.
Sarah A Lowndes, Avril Adams, Anthony Timms, Nita Fisher, Jon Smythe, Fernando Donate

Clin Cancer Res· November 2008

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Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.
Jose C Juarez, Mari Manuia, Mark E Burnett, Oscar Betancourt, Benoit Boivin

Proc Natl Acad Sci U S A· May 2008

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Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth.
Fernando Doñate, Graham C Parry, Yuval Shaked, Harvey Hensley, Xiaojun Guan

Clin Cancer Res· April 2008

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Angiogenesis blockade as a new therapeutic approach to experimental colitis.
Silvio Danese, Miquel Sans, David M Spencer, Ivy Beck, Fernando Doñate

Gut· June 2007

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Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase.
Amy L Allan, Patricia L Gladstone, Melissa L P Price, Stephanie A Hopkins, Jose C Juarez

J Med Chem· December 2006

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A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo.
Parisa Khalili, Ani Arakelian, Gaoping Chen, Marian L Plunkett, Ivy Beck

Mol Cancer Ther· September 2006

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Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1.
Jose C Juarez, Oscar Betancourt, Steven R Pirie-Shepherd, Xiaojun Guan, Melissa L Price

Clin Cancer Res· August 2006

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Inhibition of angiogenesis by cleaved high molecular weight kininogen (HKa) and HKa domain 5.
Keith R McCrae, Fernando Doñate, Sergei Merkulov, Danyu Sun, Xiaoping Qi

Curr Cancer Drug Targets· November 2005

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Extracellular tropomyosin: a novel common pathway target for anti-angiogenic therapy.
Fernando Doñate, Keith McCrae, David E Shaw, Andrew P Mazar

Curr Cancer Drug Targets· November 2004

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Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells.
Xiaojun Guan, Jose C Juarez, Xiaoping Qi, Natalya V Shipulina, David E Shaw

Thromb Haemost· August 2004

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Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities.
Fernando Doñate, Jose C Juarez, Xiaojun Guan, Natalya V Shipulina, Marian L Plunkett

Cancer Res· August 2004

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