Publications by authors named "Gabriel Robbie"

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Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules.
Prajakta Badri, Kiranmai Kolachana, Anh Duong, Maxwell Lasko, Tirtha Nandi, Gabriel J Robbie

Clin Pharmacokinet· December 2025

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Pharmacokinetics and Pharmacodynamics of Patisiran in Patients with hATTR Amyloidosis and with Polyneuropathy After Liver Transplantation.
Prajakta Badri, Bahru Habtemariam, Megan Melch, Valerie A Clausen, Seth Arum, Gabriel J Robbie

Clin Pharmacokinet· October 2023

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Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension.
Akshay S Desai, David J Webb, Jorg Taubel, Sarah Casey, Yansong Cheng, Gabriel J Robbie

N Engl J Med· July 2023

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Pharmacokinetic-pharmacodynamic model of urinary δ-aminolevulinic acid reduction after givosiran treatment in patients with acute hepatic porphyria.
Jongtae Lee, Megan Melch, Gabriel J Robbie

CPT Pharmacometrics Syst Pharmacol· June 2023

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Quantification of oxalate by novel LC-MS/MS: assay development, validation and application in lumasiran clinical trials.
Valerie A Clausen, Karen H Cao, John M Gansner, Gabriel J Robbie, Jing-Tao Wu

Bioanalysis· May 2023

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Population Pharmacokinetic Analysis of the RNAi Therapeutic Givosiran in Patients with Acute Hepatic Porphyria.
Megan Melch, Jongtae Lee, Claudia Jomphe, Gabriel J Robbie

Clin Pharmacokinet· January 2023

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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of -Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human.
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Gabriel Robbie

Drug Metab Dispos· June 2022

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Correction to: Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria.
Prajakta Badri, Xuemin Jiang, Anna Borodovsky, Nader Najafan, Jae Kim, Gabriel J Robbie

Clin Pharmacokinet· June 2022

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Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection.
Sneha V Gupta, Marie C Fanget, Christopher MacLauchlin, Valerie A Clausen, Jing Li, Gabriel J Robbie

Drugs R D· December 2021

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A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver.
Daphne Vassiliou, Eliane Sardh, Pauline Harper, Amy R Simon, Valerie A Clausen, Gabriel J Robbie

Clin Pharmacol Ther· November 2021

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Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria.
Prajakta Badri, Xuemin Jiang, Anna Borodovsky, Nader Najafian, Jae Kim, Gabriel J Robbie

Clin Pharmacokinet· March 2021

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Single-Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N-acetylgalactosamine-Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects.
Bahru A Habtemariam, Verena Karsten, Husain Attarwala, Varun Goel, Megan Melch, Gabriel J Robbie

Clin Pharmacol Ther· February 2021

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Normal reference ranges for urinary δ-aminolevulinic acid and porphobilinogen levels.
Sagar Agarwal, Bahru Habtemarium, Yuanxin Xu, Amy R Simon, Jae B Kim, Gabriel J Robbie

JIMD Rep· January 2021

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Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria.
Sagar Agarwal, Amy R Simon, Varun Goel, Bahru A Habtemariam, Valerie A Clausen, Gabriel J Robbie

Clin Pharmacol Ther· July 2020

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Population Pharmacokinetic-Pharmacodynamic Model of Serum Transthyretin Following Patisiran Administration.
Varun Goel, Nathalie H Gosselin, Claudia Jomphe, Xiaoping Zhang, Jean-Francois Marier, Gabriel J Robbie

Nucleic Acid Ther· June 2020

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Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin-Mediated Amyloidosis.
Xiaoping Zhang, Varun Goel, Gabriel J Robbie

J Clin Pharmacol· May 2020

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Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure-Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin-Mediated (hATTR) Amyloidosis.
Xiaoping Zhang, Varun Goel, Husain Attarwala, Marianne T Sweetser, Valerie A Clausen, Gabriel J Robbie

J Clin Pharmacol· January 2020

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Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA.
Carrie Rocca, Sean Dennin, Yongli Gu, Joohwan Kim, Samantha Chigas, Gabriel Robbie

Bioanalysis· November 2019

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Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults.
Xiang-Qing Yu, Gabriel J Robbie, Yuling Wu, Mark T Esser, Kathryn Jensen

Antimicrob Agents Chemother· January 2017

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Targeting the interferon pathway with sifalimumab for the treatment of systemic lupus erythematosus.
Warren Greth, Gabriel J Robbie, Philip Brohawn, Micki Hultquist, Bing Yao

Immunotherapy· January 2017

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Phase 1 Dose Escalation Study of MEDI-565, a Bispecific T-Cell Engager that Targets Human Carcinoembryonic Antigen, in Patients With Advanced Gastrointestinal Adenocarcinomas.
Michael Pishvaian, Michael A Morse, Jennifer McDevitt, Jonathan D Norton, Song Ren, Gabriel J Robbie

Clin Colorectal Cancer· December 2016

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Population pharmacokinetic analysis of sifalimumab from a clinical phase IIb trial in systemic lupus erythematosus patients.
Bo Zheng, Xiang-Qing Yu, Warren Greth, Gabriel J Robbie

Br J Clin Pharmacol· May 2016

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Serum palivizumab level is associated with decreased severity of respiratory syncytial virus disease in high-risk infants.
Michael L Forbes, Veena R Kumar, Ram Yogev, Xionghua Wu, Gabriel J Robbie

Hum Vaccin Immunother· September 2015

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Randomized, Double-Blind Study of the Pharmacokinetics and Safety of Palivizumab Liquid Formulation Compared with Lyophilized Formulation.
Gabriel J Robbie, Doris Makari, Brian Harris, Genevieve A Losonsky, Hasan S Jafri

Infect Dis Ther· December 2014

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A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults.
Gabriel J Robbie, Ryan Criste, William F Dall'acqua, Kathryn Jensen, Nita K Patel

Antimicrob Agents Chemother· December 2013

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