Publications by authors named "Francesca Seghetti"

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Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease.
Rebecca Orioli, Giuliana Sarno, Francesca Seghetti, Silvia Gobbi, Federica Belluti

Eur J Med Chem· October 2025

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Alkyl Tail Variation on Chalcone-Based Quaternary Pyridinium Salts as Rule-of-Thumb for Antimicrobial Activity.
Francesca Seghetti, Riccardo Ocello, Alessandra Bisi, Matteo Masetti, Silvia Gobbi

Arch Pharm (Weinheim)· May 2025

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Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis.
Cécile Exertier, Alessandra Salerno, Lorenzo Antonelli, Annarita Fiorillo, Riccardo Ocello, Francesca Seghetti

J Med Chem· January 2024

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Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold.
Ersilia De Lorenzi, Francesca Seghetti, Andrea Tarozzi, Letizia Pruccoli, Cecilia Contardi

Eur J Med Chem· April 2023

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Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds.
Francesca Seghetti, Federica Belluti, Angela Rampa, Silvia Gobbi, Jenny Legac

Future Med Chem· December 2022

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Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology.
Francesca Seghetti, Silvia Gobbi, Federica Belluti, Angela Rampa, Alessandra Bisi

Curr Med Chem· August 2022

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Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One.
Alessandra Salerno, Francesca Seghetti, Jessica Caciolla, Elisa Uliassi, Eleonora Testi

J Med Chem· July 2022

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Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design.
Annarita Fiorillo, Gianni Colotti, Cécile Exertier, Anastasia Liuzzi, Francesca Seghetti

Front Mol Biosci· July 2022

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Modulation of Amyloid β-Induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues.
Ersilia De Lorenzi, Davide Franceschini, Cecilia Contardi, Rita Maria Concetta Di Martino, Francesca Seghetti

Int J Mol Sci· April 2022

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Extended Multicomponent Reactions with Indole Aldehydes: Access to Unprecedented Polyheterocyclic Scaffolds, Ligands of the Aryl Hydrocarbon Receptor.
Ouldouz Ghashghaei, Marina Pedrola, Francesca Seghetti, Victor V Martin, Ricardo Zavarce

Angew Chem Int Ed Engl· February 2021

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Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease.
Rita Maria Concetta Di Martino, Letizia Pruccoli, Alessandra Bisi, Silvia Gobbi, Angela Rampa, Francesca Seghetti

ACS Chem Neurosci· September 2020

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Curcumin-1,2,3-Triazole Conjugation for Targeting the Cancer Apoptosis Machinery.
Francesca Seghetti, Rita Maria Concetta Di Martino, Elena Catanzaro, Alessandra Bisi, Silvia Gobbi

Molecules· July 2020

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Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation.
Rita Maria Concetta Di Martino, Giovanni Bottegoni, Francesca Seghetti, Debora Russo, Ilaria Penna

ChemMedChem· June 2020

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Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent.
Elena Catanzaro, Francesca Seghetti, Cinzia Calcabrini, Angela Rampa, Silvia Gobbi

Bioorg Chem· May 2019

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Prenylated Curcumin Analogues as Multipotent Tools To Tackle Alzheimer's Disease.
Federica Bisceglia, Francesca Seghetti, Massimo Serra, Morena Zusso, Silvia Gervasoni

ACS Chem Neurosci· March 2019

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Selectivity in multiple multicomponent reactions: types and synthetic applications.
Ouldouz Ghashghaei, Francesca Seghetti, Rodolfo Lavilla

Beilstein J Org Chem· February 2019

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The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones.
Matheus de Freitas Silva, Letizia Pruccoli, Fabiana Morroni, Giulia Sita, Francesca Seghetti

Molecules· July 2018

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