Publications by authors named "Fernando Larcher"

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Base edited skin equivalents with clinical potential for ex vivo correction of recessive dystrophic epidermolysis bullosa.
Alex Bassons-Bascuñana, Blanca Duarte, Estela Méndez-Jiménez, Laura Ugalde, Paula Sanabria-Betrián, Fernando Larcher

Mol Ther· November 2025

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Safe and Efficacious Permanent Removal of Large COL7A1 Exons for Gene Reframing as a Reliable Therapeutic Strategy for Recessive Dystrophic Epidermolysis Bullosa.
Sergio López-Manzaneda, Ángeles Mencía, José Bonafont, Alex Bassons-Bascuñana, Marta García, Fernando Larcher

Hum Gene Ther· September 2025

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The Importance of Shared Patient Voices in Advancing Science for Genodermatoses on a Global Scale.
Fauve C A P van Veen, Eli Sprecher, Janice Schwartz, Tom Baker, Edel A O'Toole, Fernando Larcher

J Invest Dermatol· September 2025

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Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion.
Manuel Mataix, Nuria Illera, Inés Hidalgo, Maria Del Carmen de Arriba, Elena Martín, Fernando Larcher

Mol Ther Nucleic Acids· September 2025

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Sephardic origins revealed for rare skin disorder, recessive dystrophic epidermolysis bullosa, in individuals carrying the unique c.6527insC mutation.
Emily Mira Warshauer, Paul A Maier, Goran Runfeldt, Ignacia Fuentes, Maria José Escamez, Fernando Larcher

J Med Genet· September 2025

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Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa.
Irene Jover, Maria C Ramos, María José Escámez, Estrella Lozoya, José R Tormo, Fernando Larcher

Sci Rep· August 2024

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Preclinical model for phenotypic correction of dystrophic epidermolysis bullosa by CRISPR-Cas9 delivery using adenoviral vectors.
Marta García, Jose Bonafont, Jesús Martínez-Palacios, Rudan Xu, Giandomenico Turchiano, Fernando Larcher

Mol Ther Methods Clin Dev· December 2022

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FPR2 DNA Aptamers for Targeted Therapy of Wound Repair.
María Del Carmen de Arriba, Gerónimo Fernández, Esteban Chacón-Solano, Manuel Mataix, Lucía Martínez-Santamaría, Fernando Larcher

J Invest Dermatol· August 2022

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Paired nicking-mediated COL17A1 reframing for junctional epidermolysis bullosa.
Johannes Bischof, Oliver Patrick March, Bernadette Liemberger, Simone Alexandra Haas, Stefan Hainzl, Fernando Larcher

Mol Ther· August 2022

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Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system.
Jonathan O'Keeffe Ahern, Irene Lara-Sáez, Dezhong Zhou, Rodolfo Murillas, Jose Bonafont, Fernando Larcher

Gene Ther· April 2022

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Evaluation of Systemic Gentamicin as Translational Readthrough Therapy for a Patient With Epidermolysis Bullosa Simplex With Muscular Dystrophy Owing to PLEC1 Pathogenic Nonsense Variants.
Lucía Martínez-Santamaría, Rocío Maseda, María Del Carmen de Arriba, Javier A Membrilla, Alberto Iglesias Sigüenza, Fernando Larcher

JAMA Dermatol· April 2022

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Correction of recessive dystrophic epidermolysis bullosa by homology-directed repair-mediated genome editing.
Jose Bonafont, Angeles Mencía, Esteban Chacón-Solano, Wai Srifa, Sriram Vaidyanathan, Fernando Larcher

Mol Ther· June 2021

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Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome.
Victoria Gálvez, Esteban Chacón-Solano, Jose Bonafont, Ángeles Mencía, Wei-Li Di, Fernando Larcher

Mol Ther Methods Clin Dev· September 2020

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Humanization of Tumor Stroma by Tissue Engineering as a Tool to Improve Squamous Cell Carcinoma Xenograft.
Sara Guerrero-Aspizua, Andrea González-Masa, Claudio J Conti, Marta García, Esteban Chacón-Solano, Fernando Larcher

Int J Mol Sci· March 2020

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Early, Non-Invasive Sensing of Sustained Hyperglycemia in Mice Using Millimeter-Wave Spectroscopy.
Aldo Moreno-Oyervides, Pedro Martín-Mateos, M Carmen Aguilera-Morillo, Giacomo Ulisse, María C Arriba, Fernando Larcher

Sensors (Basel)· July 2019

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Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in recessive dystrophic epidermolysis bullosa.
Su M Lwin, Farhatullah Syed, Wei-Li Di, Tendai Kadiyirire, Lu Liu, Fernando Larcher

JCI Insight· June 2019

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Clinically Relevant Correction of Recessive Dystrophic Epidermolysis Bullosa by Dual sgRNA CRISPR/Cas9-Mediated Gene Editing.
Jose Bonafont, Ángeles Mencía, Marta García, Raúl Torres, Sandra Rodríguez, Fernando Larcher

Mol Ther· May 2019

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CRISPR/Cas9-Mediated In Situ Correction of LAMB3 Gene in Keratinocytes Derived from a Junctional Epidermolysis Bullosa Patient.
Daniela Benati, Francesca Miselli, Fabienne Cocchiarella, Clarissa Patrizi, Marta Carretero, Fernando Larcher

Mol Ther· November 2018

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Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells.
Ángeles Mencía, Cristina Chamorro, Jose Bonafont, Blanca Duarte, Almudena Holguin, Fernando Larcher

Mol Ther Nucleic Acids· June 2018

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COL7A1 Editing via CRISPR/Cas9 in Recessive Dystrophic Epidermolysis Bullosa.
Stefan Hainzl, Patricia Peking, Thomas Kocher, Eva M Murauer, Fernando Larcher

Mol Ther· November 2017

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An RNA-targeted therapy for dystrophic epidermolysis bullosa.
Patricia Peking, Ulrich Koller, Blanca Duarte, Rodolfo Murillas, Susanne Wolf, Fernando Larcher

Nucleic Acids Res· September 2017

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Effects of photodynamic therapy on dermal fibroblasts from xeroderma pigmentosum and Gorlin-Goltz syndrome patients.
Alicia Zamarrón, Marta García, Marcela Del Río, Fernando Larcher, Ángeles Juarranz

Oncotarget· September 2017

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Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range.
Fabian Dornuf, Pedro Martín-Mateos, Blanca Duarte, Bernhard Hils, Oscar Elias Bonilla-Manrique, Fernando Larcher

Sci Rep· July 2017

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Correction of Recessive Dystrophic Epidermolysis Bullosa by Transposon-Mediated Integration of COL7A1 in Transplantable Patient-Derived Primary Keratinocytes.
Maria Carmela Latella, Fabienne Cocchiarella, Laura De Rosa, Giandomenico Turchiano, Manuel A F V Gonçalves, Fernando Larcher

J Invest Dermatol· April 2017

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In-vivo, non-invasive detection of hyperglycemic states in animal models using mm-wave spectroscopy.
Pedro Martín-Mateos, Fabian Dornuf, Blanca Duarte, Bernhard Hils, Aldo Moreno-Oyervides, Fernando Larcher

Sci Rep· September 2016

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