Publications by authors named "Frederic Ezan"

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Computerized predictive approaches of genotoxicity and mutagenesis in 3D Hepoid of normal and transformed human hepatocytes.
Sophie Rose, Frédéric Ezan, Ludovic Huot, Thierry Pécot, Medjda Bellamri

Toxicology· November 2025

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Hepatotoxicity of cyanotoxin microcystin-LR in human: Insights into mechanisms of action in the 3D culture model Hepoid-HepaRG.
Riju R Chowdhury, Sophie Rose, Frédéric Ezan, Iva Sovadinová, Pavel Babica

Environ Pollut· February 2024

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long term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application forengraftment.
Marie Cuvellier, Sophie Rose, Frédéric Ezan, Ulrich Jarry, Hugo de Oliveira

Biofabrication· June 2022

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DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies.
Sophie Rose, Marie Cuvellier, Frédéric Ezan, Jennifer Carteret, Arnaud Bruyère

Arch Toxicol· January 2022

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3D culture of HepaRG cells in GelMa and its application to bioprinting of a multicellular hepatic model.
Marie Cuvellier, Frédéric Ezan, Hugo Oliveira, Sophie Rose, Jean-Christophe Fricain

Biomaterials· February 2021

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Generation of proliferating human adult hepatocytes using optimized 3D culture conditions.
Sophie Rose, Frédéric Ezan, Marie Cuvellier, Arnaud Bruyère, Vincent Legagneux

Sci Rep· January 2021

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Wavy nature of collagen fibrils deduced from the dispersion of their second-order nonlinear optical anisotropy parameters ρ.
Denis Rouède, Emmanuel Schaub, Jean-Jacques Bellanger, Frédéric Ezan, François Tiaho

Opt Express· February 2020

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Staphylococcus aureus induces DNA damage in host cell.
Martine Deplanche, Nassim Mouhali, Minh-Thu Nguyen, Chantal Cauty, Frédéric Ezan

Sci Rep· May 2019

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Determination of extracellular matrix collagen fibril architectures and pathological remodeling by polarization dependent second harmonic microscopy.
Denis Rouède, Emmanuel Schaub, Jean-Jacques Bellanger, Frédéric Ezan, Jean-Claude Scimeca

Sci Rep· September 2017

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[1-9-NαC]-crourorb A1 isolated from Croton urucurana latex induces G2/M cell cycle arrest and apoptosis in human hepatocarcinoma cells.
Priscila de Matos Cândido-Bacani, Frédéric Ezan, Patrícia de Oliveira Figueiredo, Maria de Fátima Cepa Matos, Fernanda Rodrigues Garcez

Toxicol Lett· May 2017

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Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment.
Jérémy Bomo, Frédéric Ezan, François Tiaho, Medjda Bellamri, Sophie Langouët

J Cell Biochem· March 2016

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Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells.
Philippe Nizard, Frédéric Ezan, Dominique Bonnier, Nolwenn Le Meur, Sophie Langouët

BMC Genomics· December 2014

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MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K.
Jean-Philippe Guégan, Frédéric Ezan, Luc Gailhouste, Sophie Langouët, Georges Baffet

J Cell Physiol· July 2014

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MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells.
Jean-Philippe Guégan, Frédéric Ezan, Nathalie Théret, Sophie Langouët, Georges Baffet

Carcinogenesis· January 2013

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TRAIL but not FasL and TNFα, regulates IL-33 expression in murine hepatocytes during acute hepatitis.
Muhammad Imran Arshad, Claire Piquet-Pellorce, Annie L'Helgoualc'h, Michel Rauch, Solène Patrat-Delon, Frédéric Ezan

Hepatology· December 2012

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Overexpression of active Aurora-C kinase results in cell transformation and tumour formation.
Jabbar Khan, Frédéric Ezan, Jean-Yves Crémet, Alain Fautrel, David Gilot

PLoS One· March 2012

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The complexity of ERK1 and ERK2 MAPKs in multiple hepatocyte fate responses.
Christophe Frémin, Frédéric Ezan, Jean-Philippe Guegan, Luc Gailhouste, Maud Trotard

J Cell Physiol· January 2012

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Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta.
Katia Bourd-Boittin, Dominique Bonnier, Anthony Leyme, Bernard Mari, Pierre Tuffery, Frédéric Ezan

Hepatology· December 2011

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The knock-down of ERCC1 but not of XPF causes multinucleation.
Julie Rageul, Christophe Frëmin, Frédéric Ezan, Georges Baffet, Sophie Langouët

DNA Repair (Amst)· September 2011

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RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo.
Luc Gailhouste, Frédéric Ezan, Anne Bessard, Christophe Frémin, Julie Rageul

Int J Cancer· March 2010

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Fibrillar collagen scoring by second harmonic microscopy: a new tool in the assessment of liver fibrosis.
Luc Gailhouste, Yann Le Grand, Christophe Odin, Dominique Guyader, Bruno Turlin, Frédéric Ezan

J Hepatol· March 2010

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Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2.
Christophe Frémin, Anne Bessard, Frédéric Ezan, Luc Gailhouste, Morgane Régeard

Hepatology· March 2009

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MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells.
Anne Bessard, Christophe Frémin, Frédéric Ezan, Alexandre Coutant, Georges Baffet

J Cell Physiol· August 2007

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ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes.
Christophe Frémin, Frédéric Ezan, Pierre Boisselier, Anne Bessard, Gilles Pagès

Hepatology· April 2007

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An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway.
Anne Bessard, Alexandre Coutant, Claude Rescan, Frédéric Ezan, Christophe Frémin

Hepatology· July 2006

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