Publications by authors named "Fumito Wada"

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Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency.
Junsuke Hayashi, Yosuke Ochi, Kota Senpuku, Shun-Ichi Wada, Fumito Wada

Bioorg Med Chem· April 2024

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Prodrug-Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment.
Norihito Sugimoto, Junsuke Hayashi, Ryohei Funaki, Shun-Ichi Wada, Fumito Wada

Chembiochem· December 2023

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Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides.
Chisato Terada, Fumito Wada, Mei Uchida, Yukari Yasutomi, Kaho Oh

Nucleic Acid Ther· December 2021

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Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides.
Fumito Wada, Tsuyoshi Yamamoto, Tadayuki Kobayashi, Keisuke Tachibana, Kosuke Ramon Ito

Mol Ther Nucleic Acids· December 2021

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Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides.
Tsuyoshi Yamamoto, Yahiro Mukai, Fumito Wada, Chisato Terada, Yukina Kayaba

Pharmaceutics· May 2021

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Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility.
Fumito Wada, Shin-Ichiro Hori, Satoshi Obika, Tsuyoshi Yamamoto

Methods Mol Biol· March 2021

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Effect of modular conjugation strategy for -acetylgalactosamine-targeted antisense oligonucleotides.
Tsuyoshi Yamamoto, Motoki Sawamura, Chisato Terada, Koki Kashiwada, Fumito Wada

Nucleosides Nucleotides Nucleic Acids· September 2020

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Effective gene silencing activity of prodrug-type 2'-O-methyldithiomethyl siRNA compared with non-prodrug-type 2'-O-methyl siRNA.
Junsuke Hayashi, Misa Nishigaki, Yosuke Ochi, Shun-Ichi Wada, Fumito Wada

Bioorg Med Chem Lett· July 2018

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Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.
Fumito Wada, Tsuyoshi Yamamoto, Tetsuya Ueda, Motoki Sawamura, Shunsuke Wada

Nucleic Acid Ther· February 2018

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Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes.
Kiyoko Setoguchi, Lin Cui, Nobutaka Hachisuka, Sumalee Obchoei, Kentaro Shinkai, Fumito Wada

Mol Ther Nucleic Acids· December 2017

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Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged thymidine derivatives.
Takashi Osawa, Motoki Sawamura, Fumito Wada, Tsuyoshi Yamamoto, Satoshi Obika

Org Biomol Chem· May 2017

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Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.
Yasunori Mitsuoka, Tsuyoshi Yamamoto, Akira Kugimiya, Reiko Waki, Fumito Wada

J Org Chem· January 2017

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Development of Antisense Drugs for Dyslipidemia.
Tsuyoshi Yamamoto, Fumito Wada, Mariko Harada-Shiba

J Atheroscler Thromb· September 2016

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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure.
Yasunori Mitsuoka, Hiroshi Aoyama, Akira Kugimiya, Yuko Fujimura, Tsuyoshi Yamamoto, Fumito Wada

Org Biomol Chem· July 2016

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Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides.
Shunsuke Wada, Hidenori Yasuhara, Fumito Wada, Motoki Sawamura, Reiko Waki

J Control Release· March 2016

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Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.
Tsuyoshi Yamamoto, Motoki Sawamura, Fumito Wada, Mariko Harada-Shiba, Satoshi Obika

Bioorg Med Chem· January 2016

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Ca2+ enrichment in culture medium potentiates effect of oligonucleotides.
Shin-Ichiro Hori, Tsuyoshi Yamamoto, Reiko Waki, Shunsuke Wada, Fumito Wada

Nucleic Acids Res· October 2015

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Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo.
Tsuyoshi Yamamoto, Aiko Yahara, Reiko Waki, Hidenori Yasuhara, Fumito Wada

Org Biomol Chem· March 2015

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Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.
Tsuyoshi Yamamoto, Naoko Fujii, Hidenori Yasuhara, Shunsuke Wada, Fumito Wada

Nucleic Acid Ther· August 2014

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Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma.
Tsuyoshi Yamamoto, Satoshi Obika, Moeka Nakatani, Hidenori Yasuhara, Fumito Wada

Eur J Pharmacol· January 2014

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Superior Silencing by 2',4'-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors.
Tsuyoshi Yamamoto, Hidenori Yasuhara, Fumito Wada, Mariko Harada-Shiba, Takeshi Imanishi

J Nucleic Acids· October 2012

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