Publications by authors named "Sandra Mirval"

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Peptide CIGB-552 has a synergistic effect on CFTR-F508del when combined with elexacaftor/tezacaftor/ivacaftor triple therapy for cystic fibrosis.
Benjamin Simonneau, Stéphanie Simon, Bénédicte Duriez, Aurélie Guguin, Frédéric Becq, Sandra Mirval

Br J Pharmacol· December 2025

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Effect of elexacaftor and bamocaftor on the metabolic and thermal stability of the F508del-CFTR protein in human airway epithelial cells.
Thomas Carrez, Sandra Mirval, Christine Barrault, Florian Devetter, Clarisse Vandebrouck

Am J Physiol Lung Cell Mol Physiol· November 2025

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The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca-mobilizing agonists normalizing abnormal Ca levels in human airway epithelial cells.
Manuella Lévêque, Sandra Mirval, Christine Barrault, Isabelle Fixe, Christelle Coraux

Respir Res· December 2024

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The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor.
Frédéric Becq, Sandra Mirval, Thomas Carrez, Manuella Lévêque, Arnaud Billet

Eur Respir J· February 2022

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Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Lionel Froux, Ahmad Elbahnsi, Benjamin Boucherle, Arnaud Billet, Nesrine Baatallah, Sandra Mirval

Eur J Med Chem· March 2020

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Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.
Laurie-Anne Payet, Linette Kadri, Sébastien Giraud, Caroline Norez, Jean Marc Berjeaud, Sandra Mirval

PLoS One· January 2015

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Recessive dystrophic epidermolysis bullosa caused by COL7A1 hemizygosity and a missense mutation with complex effects on splicing.
Matthias Titeux, José Enrique Mejía, Luciné Mejlumian, Sylvie Bourthoumieu, Sandra Mirval

Hum Mutat· March 2006

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