Publications by authors named "Fred Ledley"

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Contribution of revenue from drugs subject to price negotiation under the Inflation Reduction Act to the revenue, profit, and returns of pharmaceutical manufacturers.
Joseph Twomey, Leonhard Kersten, Edward W Zhou, Fred D Ledley

Drug Discov Today· December 2025

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Sustaining pharmaceutical innovation after the Inflation Reduction Act: trends in R&D spending, equity investment, and business development.
Henry Dao, Fred D Ledley

Drug Discov Today· July 2025

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Modeling impact of inflation reduction act price negotiations on new drug pipeline considering differential contributions of large and small biopharmaceutical companies.
Gregory Vaughan, Roger Du, Fred D Ledley

Clin Trials· February 2025

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Association between expedited review designations and the US or global burden of disease for drugs approved by the US Food and Drug Administration, 2010-2019: a cross-sectional analysis.
Matthew J Jackson, Gregory Vaughan, Fred D Ledley

BMJ Open· March 2024

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Spending on Phased Clinical Development of Approved Drugs by the US National Institutes of Health Compared With Industry.
Edward W Zhou, Matthew J Jackson, Fred D Ledley

JAMA Health Forum· July 2023

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NIH funding for patents that contribute to market exclusivity of drugs approved 2010-2019 and the public interest protections of Bayh-Dole.
Fred D Ledley, Ekaterina Galkina Cleary

PLoS One· July 2023

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Comparing the economic terms of biotechnology licenses from academic institutions with those between commercial firms.
Prateet Shah, Gregory Vaughan, Fred D Ledley

PLoS One· April 2023

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Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010-2019.
Ekaterina Galkina Cleary, Matthew J Jackson, Edward W Zhou, Fred D Ledley

JAMA Health Forum· April 2023

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Comparing long-term value creation after biotech and non-biotech IPOs, 1997-2016.
Ekaterina Galkina Cleary, Laura M McNamee, Skyler de Boer, Jeremy Holden, Liam Fitzgerald, Fred D Ledley

PLoS One· April 2021

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NIH funding for vaccine readiness before the COVID-19 pandemic.
Anthony E Kiszewski, Ekaterina Galkina Cleary, Matthew J Jackson, Fred D Ledley

Vaccine· April 2021

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Late-stage Product Development and Approvals by Biotechnology Companies After Initial Public Offering, 1997-2016.
Laura M McNamee, Ekaterina Galkina Cleary, Sunyi Zhang, Usama Salim, Fred D Ledley

Clin Ther· January 2021

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NIH funding for research underlying new cancer therapies.
Ekaterina Galkina Cleary, Fred D Ledley

Lancet Oncol· June 2020

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We Don't Have to Lose STEM Students to Business.
Naomi L B Wernick, Fred D Ledley

J Microbiol Biol Educ· April 2020

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Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies.
Fred D Ledley, Sarah Shonka McCoy, Gregory Vaughan, Ekaterina Galkina Cleary

JAMA· March 2020

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Representation of Industry in Introductory Biology Textbooks: A Missed Opportunity to Advance STEM Learning.
Sharotka M Simon, Helen Meldrum, Eric Ndung'u, Fred D Ledley

CBE Life Sci Educ· December 2018

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Methods Used to Assess Pharmaceutical Research and Development Costs.
Fred D Ledley

JAMA Intern Med· April 2018

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Contribution of NIH funding to new drug approvals 2010-2016.
Ekaterina Galkina Cleary, Jennifer M Beierlein, Navleen Surjit Khanuja, Laura M McNamee, Fred D Ledley

Proc Natl Acad Sci U S A· March 2018

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As Technologies for Nucleotide Therapeutics Mature, Products Emerge.
Jennifer M Beierlein, Laura M McNamee, Fred D Ledley

Mol Ther Nucleic Acids· December 2017

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Timelines of translational science: From technology initiation to FDA approval.
Laura M McNamee, Michael Jay Walsh, Fred D Ledley

PLoS One· September 2017

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Modeling timelines for translational science in cancer; the impact of technological maturation.
Laura M McNamee, Fred D Ledley

PLoS One· August 2017

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Landscape of Innovation for Cardiovascular Pharmaceuticals: From Basic Science to New Molecular Entities.
Jennifer M Beierlein, Laura M McNamee, Michael J Walsh, Kenneth I Kaitin, Joseph A DiMasi, Fred D Ledley

Clin Ther· July 2017

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Patterns of Innovation in Alzheimer's Disease Drug Development: A Strategic Assessment Based on Technological Maturity.
Jennifer M Beierlein, Laura M McNamee, Michael J Walsh, Fred D Ledley

Clin Ther· August 2015

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What does the current biotech stock market value?
Laura McNamee, Fred Ledley

Nat Biotechnol· August 2015

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Positioning genomics in biology education: content mapping of undergraduate biology textbooks.
Naomi L B Wernick, Eric Ndung'u, Dominique Haughton, Fred D Ledley

J Microbiol Biol Educ· December 2014

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