Publications by authors named "Rodolfo Murillas"

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Safe and Efficacious Permanent Removal of Large COL7A1 Exons for Gene Reframing as a Reliable Therapeutic Strategy for Recessive Dystrophic Epidermolysis Bullosa.
Sergio López-Manzaneda, Ángeles Mencía, José Bonafont, Alex Bassons-Bascuñana, Marta García, Rodolfo Murillas

Hum Gene Ther· September 2025

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Nonviral CRISPR/Cas9 mutagenesis for streamlined generation of mouse lung cancer models.
Irene Lara-Sáez, Ángeles Mencía, Enrique Recuero, Yinghao Li, Marta García, Rodolfo Murillas

Proc Natl Acad Sci U S A· July 2024

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Preclinical model for phenotypic correction of dystrophic epidermolysis bullosa by CRISPR-Cas9 delivery using adenoviral vectors.
Marta García, Jose Bonafont, Jesús Martínez-Palacios, Rudan Xu, Giandomenico Turchiano, Rodolfo Murillas

Mol Ther Methods Clin Dev· December 2022

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Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system.
Jonathan O'Keeffe Ahern, Irene Lara-Sáez, Dezhong Zhou, Rodolfo Murillas, Jose Bonafont

Gene Ther· April 2022

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Hedgehog Signalling Modulates Immune Response and Protects against Experimental Autoimmune Encephalomyelitis.
Alicia Ballester, Adriana Guijarro, Beatriz Bravo, Javier Hernández, Rodolfo Murillas

Int J Mol Sci· March 2022

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Correction of recessive dystrophic epidermolysis bullosa by homology-directed repair-mediated genome editing.
Jose Bonafont, Angeles Mencía, Esteban Chacón-Solano, Wai Srifa, Sriram Vaidyanathan, Rodolfo Murillas

Mol Ther· June 2021

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Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome.
Victoria Gálvez, Esteban Chacón-Solano, Jose Bonafont, Ángeles Mencía, Wei-Li Di, Rodolfo Murillas

Mol Ther Methods Clin Dev· September 2020

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Clinically Relevant Correction of Recessive Dystrophic Epidermolysis Bullosa by Dual sgRNA CRISPR/Cas9-Mediated Gene Editing.
Jose Bonafont, Ángeles Mencía, Marta García, Raúl Torres, Sandra Rodríguez, Rodolfo Murillas

Mol Ther· May 2019

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Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells.
Ángeles Mencía, Cristina Chamorro, Jose Bonafont, Blanca Duarte, Almudena Holguin, Rodolfo Murillas

Mol Ther Nucleic Acids· June 2018

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An RNA-targeted therapy for dystrophic epidermolysis bullosa.
Patricia Peking, Ulrich Koller, Blanca Duarte, Rodolfo Murillas, Susanne Wolf

Nucleic Acids Res· September 2017

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Identification of two rare and novel large deletions in ITGB4 gene causing epidermolysis bullosa with pyloric atresia.
Ángeles Mencía, Marta García, Eva García, Sara Llames, Alexandra Charlesworth, Rodolfo Murillas

Exp Dermatol· April 2016

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Gene Editing for the Efficient Correction of a Recurrent COL7A1 Mutation in Recessive Dystrophic Epidermolysis Bullosa Keratinocytes.
Cristina Chamorro, Angeles Mencía, David Almarza, Blanca Duarte, Hildegard Büning, Rodolfo Murillas

Mol Ther Nucleic Acids· April 2016

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RNAi-mediated knockdown of IKK1 in transgenic mice using a transgenic construct containing the human H1 promoter.
Rodolfo Moreno-Maldonado, Rodolfo Murillas, Manuel Navarro, Angustias Page, Cristian Suarez-Cabrera

ScientificWorldJournal· December 2014

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Long-term skin regeneration from a gene-targeted human epidermal stem cell clone.
Blanca Duarte, Francesca Miselli, Rodolfo Murillas, Luis Espinosa-Hevia, Juan Cruz Cigudosa

Mol Ther· November 2014

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Targeted gene therapy and cell reprogramming in Fanconi anemia.
Paula Rio, Rocio Baños, Angelo Lombardo, Oscar Quintana-Bustamante, Lara Alvarez, Rodolfo Murillas

EMBO Mol Med· June 2014

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Keratinocyte cell lines derived from severe generalized recessive epidermolysis bullosa patients carrying a highly recurrent COL7A1 homozygous mutation: models to assess cell and gene therapies in vitro and in vivo.
Cristina Chamorro, David Almarza, Blanca Duarte, Sara G Llames, Rodolfo Murillas

Exp Dermatol· September 2013

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Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland.
Elena García-Zaragoza, Raquel Pérez-Tavarez, Alicia Ballester, Vanesa Lafarga, Anaïs Jiménez-Reinoso, Rodolfo Murillas

Dev Biol· December 2012

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Development of a bioengineered skin-humanized mouse model for psoriasis: dissecting epidermal-lymphocyte interacting pathways.
Sara Guerrero-Aspizua, Marta García, Rodolfo Murillas, Luisa Retamosa, Nuria Illera

Am J Pathol· December 2010

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N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies.
Prashant Sharma, Rodolfo Murillas, Huafeng Zhang, Michael R Kuehn

J Cell Sci· April 2010

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Long-term engraftment of single genetically modified human epidermal holoclones enables safety pre-assessment of cutaneous gene therapy.
Fernando Larcher, Elena Dellambra, Laura Rico, Sergio Bondanza, Rodolfo Murillas

Mol Ther· September 2007

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The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.
Andrew Oberst, Martina Malatesta, Rami I Aqeilan, Mario Rossi, Paolo Salomoni, Rodolfo Murillas

Proc Natl Acad Sci U S A· July 2007

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Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways.
Christophe Cataisson, Elizabeth Joseloff, Rodolfo Murillas, Alice Wang, Coralyn Atwell

J Immunol· September 2003

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A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis.
M Llanos Casanova, Fernando Larcher, Benito Casanova, Rodolfo Murillas, M Jesús Fernández-Aceñero

Cancer Res· June 2002

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Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.
Rodolfo Murillas, Kimberly S Simms, Shigetsugu Hatakeyama, Allan M Weissman, Michael R Kuehn

J Biol Chem· January 2002

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