Publications by authors named "Jason D Graci"

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Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia.
Arthur Branstrom, Liangxian Cao, Bansri Furia, Christopher Trotta, Marianne Santaguida, Jason D Graci

Front Oncol· February 2022

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Small molecule splicing modifiers with systemic HTT-lowering activity.
Anuradha Bhattacharyya, Christopher R Trotta, Jana Narasimhan, Kari J Wiedinger, Wencheng Li, Jason D Graci

Nat Commun· December 2021

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines.
Jeremy Luban, Rachel A Sattler, Elke Mühlberger, Jason D Graci, Liangxian Cao

Virus Res· January 2021

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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines.
Jeremy Luban, Rachel Sattler, Elke Mühlberger, Jason D Graci, Liangxian Cao

bioRxiv· August 2020

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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.
Liangxian Cao, Marla Weetall, Christopher Trotta, Katherine Cintron, Jiyuan Ma, Jason D Graci

Mol Cancer Ther· January 2019

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Identification of benzazole compounds that induce HIV-1 transcription.
Jason D Graci, Daniel Michaels, Guangming Chen, Gillian M Schiralli Lester, Sarah Nodder

PLoS One· September 2017

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PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally.
Jason D Graci, Stephen P Jung, John Pichardo, Frederick Lahser, Xiao Tong

Antimicrob Agents Chemother· December 2016

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RNA virus population diversity, an optimum for maximal fitness and virulence.
Victoria K Korboukh, Cheri A Lee, Ashley Acevedo, Marco Vignuzzi, Yinghong Xiao, Jason D Graci

J Biol Chem· October 2014

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Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein.
Zhengxian Gu, Jason D Graci, Frederick C Lahser, Jamie J Breslin, Stephen P Jung

Antimicrob Agents Chemother· July 2013

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Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.
Jason D Graci, Nina F Gnädig, Jessica E Galarraga, Christian Castro, Marco Vignuzzi

J Virol· March 2012

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High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.
Sofiya Micheva-Viteva, Yoshifumi Kobayashi, Leonard C Edelstein, Annmarie L Pacchia, Hui-Ling Rose Lee, Jason D Graci

J Biol Chem· June 2011

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HIV type-1 latency: targeted induction of proviral reservoirs.
Jason D Graci, Joseph M Colacino, Stuart W Peltz, Joseph P Dougherty, Zhengxian Gu

Antivir Chem Chemother· February 2010

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Therapeutically targeting RNA viruses via lethal mutagenesis.
Jason D Graci, Craig E Cameron

Future Virol· November 2008

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Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.
Jason D Graci, Kathleen Too, Eric D Smidansky, Jocelyn P Edathil, Eric W Barr

Antimicrob Agents Chemother· March 2008

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Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity.
Kei Moriyama, Tetsuya Suzuki, Kazuo Negishi, Jason D Graci, Corinne N Thompson

J Med Chem· January 2008

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Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.
Jason D Graci, Daniel A Harki, Victoria S Korneeva, Jocelyn P Edathil, Kathleen Too

J Virol· October 2007

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Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase.
Daniel A Harki, Jason D Graci, Jocelyn P Edathil, Christian Castro, Craig E Cameron

Chembiochem· August 2007

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Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.
Daniel A Harki, Jason D Graci, Jessica E Galarraga, William J Chain, Craig E Cameron

J Med Chem· October 2006

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Mechanisms of action of ribavirin against distinct viruses.
Jason D Graci, Craig E Cameron

Rev Med Virol· March 2006

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Challenges for the development of ribonucleoside analogues as inducers of error catastrophe.
Jason D Graci, Craig E Cameron

Antivir Chem Chemother· January 2004

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Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.
Daniel A Harki, Jason D Graci, Victoria S Korneeva, Saikat Kumar B Ghosh, Zhi Hong

Biochemistry· July 2002

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Quasispecies, error catastrophe, and the antiviral activity of ribavirin.
Jason D Graci, Craig E Cameron

Virology· July 2002

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