Publications by authors named "Frederick Alt"

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Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency.
Jianli Tao, Luca Alessandri, Alessandro Gasparetto, Lijuan Zhao, Xuefei Zhang, Frederick W Alt

Blood· October 2025

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Editorial Expression of Concern: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Kwok-Kin Wong, Richard S Maser, Robert M Bachoo, Jayant Menon, Daniel R Carrasco, Frederick W Alt

Nature· February 2025

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Orientation Regulation of Class-switch Recombination in Human B Cells.
Likun Du, Valentyn Oksenych, Hui Wan, Xiaofei Ye, Junchao Dong, Frederick W Alt

J Immunol· October 2024

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Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs.
Zekun Mu, Jill Whitley, Diana Martik, Laura Sutherland, Amanda Newman, Frederick W Alt

J Virol· September 2024

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Corrigendum: Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency.
Francesca Rucci, Pietro Luigi Poliani, Stefano Caraffi, Tiziana Paganini, Elena Fontana, Frederick W Alt

Front Immunol· September 2024

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Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.
Tom G Caniels, Max Medina-Ramìrez, Shiyu Zhang, Sven Kratochvil, Yuejiao Xian, Frederick W Alt

Sci Immunol· August 2024

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Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Torben Schiffner, Ivy Phung, Rashmi Ray, Adriana Irimia, Ming Tian, Frederick W Alt

Nat Immunol· July 2024

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Molecular basis for differential Igk versus Igh V(D)J joining mechanisms.
Yiwen Zhang, Xiang Li, Zhaoqing Ba, Jiangman Lou, K Elyse Gaertner, Frederick W Alt

Nature· June 2024

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Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Torben Schiffner, Ivy Phung, Rashmi Ray, Adriana Irimia, Ming Tian, Frederick W Alt

Nat Immunol· June 2024

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Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.
Kevin Wiehe, Kevin O Saunders, Victoria Stalls, Derek W Cain, Sravani Venkatayogi, Frederick W Alt

Cell Host Microbe· May 2024

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Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice.
Christopher A Cottrell, Xiaozhen Hu, Jeong Hyun Lee, Patrick Skog, Sai Luo, Frederick W Alt

Sci Transl Med· May 2024

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The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity.
Pankaj Sharma, Xiaolong Zhang, Kevin Ly, Yuxiang Zhang, Yu Hu, Frederick W Alt

Science· February 2024

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The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity.
Pankaj Sharma, Xiaolong Zhang, Kevin Ly, Yuxiang Zhang, Yu Hu, Frederick W Alt

bioRxiv· September 2023

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Contribution of the IGCR1 regulatory element and the 3' CTCF-binding elements to regulation of V(D)J recombination.
Zhuoyi Liang, Lijuan Zhao, Adam Yongxin Ye, Sherry G Lin, Yiwen Zhang, Frederick W Alt

Proc Natl Acad Sci U S A· June 2023

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Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation.
Yanyan Wang, Senxin Zhang, Xinrui Yang, Joyce K Hwang, Chuanzong Zhan, Frederick W Alt

Cell· May 2023

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Author Correction: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.
Barton F Haynes, Kevin Wiehe, Persephone Borrow, Kevin O Saunders, Bette Korber, Frederick Alt

Nat Rev Immunol· April 2023

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Contribution of the IGCR1 regulatory element and the 3 CBEs to Regulation of V(D)J Recombination.
Zhuoyi Liang, Lijuan Zhao, Adam Yongxin Ye, Sherry G Lin, Yiwen Zhang, Frederick W Alt

bioRxiv· April 2023

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Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.
Barton F Haynes, Kevin Wiehe, Persephone Borrow, Kevin O Saunders, Bette Korber, Frederick Alt

Nat Rev Immunol· March 2023

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Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors.
Sai Luo, Changbin Jing, Adam Yongxin Ye, Sven Kratochvil, Christopher A Cottrell, Frederick W Alt

Proc Natl Acad Sci U S A· January 2023

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Structural principles of B cell antigen receptor assembly.
Ying Dong, Xiong Pi, Frauke Bartels-Burgahn, Deniz Saltukoglu, Zhuoyi Liang, Frederick W Alt

Nature· December 2022

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An antibody from single human V-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.
Sai Luo, Jun Zhang, Alex J B Kreutzberger, Amanda Eaton, Robert J Edwards, Frederick W Alt

Sci Immunol· October 2022

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C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency.
Xia Xie, Tingting Gan, Bing Rao, Weiwei Zhang, Rohit A Panchakshari, Frederick W Alt

EMBO J· June 2022

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Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination.
Chloé Oudinet, Xuefei Zhang, Nadine Puget, Nia Kyritsis, Claire Leduc, Frederick W Alt

Front Immunol· June 2022

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SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Frederick W Alt

Nat Commun· June 2022

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mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.
Zekun Mu, Kevin Wiehe, Kevin O Saunders, Rory Henderson, Derek W Cain, Frederick W Alt

Cell Rep· March 2022

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