Publications by authors named "Frederic Becq"

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Peptide CIGB-552 has a synergistic effect on CFTR-F508del when combined with elexacaftor/tezacaftor/ivacaftor triple therapy for cystic fibrosis.
Benjamin Simonneau, Stéphanie Simon, Bénédicte Duriez, Aurélie Guguin, Frédéric Becq

Br J Pharmacol· December 2025

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Effect of elexacaftor and bamocaftor on the metabolic and thermal stability of the F508del-CFTR protein in human airway epithelial cells.
Thomas Carrez, Sandra Mirval, Christine Barrault, Florian Devetter, Clarisse Vandebrouck, Frédéric Becq

Am J Physiol Lung Cell Mol Physiol· November 2025

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Modeling ocular surface ion and water transport by generation of lipid- and mucin-producing human meibomian gland and conjunctival epithelial cells.
Chloë Radji, Christine Barrault, Roxane Flausse, Nicolas Leveziel, Anne Cantereau, Frédéric Becq

Am J Physiol Cell Physiol· March 2025

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The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca-mobilizing agonists normalizing abnormal Ca levels in human airway epithelial cells.
Manuella Lévêque, Sandra Mirval, Christine Barrault, Isabelle Fixe, Christelle Coraux, Frédéric Becq

Respir Res· December 2024

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ABC transporters involved in respiratory and cholestatic diseases: From rare to very rare monogenic diseases.
Mounia Lakli, Marion Onnée, Thomas Carrez, Frédéric Becq, Thomas Falguières

Biochem Pharmacol· November 2024

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The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor.
Frédéric Becq, Sandra Mirval, Thomas Carrez, Manuella Lévêque, Arnaud Billet

Eur Respir J· February 2022

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Engineered fluidic device to achieve multiplexed monitoring of cell cultures with digital holographic microscopy.
Erik Bélanger, Carine Benadiba, Émile Rioux-Pellerin, Frédéric Becq, Pascal Jourdain

Opt Express· January 2022

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[CFTR and cystic fibrosis, a 50-year long history].
Frédéric Becq

Med Sci (Paris)· December 2021

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Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension.
Hélène Le Ribeuz, Lucie To, Maria-Rosa Ghigna, Clémence Martin, Chandran Nagaraj, Frédéric Becq

Eur Respir J· November 2021

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Myelinosome Organelles in the Retina of R6/1 Huntington Disease (HD) Mice: Ubiquitous Distribution and Possible Role in Disease Spreading.
Marina G Yefimova, Emile Béré, Anne Cantereau-Becq, Annie-Claire Meunier-Balandre, Bruno Merceron, Frédéric Becq

Int J Mol Sci· November 2021

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Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells.
Chloé Grebert, Frédéric Becq, Clarisse Vandebrouck

Am J Physiol Lung Cell Mol Physiol· February 2021

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Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells.
Jodie Llinares, Anne Cantereau, Lionel Froux, Frédéric Becq

PLoS One· August 2020

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Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Lionel Froux, Ahmad Elbahnsi, Benjamin Boucherle, Arnaud Billet, Nesrine Baatallah, Frédéric Becq

Eur J Med Chem· March 2020

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Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R.
Arnaud Billet, Ahmad Elbahnsi, Mathilde Jollivet-Souchet, Brice Hoffmann, Jean-Paul Mornon, Frédéric Becq

Front Pharmacol· March 2020

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Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells.
Lionel Froux, Christelle Coraux, Edouard Sage, Frédéric Becq

Sci Rep· September 2019

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Focus on TRP channels in cystic fibrosis.
Chloé Grebert, Frederic Becq, Clarisse Vandebrouck

Cell Calcium· July 2019

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Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases.
Linette Kadri, Romain Ferru-Clément, Amélie Bacle, Laurie-Anne Payet, Anne Cantereau, Frédéric Becq

Biochim Biophys Acta Mol Basis Dis· September 2018

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Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.
Laurent Meijer, Deborah J Nelson, Vladimir Riazanski, Aida G Gabdoulkhakova, Geneviève Hery-Arnaud, Frédéric Becq

J Innate Immun· September 2017

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In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.
Raëd Farhat, Ayman El-Seedy, Ariestya Indah Permata Sari, Caroline Norez, Marie-Claude Pasquet, Frédéric Becq

C R Biol· August 2017

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The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.
Claire Chevaleyre, Mickaël Riou, Déborah Bréa, Clarisse Vandebrouck, Céline Barc, Frédéric Becq

PLoS One· July 2017

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Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.
Arnaud Billet, Lionel Froux, John W Hanrahan, Frederic Becq

Front Pharmacol· April 2017

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Calumenin contributes to ER-Ca homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.
Réginald Philippe, Fabrice Antigny, Paul Buscaglia, Caroline Norez, Florentin Huguet, Frédéric Becq

Cell Calcium· March 2017

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Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.
Marina G Yefimova, Emile Béré, Anne Cantereau-Becq, Thomas Harnois, Annie-Claire Meunier, Frédéric Becq

Hum Mol Genet· October 2016

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Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.
Romain Ferru-Clément, Miroslava Spanova, Shalinee Dhayal, Noel G Morgan, Reynald Hélye, Frédéric Becq

J Cell Sci· June 2016

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Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes.
Pierre-Antoine Nocquet, Raphaël Hensienne, Joanna Wencel-Delord, Eugénie Laigre, Khadidja Sidelarbi, Frédéric Becq

Org Biomol Chem· March 2016

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