Publications by authors named "Susan M Pullen"

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Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides.
Robert F Anderson, Pooja Yadav, Sujata S Shinde, Cho R Hong, Susan M Pullen

Chem Res Toxicol· August 2016

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Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.
Maria R Abbattista, Stephen M F Jamieson, Yongchuan Gu, Jennifer E Nickel, Susan M Pullen

Cancer Biol Ther· January 2016

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Dual targeting of hypoxia and homologous recombination repair dysfunction in triple-negative breast cancer.
Francis W Hunter, Huai-Ling Hsu, Jiechuang Su, Susan M Pullen, William R Wilson

Mol Cancer Ther· November 2014

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A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.
Stephen M F Jamieson, Yongchuan Gu, Donya Moradi Manesh, Jad El-Hoss, Duohui Jing, Susan M Pullen

Biochem Pharmacol· March 2014

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DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.
Rachelle S Singleton, Christopher P Guise, Dianne M Ferry, Susan M Pullen, Mary J Dorie

Cancer Res· May 2009

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Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.
Adam V Patterson, Dianne M Ferry, Shelley J Edmunds, Yongchuan Gu, Rachelle S Singleton, Susan M Pullen

Clin Cancer Res· July 2007

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Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.
William R Wilson, Kevin O Hicks, Susan M Pullen, Dianne M Ferry, Nuala A Helsby

Radiat Res· June 2007

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Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
Graham J Atwell, Shangjin Yang, Frederik B Pruijn, Susan M Pullen, Alison Hogg

J Med Chem· March 2007

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Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.
Nuala A Helsby, Graham J Atwell, Shangjin Yang, Brian D Palmer, Robert F Anderson, Susan M Pullen

J Med Chem· June 2004

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In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors.
William R Wilson, Susan M Pullen, Alison Hogg, Stephen M Hobbs, Frederik B Pruijn

Methods Mol Med· March 2004

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Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
Michael P Hay, Graham J Atwell, William R Wilson, Susan M Pullen, William A Denny

J Med Chem· June 2003

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Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.
Moana Tercel, Stephen M Stribbling, Hilary Sheppard, Bronwyn G Siim, Kent Wu, Susan M Pullen

J Med Chem· May 2003

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