Publications by authors named "Filip Cuyckens"

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A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation.
Thomas De Vijlder, Dirk Valkenborg, Filip Lemière, Edwin P Romijn, Kris Laukens, Filip Cuyckens

Mass Spectrom Rev· September 2018

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Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework.
Filip Cuyckens, Wenying Li, Adam M Auclair, Kenneth C Cassidy, Cathy Cantalloube

Clin Pharmacol Ther· December 2025

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Advanced quench correction model for quantitative offline radioactivity counting in in vivo drug metabolism studies.
Sam Wouters, Cis Van Looveren, Fetene Tekle, Filip Cuyckens

Drug Metab Dispos· November 2025

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Development of a Robust Platform for Infrared Ion Spectroscopy: A New Addition to the Analytical Toolkit for Enhanced Metabolite Structure Elucidation.
Teun van Wieringen, Arnaud Lubin, Rianne van Outersterp, Jonathan Martens, Eric van Beelen, Filip Cuyckens

Anal Chem· August 2025

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Absorption, distribution, metabolism, and excretion of an antiviral drug-Fc conjugate CD388 following subcutaneous administration of C-CD388 in the rat.
Aline Laenen, Shawn Flanagan, Grayson Hough, Jan Snoeys, Filip Cuyckens

Drug Metab Dispos· July 2025

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Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi.
Megan Ford, Paul J Thomson, Adam Lister, Jan Snoeys, Laurent Leclercq, Filip Cuyckens

Chem Res Toxicol· May 2025

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Investigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry Imaging.
Bryn Flinders, Lennart Huizing, Bhanu Singh, Heng-Keang Lim, Marjolein van Heerden, Filip Cuyckens

J Am Soc Mass Spectrom· February 2025

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CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes.
Laurent Leclercq, Ronald de Vries, Valérie Koppen, Peter Verboven, Filip Cuyckens

Chem Res Toxicol· January 2025

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Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece.
Graeme C Young, Douglas K Spracklin, Alexander D James, Mette G Hvenegaard, Mette L Pedersen, Filip Cuyckens

Clin Pharmacol Ther· May 2024

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Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group.
Wenkui Li, Faye Vazvaei-Smith, Gordon Dear, Jason Boer, Filip Cuyckens

Clin Pharmacol Ther· May 2024

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Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.
Filip Cuyckens, Mette G Hvenegaard, Kenneth C Cassidy, Douglas K Spracklin, Alexander D James

Drug Metab Dispos· February 2024

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Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.
Graeme C Young, Douglas K Spracklin, Alexander D James, Mette G Hvenegaard, Graeme Scarfe, Filip Cuyckens

Clin Pharmacol Ther· April 2023

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Targeted Small-Molecule Identification Using Heartcutting Liquid Chromatography-Infrared Ion Spectroscopy.
Rianne E van Outersterp, Jitse Oosterhout, Christoph R Gebhardt, Giel Berden, Udo F H Engelke, Filip Cuyckens

Anal Chem· February 2023

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Evaluation of table-top lasers for routine infrared ion spectroscopy in the analytical laboratory.
Rianne E van Outersterp, Jonathan Martens, André Peremans, Laurent Lamard, Filip Cuyckens

Analyst· November 2021

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Multimodal biomarker discovery for active Onchocerca volvulus infection.
Ole Lagatie, Emmanuel Njumbe Ediage, Dirk Van Roosbroeck, Stijn Van Asten, Ann Verheyen, Filip Cuyckens

PLoS Negl Trop Dis· November 2021

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Evaluation of micropillar array columns for chromatographic separation of phosphorothioated oligonucleotides and their diastereomers.
Lieve Dillen, Tiny Deschrijver, Kurt Van Mol, Jeff Op de Beeck, Paul Jacobs, Filip Cuyckens

Anal Sci Adv· August 2021

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Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.
Ellen Scheers, Carine Borgmans, Chi Keung, Hilde Bohets, Inneke Wynant, Filip Cuyckens

Xenobiotica· February 2021

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Quantitative Mass Spectrometry Imaging to Study Drug Distribution in the Intestine Following Oral Dosing.
Lennart R S Huizing, James McDuffie, Filip Cuyckens, Marjolein van Heerden, Tatiana Koudriakova

Anal Chem· February 2021

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Toward simplified oral lipid-based drug delivery using mono-/di-glycerides as single component excipients.
Alexandra-Roxana Ilie, Brendan T Griffin, Maria Vertzoni, Martin Kuentz, Filip Cuyckens

Drug Dev Ind Pharm· December 2020

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Mass spectrometry-based identification of -, - and -isomers using infrared ion spectroscopy.
Rianne E van Outersterp, Jonathan Martens, Giel Berden, Valerie Koppen, Filip Cuyckens

Analyst· September 2020

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2-Methyl-pentanoyl-carnitine (2-MPC): a urine biomarker for patent Ascaris lumbricoides infection.
Ole Lagatie, Ann Verheyen, Stijn Van Asten, Maurice R Odiere, Yenny Djuardi, Filip Cuyckens

Sci Rep· September 2020

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Infrared ion spectroscopy: New opportunities for small-molecule identification in mass spectrometry - A tutorial perspective.
Jonathan Martens, Rianne E van Outersterp, Rob J Vreeken, Filip Cuyckens, Karlien L M Coene

Anal Chim Acta· January 2020

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Selective drug metabolite trace analysis by very high-volume injections and heartcut two-dimensional (2D)-ultrahigh performance liquid chromatography (UHPLC).
Valerie Koppen, Cis Van Looveren, Isabelle François, Filip Cuyckens

J Chromatogr A· September 2019

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Adduct ion formation as a tool for the molecular structure assessment of ten isomers in traveling wave and trapped ion mobility spectrometry.
Darya Hadavi, Erik de Lange, Jan Jordens, Ynze Mengerink, Filip Cuyckens

Rapid Commun Mass Spectrom· July 2019

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Ion mobility mass spectrometry: Small molecule applications.
Filip Cuyckens

Rapid Commun Mass Spectrom· July 2019

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Strategies and analytical workflows to extend the dynamic range in quantitative LC-MS/MS analysis.
Emmanuel Njumbe Ediage, Tania Aerts, Arnaud Lubin, Filip Cuyckens, Lieve Dillen

Bioanalysis· June 2019

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