Publications by authors named "Frederick Dewey"

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Identification of candidate cardiomyopathy modifier genes through genome sequencing and RNA profiling.
Malene E Lindholm, Sarah Abramowitz, Daryl M Waggott, Megan E Grove, Frederick E Dewey

Front Cardiovasc Med· July 2025

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Identification of NUV-244 as a PNPLA3 I148M degrading small molecule.
Patrick Steigemann, Nico Braeuer, Vera Puetter, Nina Zablowsky, Katrin Juenemann, Frederick E Dewey

iScience· May 2025

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Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
Hannah N De Jong, Frederick E Dewey, Pablo Cordero, Rachelle A Victorio, Anna Kirillova

Circ Genom Precis Med· August 2022

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Correction to: Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants.
Adam H Buchanan, Kandamurugu Manickam, Michelle N Meyer, Jennifer K Wagner, Miranda L G Hallquist, Frederick E Dewey

Genet Med· December 2021

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Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.
Christopher M Haggerty, Scott M Damrauer, Michael G Levin, David Birtwell, David J Carey, Frederick E Dewey

Circulation· July 2019

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Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Jason Flannick, Josep M Mercader, Christian Fuchsberger, Miriam S Udler, Anubha Mahajan, Frederick E Dewey

Nature· June 2019

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Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
Pablo Cordero, Victoria N Parikh, Elizabeth T Chin, Ayca Erbilgin, Michael J Gloudemans, Frederick Dewey

Nat Commun· June 2019

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Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease.
Gina M Peloso, Akihiro Nomura, Amit V Khera, Mark Chaffin, Hong-Hee Won, Frederick E Dewey

Circ Genom Precis Med· May 2019

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Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis.
Yoko Kojima, Kelly Downing, Ramendra Kundu, Clint Miller, Frederick Dewey

J Clin Invest· May 2019

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Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
Seung Hoan Choi, Lu-Chen Weng, Carolina Roselli, Honghuang Lin, Christopher M Haggerty, Frederick E Dewey

JAMA· December 2018

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Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Derek Klarin, Scott M Damrauer, Kelly Cho, Yan V Sun, Tanya M Teslovich, Frederick E Dewey

Nat Genet· November 2018

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Author Correction: Rare variants in drug target genes contributing to complex diseases, phenome-wide.
Shefali Setia Verma, Navya Josyula, Anurag Verma, Xinyuan Zhang, Yogasudha Veturi, Frederick E Dewey

Sci Rep· October 2018

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Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.
Michael S Bohnen, Lijiang Ma, Na Zhu, Hongjian Qi, Conor McClenaghan, Frederick E Dewey

Circ Genom Precis Med· October 2018

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Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Jonas B Nielsen, Rosa B Thorolfsdottir, Lars G Fritsche, Wei Zhou, Morten W Skov, Frederick E Dewey

Nat Genet· September 2018

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Exome Sequencing-Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants.
Kandamurugu Manickam, Adam H Buchanan, Marci L B Schwartz, Miranda L G Hallquist, Janet L Williams, Frederick E Dewey

JAMA Netw Open· September 2018

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APPLICATIONS OF GENETICS, GENOMICS AND BIOINFORMATICS IN DRUG DISCOVERY.
Richard Bourgon, Frederick E Dewey, Zhengyan Kan, Shuyu D Li

Pac Symp Biocomput· August 2018

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Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease.
Na Zhu, Carrie L Welch, Jiayao Wang, Philip M Allen, Claudia Gonzaga-Jauregui, Frederick E Dewey

Genome Med· July 2018

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Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.
Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, Frederick E Dewey

Nat Commun· June 2018

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Profiling and Leveraging Relatedness in a Precision Medicine Cohort of 92,455 Exomes.
Jeffrey Staples, Evan K Maxwell, Nehal Gosalia, Claudia Gonzaga-Jauregui, Christopher Snyder, Frederick E Dewey

Am J Hum Genet· May 2018

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Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants.
Adam H Buchanan, Kandamurugu Manickam, Michelle N Meyer, Jennifer K Wagner, Miranda L G Hallquist, Frederick E Dewey

Genet Med· April 2018

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Exome Sequencing in Children With Pulmonary Arterial Hypertension Demonstrates Differences Compared With Adults.
Na Zhu, Claudia Gonzaga-Jauregui, Carrie L Welch, Lijiang Ma, Hongjian Qi, Frederick Dewey

Circ Genom Precis Med· April 2018

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Rare variants in drug target genes contributing to complex diseases, phenome-wide.
Shefali Setia Verma, Navya Josyula, Anurag Verma, Xinyuan Zhang, Yogasudha Veturi, Frederick E Dewey

Sci Rep· March 2018

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A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.
Noura S Abul-Husn, Xiping Cheng, Alexander H Li, Yurong Xin, Claudia Schurmann, Frederick E Dewey

N Engl J Med· March 2018

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Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.
Jonas B Nielsen, Lars G Fritsche, Wei Zhou, Tanya M Teslovich, Oddgeir L Holmen, Frederick E Dewey

Am J Hum Genet· January 2018

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MAPPIN: a method for annotating, predicting pathogenicity and mode of inheritance for nonsynonymous variants.
Nehal Gosalia, Aris N Economides, Frederick E Dewey, Suganthi Balasubramanian

Nucleic Acids Res· October 2017

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