Publications by authors named "Sharon Diamond"

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Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor.
Minh H Nguyen, Anlai Wang, Lisa Truong, Ke Zhang, Hai-Fen Ye, Sharon Diamond

ACS Med Chem Lett· June 2025

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Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor.
Qinda Ye, Artem Shvartsbart, Zhenwu Li, Pei Gan, Rocco L Policarpo, Sharon Diamond

J Med Chem· January 2025

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Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
Joshua R Hummel, Kai-Jiong Xiao, Jeffrey C Yang, Leslie B Epling, Ken Mukai, Sharon Diamond

J Med Chem· February 2024

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Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
Minh H Nguyen, Hai-Fen Ye, Yao Xu, Lisa Truong, April Horsey, Sharon Diamond

ACS Med Chem Lett· March 2023

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Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors.
Qinda Ye, Kai Liu, Hai-Fen Ye, Jun Pan, Alexander Sokolsky, Sharon Diamond

ACS Med Chem Lett· January 2023

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Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Alexander Sokolsky, Oleg Vechorkin, Joshua R Hummel, Evan D Styduhar, Anlai Wang, Sharon Diamond

ACS Med Chem Lett· January 2023

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Discovery of 5,7-Dihydro-6-pyrrolo[2,3-]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors.
Alexander Sokolsky, Sarah Winterton, Keith Kennedy, Katherine Drake, Kristine Stump, Sharon Diamond

ACS Med Chem Lett· November 2022

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Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11β-HSD1.
David M Burns, Chunhong He, Yun-Long Li, Jincong Zhuo, Ding-Quan Qian, Sharon Diamond

Bioorg Med Chem Lett· October 2022

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Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.
Colin Zhang, Meizhong Xu, Chunhong He, Jincong Zhuo, David M Burns, Sharon Diamond

Bioorg Med Chem Lett· August 2022

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Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2.
Minh H Nguyen, Onur Atasoylu, Liangxing Wu, Kanishk Kapilashrami, Michelle Pusey, Sharon Diamond

ACS Med Chem Lett· July 2022

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Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Holly K Koblish, Liangxing Wu, Liang-Chuan S Wang, Phillip C C Liu, Richard Wynn, Sharon Diamond

Cancer Discov· June 2022

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Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Liangxing Wu, Colin Zhang, Chunhong He, Dingquan Qian, Liang Lu, Sharon Diamond

J Med Chem· August 2021

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Plasma pharmacokinetics and distribution of ruxolitinib into skin following oral and topical administration in minipigs.
Indushekhar Persaud, Sharon Diamond, Rina Pan, Krista Burke, Jennifer Harris

Int J Pharm· November 2020

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Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Maryanne Covington, Xin He, Monika Scuron, Jun Li, Robert Collins, Sharon Diamond

Eur J Pharmacol· October 2020

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INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models.
Phillip C C Liu, Holly Koblish, Liangxing Wu, Kevin Bowman, Sharon Diamond

PLoS One· July 2020

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Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
Niu Shin, Matthew Stubbs, Holly Koblish, Eddy W Yue, Maxim Soloviev, Sharon Diamond

J Pharmacol Exp Ther· July 2020

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INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ).
Eddy W Yue, Yun-Long Li, Brent Douty, Chunhong He, Song Mei, Sharon Diamond

ACS Med Chem Lett· November 2019

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Effects of Epacadostat on Brain Extracellular Fluid Concentrations of Serotonin-an Intracerebral Microdialysis Study in Sprague-Dawley Rats.
Yan Zhang, Kevin Bowman, Janet Maleski, Sharon Diamond, Swamy Yeleswaram

Drug Metab Dispos· July 2019

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The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.
Matthew C Stubbs, Timothy C Burn, Richard Sparks, Thomas Maduskuie, Sharon Diamond

Clin Cancer Res· January 2019

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.
Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Sharon Diamond

PLoS One· December 2018

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INCB040093 Is a Novel PI3K Inhibitor for the Treatment of B Cell Lymphoid Malignancies.
Niu Shin, Yun-Long Li, Song Mei, Kathy He Wang, Leslie Hall, Sharon Diamond

J Pharmacol Exp Ther· January 2018

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In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions.
Qiang Zhang, Yan Zhang, Jason Boer, Jack G Shi, Peidi Hu, Sharon Diamond

Drug Metab Dispos· June 2017

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Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans.
Jason Boer, Ruth Young-Sciame, Fiona Lee, Kevin J Bowman, Xiaoqing Yang, Sharon Diamond

Drug Metab Dispos· October 2016

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Impact on creatinine renal clearance by the interplay of multiple renal transporters: a case study with INCB039110.
Yan Zhang, Mark S Warren, Xuexiang Zhang, Sharon Diamond, Bill Williams

Drug Metab Dispos· April 2015

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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Qiang Zhang, Yan Zhang, Sharon Diamond, Jason Boer, Jennifer J Harris

Drug Metab Dispos· October 2014

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