Publications by authors named "Gary Box"

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Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer.
Maria J Ortiz-Ruiz, Olajumoke Popoola, Konstantinos Mitsopoulos, Robert Te-Poele, Rahul S Samant, Gary Box

ACS Chem Biol· July 2025

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Discovery of an Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
Alice C Harnden, Owen A Davis, Gary M Box, Angela Hayes, Louise D Johnson

J Med Chem· April 2023

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Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 .
Rosemary Huckvale, Alice C Harnden, Kwai-Ming J Cheung, Olivier A Pierrat, Rachel Talbot, Gary M Box

J Med Chem· June 2022

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FGF7-FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas.
Christopher I Milton, Joanna Selfe, Ewa Aladowicz, Stella Y K Man, Carolina Bernauer, Gary Box

Mol Oncol· March 2022

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Breast Tumour Kinase (Brk/PTK6) Contributes to Breast Tumour Xenograft Growth and Modulates Chemotherapeutic Responses In Vitro.
Rajpal S Burmi, Gary M Box, Umar Wazir, Haroon A Hussain, Julie A Davies

Genes (Basel)· February 2022

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Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma.
Evon Poon, Tong Liang, Yann Jamin, Susanne Walz, Colin Kwok, Gary Box

J Clin Invest· November 2020

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Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice.
Alexis De Haven Brandon, Gary Box, Albert Hallsworth, William Court, Nicoll Matthews

Sci Rep· July 2020

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Achieving Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
Benjamin R Bellenie, Kwai-Ming J Cheung, Ana Varela, Olivier A Pierrat, Gavin W Collie, Gary M Box

J Med Chem· April 2020

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Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736.
Andrew S Moore, Amir Faisal, Grace W Y Mak, Farideh Miraki-Moud, Vassilios Bavetsias, Gary Box

Blood Adv· April 2020

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Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice.
Nigel Bush, Andrew Healey, Anant Shah, Gary Box, Vladimir Kirkin

Front Pharmacol· February 2020

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Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice.
Nigel Bush, Andrew Healey, Anant Shah, Gary Box, Vladimir Kirkin

Front Pharmacol· November 2019

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Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Steve Wagner, Georgios Vlachogiannis, Alexis De Haven Brandon, Melanie Valenti, Gary Box

Oncogene· July 2019

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Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Steve Wagner, Georgios Vlachogiannis, Alexis De Haven Brandon, Melanie Valenti, Gary Box

Oncogene· March 2019

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Correction: Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors.
Swee Y Sharp, Kathy Boxall, Martin Rowlands, Chrisostomos Prodromou, S Mark Roe, Gary Box

Cancer Res· January 2019

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Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
Hannah L Woodward, Paolo Innocenti, Kwai-Ming J Cheung, Angela Hayes, Jennie Roberts, Gary Box

J Med Chem· September 2018

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Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma.
Lauren C J Baker, Arti Sikka, Jonathan M Price, Jessica K R Boult, Elise Y Lepicard, Gary Box, Carol Box

Front Oncol· July 2018

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Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging.
Anant Shah, Nigel Bush, Gary Box, Suzanne Eccles, Jeffrey Bamber

Photoacoustics· December 2017

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Modulation of Plasma Metabolite Biomarkers of the MAPK Pathway with MEK Inhibitor RO4987655: Pharmacodynamic and Predictive Potential in Metastatic Melanoma.
Joo Ern Ang, Akos Pal, Yasmin J Asad, Alan T Henley, Melanie Valenti, Gary Box

Mol Cancer Ther· October 2017

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Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI.
Jessica K R Boult, Gary Box, Maria Vinci, Lara Perryman, Suzanne A Eccles

Neoplasia· September 2017

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Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Amir Faisal, Grace W Y Mak, Mark D Gurden, Cristina P R Xavier, Simon J Anderhub, Gary Box

Br J Cancer· April 2017

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Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.
Paul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, Olajumoke Adeniji-Popoola, Gary Box

Elife· December 2016

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Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging.
Jessica K R Boult, Marco Borri, Alexa Jury, Sergey Popov, Gary Box

NMR Biomed· November 2016

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Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.
Joo Ern Ang, Rupinder Pandher, Joo Chew Ang, Yasmin J Asad, Alan T Henley, Gary Box

Mol Cancer Ther· June 2016

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Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
James D Osborne, Thomas P Matthews, Tatiana McHardy, Nicolas Proisy, Kwai-Ming J Cheung, Katherine J Boxall, Gary Box

J Med Chem· June 2016

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Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
Paolo Innocenti, Hannah L Woodward, Savade Solanki, Sébastien Naud, Isaac M Westwood, Gary Box

J Med Chem· April 2016

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