Publications by authors named "Satoshi Obika"

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Hydrophilic additives enhancing electrospray ionization of oligonucleotides in hexafluoro-2-propanol-free reversed-phase ion-pair liquid chromatography/mass spectrometry.
Takashi Miyazaki, Natsuyo Asano, Satoshi Yamaki, Takao Yamaguchi, Satoshi Obika

J Chromatogr A· January 2026

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Theoretical calculation of the amounts of nucleotide deletion impurities in oligonucleotides.
Yasunori Uchida, Tokuyuki Yoshida, Emi Saito, Hirokazu Nankai, Kaoru Karasawa, Satoshi Obika

Int J Pharm· January 2026

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Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer.
Masaru Tani, Koji Hatano, Yu Ishizuya, Toshiki Oka, Tomohiro Kanaki, Satoshi Obika

Cancer Sci· December 2025

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Development of Synthetic Routes to 2'-O,4'-C-Spirocyclopentylene-Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine.
Riku Kumagai, Riko Yamada, Takao Yamaguchi, Satoshi Obika

Chemistry· December 2025

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Antisense oligonucleotide targeting the E3 ligase RFFL potentiates CFTR modulator efficacy in CF primary bronchial epithelial cells.
Daichi Hinata, Yukari Kai, Ryosuke Fukuda, Yuka Kamada, Yuuya Kasahara, Satoshi Obika

Mol Ther Nucleic Acids· December 2025

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Sequence-dependent RNA cleavage by the 8-17 DNAzyme: Identification of preferred tetranucleotide motifs.
Satoko Nakajima, Shuhei Miyakawa, Shu Ohno, Haruki Ikemoto, Rikuto Maruyama, Satoshi Obika

Bioorg Med Chem· December 2025

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Current trends in liquid chromatography-mass spectrometry analysis of small interfering RNAs: A short review.
Hiroyuki Togawa, Takao Yamaguchi, Junji Kawakami, Satoshi Obika

J Chromatogr A· November 2025

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Rational design of a covalent ACE2 decoy receptor that broadly neutralizes SARS-CoV-2 variants.
Nobumasa Hino, Risa Takada, Kyosuke Suzuki, Nagisa Tokunoh, Tatsuya Karaki, Satoshi Obika

Protein Sci· October 2025

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Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides.
Takao Yamaguchi, Hibiki Komine, Takaya Sugiura, Riku Kumagai, Tokuyuki Yoshida, Satoshi Obika

JACS Au· October 2025

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MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration.
Naoya Sowa, Takahiro Horie, Yuya Ide, Osamu Baba, Kengo Kora, Satoshi Obika

EMBO Mol Med· August 2025

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Phthalimide: a potential warhead for switchable and bioorthogonal conjugation.
Kosuke Chiba, Takumi Yoshida, Kana Okada, Minoru Ishikawa, Yuichi Hashimoto, Satoshi Obika

Chem Commun (Camb)· August 2025

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Optimization of 2',4'-BNA/LNA-Based Oligonucleotides for Splicing Modulation in Vitro.
Takenori Shimo, Satoshi Obika

Methods Mol Biol· July 2025

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Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects.
Tomoaki Hara, Sikun Meng, Yuuya Kasahara, Takashi Osawa, Daisuke Motooka, Satoshi Obika

Mol Ther Nucleic Acids· June 2025

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Separation of deaminated impurities from the desired oligonucleotides using supercritical fluid chromatography.
Momoka Hayashida, Risa Suzuki, Shinnosuke Horie, Junichi Masuda, Takao Yamaguchi, Satoshi Obika

J Chromatogr A· March 2025

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Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides.
Takenori Shimo, Juri Hasegawa, Kotaro Yoshioka, Yusuke Nakatsuji, Kotomi Aso, Satoshi Obika

Mol Ther Nucleic Acids· March 2025

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Synthesis and structural analysis of dinucleotides containing 2',3'-trans-bridged nucleic acids with trans-5,6- or 5,7-fused ring skeleton.
Takashi Osawa, Ryota Nakanishi, Keito Uda, So Muramoto, Satoshi Obika

Commun Chem· March 2025

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Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides.
Kohshi Kusumoto, Kiyomi Sasaki, Yasunori Uchida, Ayaka Utsumi, Tokuyuki Yoshida, Satoshi Obika

Sci Rep· January 2025

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Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.
Mitsuro Kanda, Nao Takano, Hiroshi Miyauchi, Kohei Ueda, Masaaki Mizuno, Satoshi Obika

Gastric Cancer· November 2024

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Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer.
Mitsuro Kanda, Yuuya Kasahara, Dai Shimizu, Takahiro Shinozuka, Masahiro Sasahara, Satoshi Obika

Br J Cancer· November 2024

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Separation and Characterization of Therapeutic Oligonucleotide Isomer Impurities by Cyclic Ion Mobility Mass Spectrometry.
Shogo Omuro, Takao Yamaguchi, Taiji Kawase, Kenji Hirose, Tokuyuki Yoshida, Satoshi Obika

J Am Soc Mass Spectrom· September 2024

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Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer.
Keishiro Mishima, Satoshi Obika, Masahito Shimojo

Mol Ther Nucleic Acids· September 2024

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In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity.
Takashi Osawa, Ryosuke Kita, Yuuya Kasahara, Harumi Yamaguma, Taisuke Nakayama, Satoshi Obika

Bioorg Med Chem· August 2024

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THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides.
Qin Ren, Takashi Osawa, Michiaki Tatsuno, Satoshi Obika

RSC Adv· July 2024

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Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine.
Taiki Matsubayashi, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Chunyan Jia, Satoshi Obika

Mol Ther Nucleic Acids· June 2024

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Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.
Tokuyuki Yoshida, Tomoko Hagihara, Yasunori Uchida, Yoshiyuki Horiuchi, Kiyomi Sasaki, Satoshi Obika

Sci Rep· May 2024

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