Publications by authors named "Jason Boer"

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Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework.
Filip Cuyckens, Wenying Li, Adam M Auclair, Kenneth C Cassidy, Cathy Cantalloube, Jason Boer

Clin Pharmacol Ther· December 2025

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2023 White Paper on Recent Issues in Bioanalysis: Deuterated Drugs; LNP; Tumor/FFPE Biopsy; Targeted Proteomics; Small Molecule Covalent Inhibitors; Chiral Bioanalysis; Remote Regulatory Assessments; Sample Reconciliation/Chain of Custody - Recommendations on Mass Spectrometry, Chromatography, Sample Preparation Latest Developments, Challenges, and Solutions and BMV/Regulated Bioanalysis - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/IVD/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Mike Baratta, Wenying Jian, Shawna Hengel, Surinder Kaur, Jennifer Cunliffe, Jason Boer

Bioanalysis· June 2024

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Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group.
Wenkui Li, Faye Vazvaei-Smith, Gordon Dear, Jason Boer, Filip Cuyckens

Clin Pharmacol Ther· May 2024

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2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome ( - Recommendations on Industry/Regulators Consensus on BMV of Biotherapeutics by LCMS, Advanced Application in Hybrid Assays, Regulatory Challenges in Mass Spec, Innovation in Small Molecules, Peptides and Oligos).
Hendrik Neubert, Stephen C Alley, Anita Lee, Wenying Jian, Michael Buonarati, Jason Boer

Bioanalysis· February 2021

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Biotransformation: Impact and Application of Metabolism in Drug Discovery.
Julia Shanu-Wilson, Liam Evans, Stephen Wrigley, Jonathan Steele, James Atherton, Jason Boer

ACS Med Chem Lett· November 2020

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.
Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Jason Boer

PLoS One· December 2018

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In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions.
Qiang Zhang, Yan Zhang, Jason Boer, Jack G Shi, Peidi Hu

Drug Metab Dispos· June 2017

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Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans.
Jason Boer, Ruth Young-Sciame, Fiona Lee, Kevin J Bowman, Xiaoqing Yang

Drug Metab Dispos· October 2016

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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Qiang Zhang, Yan Zhang, Sharon Diamond, Jason Boer, Jennifer J Harris

Drug Metab Dispos· October 2014

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A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.
Xiangdong Liu, Qian Wang, Gengjie Yang, Cindy Marando, Holly K Koblish, Jason Boer

Clin Cancer Res· November 2011

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Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications.
Sharon Diamond, Jason Boer, Thomas P Maduskuie, Nikoo Falahatpisheh, Yu Li

Drug Metab Dispos· August 2010

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Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Daniel P Walker, Michael P Zawistoski, Molly A McGlynn, Jian-Cheng Li, Daniel W Kung, Jason Boer

Bioorg Med Chem Lett· June 2009

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The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism.
Michael B Fisher, Kirk R Henne, Jason Boer

Curr Opin Drug Discov Devel· January 2006

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A comprehensive listing of bioactivation pathways of organic functional groups.
Amit S Kalgutkar, Iain Gardner, R Scott Obach, Christopher L Shaffer, Ernesto Callegari, Jason Boer

Curr Drug Metab· June 2005

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