Publications by authors named "Frederick Lahser"

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Interim analysis of a 3-year follow-up study of NS5A and NS3 resistance-associated substitutions after treatment with grazoprevir-containing regimens in participants with chronic HCV infection.
Frederick Lahser, Angela Galloway, Peggy Hwang, John Palcza, Joann Brunhofer

Antivir Ther· September 2019

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Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A.
Ernest Asante-Appiah, Rong Liu, Stephanie Curry, Patricia McMonagle, Sony Agrawal, Frederick Lahser

Antimicrob Agents Chemother· November 2018

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Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.
Wensheng Yu, Ling Tong, Oleg Selyutin, Lei Chen, Bin Hu, Frederick Lahser

J Med Chem· May 2018

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Antiviral Activity and Resistance Analysis of NS3/4A Protease Inhibitor Grazoprevir and NS5A Inhibitor Elbasvir in Hepatitis C Virus GT4 Replicons.
Ernest Asante-Appiah, Stephanie Curry, Patricia McMonagle, Paul Ingravallo, Robert Chase, Frederick C Lahser

Antimicrob Agents Chemother· July 2017

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Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms.
Ling Tong, Wensheng Yu, Lei Chen, Oleg Selyutin, Michael P Dwyer, Frederick Lahser

J Med Chem· January 2017

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PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally.
Jason D Graci, Stephen P Jung, John Pichardo, Frederick Lahser, Xiao Tong

Antimicrob Agents Chemother· December 2016

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Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.
Ling Tong, Wensheng Yu, Craig A Coburn, Lei Chen, Oleg Selyutin, Frederick Lahser

Bioorg Med Chem Lett· November 2016

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The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons.
Frederick C Lahser, Karin Bystol, Stephanie Curry, Patricia McMonagle, Ellen Xia

Antimicrob Agents Chemother· May 2016

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Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.
David R McGivern, Takahiro Masaki, Sara Williford, Paul Ingravallo, Zongdi Feng, Frederick Lahser

Gastroenterology· August 2014

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Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein.
Zhengxian Gu, Jason D Graci, Frederick C Lahser, Jamie J Breslin, Stephen P Jung

Antimicrob Agents Chemother· July 2013

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A continuous nonradioactive assay for RNA-dependent RNA polymerase activity.
Frederick C Lahser, Bruce A Malcolm

Anal Biochem· February 2004

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Conserved C-terminal threonine of hepatitis C virus NS3 regulates autoproteolysis and prevents product inhibition.
Wenyan Wang, Frederick C Lahser, MinKyung Yi, Jacquelyn Wright-Minogue, Ellen Xia

J Virol· January 2004

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Quantitative estimation of viral fitness using Pyrosequencing.
Frederick C Lahser, Jacquelyn Wright-Minogue, Angela Skelton, Bruce A Malcolm

Biotechniques· January 2003

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