Publications by authors named "Frederic Kaye"

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Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability.
Miao Huang, Yinong Chen, Chenyu Liang, Om Prakash Narayan, Chase Stallings, Frederic J Kaye

Biomaterials· December 2025

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Integrated proteomic analysis identifies TYMS-dependent AMPK-mTOR signaling in pancreatic neuroendocrine tumors.
Vinod Vijayakurup, Benjamin Meyer, Syeda Rida Rizvi, Kara H Kievit, Iram Hyder, Frederic J Kaye, Maria Zajac-Kaye

iScience· November 2025

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Proof-of-Concept of an Integrated Yoga and Psychological Intervention in Mitigating Distress Among Diverse Women With Gynecologic, Gastrointestinal, and Thoracic Cancers.
Grace Ann Hanvey, Elizabeth L Kacel, Kelsey C Bacharz, Adaixa Padrón Wilborn, Sonia Mesa, Frederic J Kaye

Integr Cancer Ther· October 2024

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PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer.
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J Kaye

bioRxiv· March 2024

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PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer.
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J Kaye

Cells· March 2024

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Nivolumab monotherapy or combination with ipilimumab with or without cobimetinib in previously treated patients with pancreatic adenocarcinoma (CheckMate 032).
Margaret Callahan, Asim Amin, Frederic J Kaye, Michael A Morse, Matthew H Taylor

J Immunother Cancer· February 2024

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Disparities Contributing to Late-Stage Diagnosis of Lung, Colorectal, Breast, and Cervical Cancers: Rural and Urban Poverty in Florida.
Jaclyn M Hall, Rahma S Mkuu, Hee Deok Cho, Jennifer N Woodard, Frederic J Kaye

Cancers (Basel)· October 2023

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TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background.
Maria V Guijarro, Akbar Nawab, Peter Dib, Sandra Burkett, Xiaoping Luo, Frederic J Kaye, Maria Zajac-Kaye

Oncogene· June 2023

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First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival.
Maria V Guijarro, Patrick C Kellish, Peter E Dib, Nicholas G Paciaroni, Akbar Nawab, Frederic J Kaye, Maria Zajac-Kaye

JCI Insight· April 2023

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PROTAC therapy as a new targeted therapy for lung cancer.
Jennifer W Li, Guangrong Zheng, Frederic J Kaye, Lizi Wu

Mol Ther· March 2023

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Co-targeting BCL-X and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice.
Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri, Janet Wiegand, Maria Zajac-Kaye, Frederic J Kaye

Cell Death Discov· January 2023

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Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival.
Vinod Vijayakurup, Kyungah Maeng, Hye Seung Lee, Benjamin Meyer, Sandra Burkett, Frederic J Kaye, Maria Zajac-Kaye

JCI Insight· October 2022

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Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational study.
Dejana Braithwaite, Shama D Karanth, Christopher G Slatore, Dongyu Zhang, Jiang Bian, Frederic J Kaye

BMJ Open· June 2022

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Managing stage 4 ameloblastoma with dual BRAF/MEK inhibition: A case report with 8-year clinical follow-up.
Zachary Abramson, Orrin L Dayton, Walter E Drane, William M Mendenhall, Frederic J Kaye

Oral Oncol· May 2022

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Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming-A New Mechanism for SCLC Chemoresistance Boosted by Nicotine.
Yuzhi Wang, Tengfei Bian, Lina Song, Yunhan Jiang, Zhiguang Huo, Frederic J Kaye

Cancers (Basel)· May 2022

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BCL-X PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRAS-mutated cancers.
Sajid Khan, Janet Wiegand, Peiyi Zhang, Wanyi Hu, Dinesh Thummuri, Maria Zajac-Kaye, Frederic J Kaye

J Hematol Oncol· March 2022

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Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial.
Benjamin C Creelan, Chao Wang, Jamie K Teer, Eric M Toloza, Jiqiang Yao, Frederic J Kaye

Nat Med· August 2021

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Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation.
Xin Zhou, Jennifer W Li, Zirong Chen, Wei Ni, Xuehui Li, Frederic J Kaye

Elife· June 2021

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The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma.
Zirong Chen, Wei Ni, Jian-Liang Li, Shuibin Lin, Xin Zhou, Frederic J Kaye

JCI Insight· April 2021

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Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma.
Wei Ni, Zirong Chen, Xin Zhou, Rongqiang Yang, Mu Yu, Frederic J Kaye

Signal Transduct Target Ther· January 2021

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Delta-Like Protein 3 Expression and Targeting in Merkel Cell Carcinoma.
Hao Xie, Frederic J Kaye, Kumiko Isse, Yan Sun, Johanna Ramoth

Oncologist· September 2020

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SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Review of Literature.
Brian D Stewart, Frederic Kaye, Tiago Machuca, Hiren J Mehta, Tan-Lucien Mohammed

Int J Surg Pathol· February 2020

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Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.
Julia K Rotow, Philippe Gui, Wei Wu, Victoria M Raymond, Richard B Lanman, Frederic J Kaye

Clin Cancer Res· January 2020

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MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma.
Yue Jiang, Ruli Gao, Chunxia Cao, Lauren Forbes, Jianping Li, Maria Zajac-Kaye, Frederic J Kaye

Oral Oncol· November 2019

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Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival.
Patrick Kellish, Daniil Shabashvili, Masmudur M Rahman, Akbar Nawab, Maria V Guijarro, Frederic J Kaye, Maria Zajac-Kaye

J Clin Invest· April 2019

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