Publications by authors named "Rachelle S Singleton"

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OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
Rachelle S Singleton, Phebee Liu-Yi, Fabio Formenti, Wei Ge, Rok Sekirnik

Proc Natl Acad Sci U S A· March 2014

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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
Norma Masson, Rachelle S Singleton, Rok Sekirnik, David C Trudgian, Lucy J Ambrose

EMBO Rep· March 2012

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Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
Rachelle S Singleton, David C Trudgian, Roman Fischer, Benedikt M Kessler, Peter J Ratcliffe

J Biol Chem· September 2011

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The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.
Christopher P Guise, Maria R Abbattista, Rachelle S Singleton, Samuel D Holford, Joanna Connolly

Cancer Res· February 2010

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DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.
Rachelle S Singleton, Christopher P Guise, Dianne M Ferry, Susan M Pullen, Mary J Dorie

Cancer Res· May 2009

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Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.
Adam V Patterson, Dianne M Ferry, Shelley J Edmunds, Yongchuan Gu, Rachelle S Singleton

Clin Cancer Res· July 2007

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