Publications by authors named "Fred van Leeuwen"

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Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition.
Rachele Niccolai, Camiel Göbel, Klevis Ndoj, Maaike Kreft, Hendrik J Kuiken, Fred van Leeuwen

Neoplasia· December 2025

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Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells.
Muddassir Malik, Willem-Jan de Leeuw, Muhammad Assad Aslam, Eliza Mari Kwesi-Maliepaard, Teun van den Brand, Fred van Leeuwen

Sci Adv· December 2025

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Should I stay or should I go: TFIIIC as assembly factor and barrier in RNA polymerase III transcription.
Wolfram Seifert-Davila, Maria Elize van Breugel, Fred van Leeuwen, Christoph W Müller

Biochem Soc Trans· August 2025

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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma.
Camiel Göbel, Rachele Niccolai, Marnix H P de Groot, Jayashree Jayachandran, Joleen Traets, Fred van Leeuwen

Blood· April 2025

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The choreography of chromatin in RNA polymerase III regulation.
Maria Elize van Breugel, Alan Gerber, Fred van Leeuwen

Biochem Soc Trans· June 2024

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Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly.
Maria Elize van Breugel, Ila van Kruijsbergen, Chitvan Mittal, Cor Lieftink, Ineke Brouwer, Fred van Leeuwen

Mol Cell· December 2023

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Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model.
Inbal Maniv, Mahasen Sarji, Anwar Bdarneh, Alona Feldman, Roi Ankawa, Fred W van Leeuwen

Nat Commun· September 2023

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DOT1L regulates chromatin reorganization and gene expression during sperm differentiation.
Mélina Blanco, Laila El Khattabi, Clara Gobé, Marion Crespo, Manon Coulée, Fred Van Leeuwen

EMBO Rep· June 2023

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Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting.
Ineke Brouwer, Emma Kerklingh, Fred van Leeuwen, Tineke L Lenstra

Nat Struct Mol Biol· May 2023

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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Lisa Willemsen, Koen H M Prange, Annette E Neele, Cindy P A A van Roomen, Marion Gijbels, Fred van Leeuwen

Cell Rep· November 2022

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DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors .
Eliza Mari Kwesi-Maliepaard, Muddassir Malik, Tibor van Welsem, Remco van Doorn, Maarten H Vermeer, Fred van Leeuwen

Front Genet· November 2022

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The histone methyltransferase SETD2 negatively regulates cell size.
Thom M Molenaar, Muddassir Malik, Joana Silva, Ning Qing Liu, Judith H I Haarhuis, Fred van Leeuwen

J Cell Sci· October 2022

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SETD2: from chromatin modifier to multipronged regulator of the genome and beyond.
Thom M Molenaar, Fred van Leeuwen

Cell Mol Life Sci· June 2022

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Epi-Decoder: Decoding the Local Proteome of a Genomic Locus by Massive Parallel Chromatin Immunoprecipitation Combined with DNA-Barcode Sequencing.
Maria Elize van Breugel, Fred van Leeuwen

Methods Mol Biol· March 2022

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Signals for antigen-independent differentiation of memory CD8 T cells.
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen

Cell Mol Life Sci· October 2021

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Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies.
Leonie Kollenstart, Sophie C van der Horst, Kees Vreeken, George M C Janssen, Fabrizio Martino, Fred van Leeuwen

Sci Rep· June 2021

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Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
Muhammad Assad Aslam, Mir Farshid Alemdehy, Eliza Mari Kwesi-Maliepaard, Fitriari Izzatunnisa Muhaimin, Marieta Caganova, Fred van Leeuwen

EMBO Rep· February 2021

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Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells.
Thom M Molenaar, Marc Pagès-Gallego, Vanessa Meyn, Fred van Leeuwen

Epigenetics· September 2020

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Correction to: Somatic mutations in neurons during aging and neurodegeneration.
Bert M Verheijen, Marc Vermulst, Fred W van Leeuwen

Acta Neuropathol· September 2020

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Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains.
Bert M Verheijen, Satoru Morimoto, Ryogen Sasaki, Kiyomitsu Oyanagi, Yasumasa Kokubo, Fred W van Leeuwen

J Neuropathol Exp Neurol· August 2020

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The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8 T cells.
Eliza Mari Kwesi-Maliepaard, Muhammad Assad Aslam, Mir Farshid Alemdehy, Teun van den Brand, Chelsea McLean, Fred van Leeuwen

Proc Natl Acad Sci U S A· August 2020

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A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in .
Su Ming Sun, Amandine Batté, Mireille Elmer, Sophie C van der Horst, Tibor van Welsem, Fred van Leeuwen

J Cell Sci· May 2020

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Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.
Deepani W Poramba-Liyanage, Tessy Korthout, Christine E Cucinotta, Ila van Kruijsbergen, Tibor van Welsem, Fred van Leeuwen

Genome Res· April 2020

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Chromatin modified in a molecular reaction chamber.
Nick Gilbert, Fred van Leeuwen

Nature· March 2020

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Strategy for Development of Site-Specific Ubiquitin Antibodies.
Ila van Kruijsbergen, Monique P C Mulder, Michael Uckelmann, Tibor van Welsem, John de Widt, Fred van Leeuwen

Front Chem· February 2020

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