Publications by authors named "Frances Humby"

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Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8 T Cell Clones.
Lucy E Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H Gray

Arthritis Rheumatol· June 2025

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Dynamic Bayesian network models for self-management of chronic diseases: Rheumatoid arthritis case-study.
Ali Fahmi, Amy MacBrayne, Frances Humby, Paul Curzon, William Marsh

Comput Biol Med· May 2025

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Substantive Similarities Between Synovial Fluid and Synovial Tissue T cells in Inflammatory Arthritis Via Single-Cell RNA and T Cell Receptor Sequencing.
Lucy E Durham, Frances C Humby, Nora Ng, Sarah Ryan, Rosamond Nuamah

Arthritis Rheumatol· November 2024

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Editorial: Synovial pathobiology and pathogenesis of inflammatory arthritis, volume II.
Annabelle Small, Frances Humby, Mihir D Wechalekar

Front Med (Lausanne)· July 2024

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BiTE therapy for rheumatoid arthritis.
Frances Humby, Bruce Kirkham, Leonie Taams

Nat Med· June 2024

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Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.
Alessandra Nerviani, Marie-Astrid Boutet, Giulia Maria Ghirardi, Katriona Goldmann, Elisabetta Sciacca, Frances Humby

Nat Commun· March 2024

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Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials.
Felice Rivellese, Alessandra Nerviani, Giovanni Giorli, Louise Warren, Edyta Jaworska, Frances Humby

Lancet Rheumatol· November 2023

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Attitudes towards technology supported rheumatoid arthritis care: investigating patient- and clinician-perceived opportunities and barriers.
Amy MacBrayne, Paul Curzon, Hamit Soyel, William Marsh, Norman Fenton, Frances Humby

Rheumatol Adv Pract· October 2023

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Editorial: Synovial pathobiology and pathogenesis of inflammatory arthritis.
Annabelle Small, Frances Humby, Mihir D Wechalekar

Front Med (Lausanne)· August 2022

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Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial.
Felice Rivellese, Anna E A Surace, Katriona Goldmann, Elisabetta Sciacca, Cankut Çubuk, Frances Humby

Nat Med· June 2022

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Editorial: Synovial Tissue: Turning the Page to Precision Medicine in Arthritis?
Carl Kieran Orr, Frances Humby, João Eurico Fonseca

Front Med (Lausanne)· November 2021

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A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients.
Alessandra Nerviani, Maria Di Cicco, Arti Mahto, Gloria Lliso-Ribera, Felice Rivellese, Frances Humby

Front Immunol· March 2021

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Fibrocytes in early and long-standing rheumatoid arthritis: a 6-month trial with repeated synovial biopsy, imaging and lung function test.
Søren Andreas Just, Christian Nielsen, Jens Christian Werlinrud, Pia Veldt Larsen, Eva Kildall Hejbøl, Frances Humby

RMD Open· March 2021

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Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial.
Frances Humby, Patrick Durez, Maya H Buch, Myles J Lewis, Hasan Rizvi

Lancet· January 2021

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Response to: 'Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients' by Buch .
Frances Humby, Myles Lewis, Michael J Townsend, Costantino Pitzalis

Ann Rheum Dis· November 2020

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From Personalised Predictions to Targeted Advice: Improving Self-Management in Rheumatoid Arthritis.
Ali Fahmi, Hamit Soyel, William Marsh, Paul Curzon, Amy MacBrayne, Frances Humby

Stud Health Technol Inform· November 2020

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Efficacy, Safety, and Sample Quality of Ultrasound-Guided Synovial Needle Biopsy in Clinical Practice and Research: A Prospective Observational Study.
Vasco C Romão, Joaquim Polido-Pereira, Rita Barros, Rita Luís, Bruno Vidal, Frances Humby

Arthritis Care Res (Hoboken)· October 2020

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Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study.
Vasco C Romão, Frances Humby, Stephen Kelly, Maria Di Cicco, Arti Mahto

Semin Arthritis Rheum· August 2020

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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.
Mattias N D Svensson, Martina Zoccheddu, Shen Yang, Gyrid Nygaard, Christian Secchi, Frances Humby

Sci Adv· June 2020

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Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC).
Gloria Lliso-Ribera, Frances Humby, Myles Lewis, Alessandra Nerviani, Daniele Mauro

Ann Rheum Dis· December 2019

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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4 T Cell Metabolic Rewiring.
Valentina Pucino, Michelangelo Certo, Vinay Bulusu, Danilo Cucchi, Katriona Goldmann, Frances Humby

Cell Metab· December 2019

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Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis.
Javier Rodríguez-Ubreva, Carlos de la Calle-Fabregat, Tianlu Li, Laura Ciudad, Maria L Ballestar, Frances Humby

Ann Rheum Dis· November 2019

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Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes.
Myles J Lewis, Michael R Barnes, Kevin Blighe, Katriona Goldmann, Sharmila Rana, Frances Humby

Cell Rep· August 2019

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Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients.
Frances Humby, Myles Lewis, Nandhini Ramamoorthi, Jason A Hackney, Michael R Barnes

Ann Rheum Dis· June 2019

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