Publications by authors named "Frank Longo"

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Alzheimer's Imaging Consortium.
Andy Liu, Danielle Simmons, Frank Longo, Michael Zeineh, Marios Georgiadis

Alzheimers Dement· December 2025

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Mapping cross-domain drivers of Alzheimer's disease risk through integrated network analysis.
Gregory A Cary, Stephen Keegan, Jesse C Wiley, Jake Gockley, Frank M Longo

bioRxiv· October 2025

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p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia.
Bidisha Chattopadhyaya, Karen K Y Lee, Maria Isabel Carreño-Muñoz, Andrea Paris-Rubianes, Marisol Lavertu-Jolin, Frank M Longo

Brain· August 2025

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Twenty years of therapeutic development in tauopathy mouse models: a scoping review.
Vanessa F Langness, Danielle A Simmons, Tyne L M McHugh, Robert R Butler, James Zhou, Frank M Longo

Alzheimers Dement· August 2025

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Uncovering Heterogeneous Effects via Localized Feature Selection.
Xiaoxia Liu, Jiaqi Gu, Zhaomeng Chen, Benjamin Chu, Linxi Liu, Frank M Longo

bioRxiv· June 2025

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Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
Edward N Wilson, Jacob Umans, Michelle S Swarovski, Paras S Minhas, Justin H Mendiola, Frank M Longo

NPJ Parkinsons Dis· April 2025

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Small molecule modulation of p75 engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease.
Danielle A Simmons, Namitha Alexander, Gloria Cao, Ido Rippin, Yarine Lugassy, Frank M Longo

Neurotherapeutics· March 2025

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Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington's disease phenotypes.
Danielle A Simmons, Sridhar Selvaraj, Tingshuo Chen, Gloria Cao, Talita Souto Camelo, Frank M Longo

Mol Ther Methods Clin Dev· March 2025

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Plasma Aβ/Aβ is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum.
Alexandra N Trelle, Christina B Young, Hillary Vossler, Javier Ramos Benitez, Karly A Cody, Frank M Longo

Alzheimers Dement· February 2025

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A Small-Molecule TrkB/TrkC Ligand Promotes Neurogenesis and Behavioral Recovery Following Traumatic Brain Injury.
Jian Shi, Tao Yang, Yibing Li, Lily Zhong, Frank M Longo

Neurotrauma Rep· February 2025

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ProBDNF as a Myokine in Skeletal Muscle Injury: Role in Inflammation and Potential for Therapeutic Modulation of p75.
Katherine Aby, Ryan Antony, Tao Yang, Frank M Longo, Yifan Li

Int J Mol Sci· January 2025

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Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
Edward Wilson, Jacob Umans, Michelle Swarovski, Paras Minhas, Øivind Midttun, Frank Longo

Res Sq· September 2024

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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Frank M Longo

Science· August 2024

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A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
Amira Latif-Hernandez, Tao Yang, Robert R Butler, Patricia Moran Losada, Paras S Minhas, Frank M Longo

Alzheimers Dement· July 2024

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p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial.
Hayley R C Shanks, Kewei Chen, Eric M Reiman, Kaj Blennow, Jeffrey L Cummings, Frank M Longo

Nat Med· June 2024

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A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.
Destynie Medeiros, Karen Ayala-Baylon, Hailey Egido-Betancourt, Eric Miller, Christopher Chapleau, Frank M Longo

Dis Model Mech· June 2024

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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Frank M Longo

bioRxiv· June 2024

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Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains.
Gregory A Cary, Jesse C Wiley, Jake Gockley, Stephen Keegan, Sai Sruthi Amirtha Ganesh, Frank M Longo

Alzheimers Dement (N Y)· April 2024

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Organ aging signatures in the plasma proteome track health and disease.
Hamilton Se-Hwee Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Frank M Longo

Nature· December 2023

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A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.
Destynie Medeiros, Karen Ayala-Baylon, Hailey Egido-Betancourt, Eric Miller, Christopher A Chapleau, Frank Longo

bioRxiv· November 2023

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Senolytic therapy for Alzheimer's disease.
Frank M Longo, Stephen M Massa

Nat Med· October 2023

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A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
Amira Latif-Hernandez, Tao Yang, Robert Raymond-Butler, Patricia Moran Losada, Paras Minhas, Frank M Longo

bioRxiv· September 2023

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Open drug discovery in Alzheimer's disease.
Alison D Axtman, Paul E Brennan, Tristan Frappier-Brinton, Ranjita Betarbet, Gregory W Carter, Frank M Longo

Alzheimers Dement (N Y)· May 2023

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Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.
Chinyere Agbaegbu Iweka, Erica Seigneur, Amira Latif Hernandez, Sur Herrera Paredes, Mica Cabrera, Frank M Longo

J Neuroinflammation· February 2023

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Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease.
Danielle A Simmons, Nadia P Belichenko, Frank M Longo

J Huntingtons Dis· January 2023

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