Publications by authors named "Frances Ashcroft"

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Residue 39 of Kir6.2 drives a difference in ATP sensitivity in human and canine beta-cell K channels.
Natascia Vedovato, Frances M Ashcroft, Brian Catchpole, Lucy J Davison

Front Physiol· November 2025

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KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts.
Marie-Elisabeth Burkart, Josephine Kurzke, Robert Jacobi, Jorge Vera, Frances M Ashcroft

Brain· December 2024

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Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.
Thomas G Hill, Rui Gao, Anna Benrick, Lakshmi Kothegala, Nils Rorsman, Frances M Ashcroft

Nat Metab· November 2024

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A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life.
Natascia Vedovato, Maria V Salguero, Siri Atma W Greeley, Christine H Yu, Louis H Philipson, Frances M Ashcroft

Diabetologia· May 2024

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KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture.
Frances M Ashcroft

Diabetes· June 2023

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Glucokinase activity in diabetes: too much of a good thing?
Frances M Ashcroft, Matthew Lloyd, Elizabeth A Haythorne

Trends Endocrinol Metab· February 2023

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Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
Elizabeth Haythorne, Matthew Lloyd, John Walsby-Tickle, Andrei I Tarasov, Jonas Sandbrink, Frances M Ashcroft

Nat Commun· November 2022

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The dynamic interplay of PIP and ATP in the regulation of the K channel.
Tanadet Pipatpolkai, Samuel G Usher, Natascia Vedovato, Frances M Ashcroft, Phillip J Stansfeld

J Physiol· October 2022

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Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate.
John N Koberstein, Melissa L Stewart, Chadwick B Smith, Andrei I Tarasov, Frances M Ashcroft

Proc Natl Acad Sci U S A· August 2022

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Dissection-independent production of sporozoites from whole mosquitoes.
Joshua Blight, Katarzyna A Sala, Erwan Atcheson, Holger Kramer, Aadil El-Turabi, Frances M Ashcroft

Life Sci Alliance· July 2021

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The Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion.
Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Frances M Ashcroft

Diabetes· May 2021

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Voices: Insulin and beyond.
Jesse Roth, Frances M Ashcroft, Claes B Wollheim, Timothy J Kieffer, Alan D Cherrington

Cell Metab· April 2021

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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time.
Samuel G Usher, Frances M Ashcroft, Michael C Puljung

J Vis Exp· March 2021

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Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice.
Gregor Sachse, Elizabeth Haythorne, Peter Proks, Michelle Stewart, Heather Cater, Frances M Ashcroft

Wellcome Open Res· March 2021

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Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease.
Tanadet Pipatpolkai, Robin A Corey, Peter Proks, Frances M Ashcroft, Phillip J Stansfeld

Commun Chem· October 2020

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New insights into K channel gene mutations and neonatal diabetes mellitus.
Tanadet Pipatpolkai, Samuel Usher, Phillip J Stansfeld, Frances M Ashcroft

Nat Rev Endocrinol· July 2020

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Low extracellular magnesium does not impair glucose-stimulated insulin secretion.
Lisanne M M Gommers, Thomas G Hill, Frances M Ashcroft, Jeroen H F de Baaij

PLoS One· February 2020

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Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.
Samuel G Usher, Frances M Ashcroft, Michael C Puljung

Elife· January 2020

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Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.
Nikita Ved, Angela Curran, Frances Mary Ashcroft, Duncan Burnaby Sparrow

Lab Anim· December 2019

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Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With -Related Neonatal Diabetes. Diabetes Care 2014;37:3333-3335.
Nele Myngheer, Karel Allegaert, Andrew Hattersley, Tim McDonald, Holger Kramer, Frances M Ashcroft

Diabetes Care· July 2019

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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F Brereton, Andrei I Tarasov, Frances M Ashcroft

Nat Commun· June 2019

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Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
James Cantley, Frances M Ashcroft

BMC Biol· April 2019

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Correction: Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.
Carolina Lahmann, Holger B Kramer, Frances M Ashcroft

PLoS One· April 2019

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Activation mechanism of ATP-sensitive K channels explored with real-time nucleotide binding.
Michael Puljung, Natascia Vedovato, Samuel Usher, Frances Ashcroft

Elife· February 2019

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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Elisa Vergari, Jakob G Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Frances M Ashcroft

Nat Commun· January 2019

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