Publications by authors named "Fernando Rock"

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Dual inhibition of αβ and αβ reduces fibrogenesis in lung tissue explants from patients with IPF.
Martin L Decaris, Johanna R Schaub, Chun Chen, Jacob Cha, Gail G Lee, Fernando Rock

Respir Res· October 2021

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Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.
David S Carter, Robert T Jacobs, Yvonne R Freund, Pamela W Berry, Tsutomu Akama, Fernando Rock

ACS Infect Dis· February 2020

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Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
Tsutomu Akama, Yvonne R Freund, Pamela W Berry, David S Carter, Eric E Easom, Fernando Rock

ACS Infect Dis· February 2020

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Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
Robert T Jacobs, Christopher S Lunde, Yvonne R Freund, Vincent Hernandez, Xianfeng Li, Fernando Rock

J Med Chem· March 2019

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Examining the Benefits of the Boron-Based Mechanism of Action and Physicochemical Properties of Tavaborole in the Treatment of Onychomycosis.
Bryan Markinson, Mahmoud Ghannoum, Tate Winter, Anthony Rycerz, Fernando Rock

J Am Podiatr Med Assoc· January 2018

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Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
Xianfeng Li, Vincent Hernandez, Fernando L Rock, Wai Choi, Yvonne S L Mak

J Med Chem· October 2017

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Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.
Thavy Long, Liliana Rojo-Arreola, Da Shi, Nelly El-Sakkary, Kurt Jarnagin, Fernando Rock

PLoS Negl Trop Dis· July 2017

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Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
Andrés Palencia, Xianfeng Li, Wei Bu, Wai Choi, Charles Z Ding, Fernando L Rock

Antimicrob Agents Chemother· October 2016

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Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes.
Chen Dong, Charlotte Virtucio, Olga Zemska, Grober Baltazar, Yasheen Zhou, Fernando Rock

J Pharmacol Exp Ther· September 2016

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Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors.
Tsutomu Akama, Chen Dong, Charlotte Virtucio, David Sullivan, Yasheen Zhou, Fernando Rock

J Pharmacol Exp Ther· December 2013

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Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.
Vincent Hernandez, Thibaut Crépin, Andrés Palencia, Stephen Cusack, Tsutomu Akama, Fernando L Rock

Antimicrob Agents Chemother· March 2013

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Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
Yvonne R Freund, Tsutomu Akama, M R K Alley, Joana Antunes, Chen Dong, Fernando Rock

FEBS Lett· September 2012

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Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.
Yi Xia, Kathy Cao, Yasheen Zhou, M R K Alley, Fernando Rock

Bioorg Med Chem Lett· April 2011

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Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.
Dazhong Ding, Qingqing Meng, Guangwei Gao, Yaxue Zhao, Qing Wang, Fernando Rock

J Med Chem· March 2011

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Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.
Hua Xu, Todd J Sullivan, Jun-ichiro Sekiguchi, Teruo Kirikae, Iwao Ojima, Fernando L Rock

Biochemistry· April 2008

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An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.
Fernando L Rock, Weimin Mao, Anya Yaremchuk, Mikhail Tukalo, Thibaut Crépin

Science· June 2007

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