Publications by authors named "Gary Perdew"

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produces previously unappreciated AHR-activating metabolites and promotes CRC cell proliferation via the AHR-TERT axis.
Kyoung-Jae Won, Pei-Ru Jin, Lydia Davis, Jimmy Orjala, Abigail T Armstrong, Gary H Perdew

bioRxiv· September 2025

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The Janus-facedness of the aryl hydrocarbon receptor pathway Report of the 6th International AHR Meeting: Research, Prevention, Therapy.
Thomas Haarmann-Stemmann, Doreen Reichert, Xavier Coumoul, B Paige Lawrence, Gary H Perdew

Biochem Pharmacol· April 2025

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Glucuronidation Metabolomic Fingerprinting to Map Host-Microbe Metabolism.
Andrew Patterson, Nina Boyle, Josh John, Mingxun Wang, Helena Mannochio-Russo, Gary Perdew

Res Sq· April 2025

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Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context.
Fangcong Dong, Andrew J Annalora, Iain A Murray, Debopriya Chakraborty, Denise M Coslo, Gary H Perdew

Nutrients· February 2025

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Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation.
Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A Murray, Gary H Perdew

Adv Sci (Weinh)· October 2024

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Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice.
Yuan Tian, Bipin Rimal, Jordan E Bisanz, Wei Gui, Trenton M Wolfe, Gary H Perdew

Environ Health Perspect· August 2024

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Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress.
Mallappa Anitha, Supriya M Kumar, Imhoi Koo, Gary H Perdew, Shanthi Srinivasan

Int J Mol Sci· August 2024

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The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment.
David L Eaton, Ted W Simon, Norbert E Kaminski, Gary H Perdew, Daniel W Nebert

Regul Toxicol Pharmacol· May 2024

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Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors.
David L Eaton, Ted W Simon, Norbert E Kaminski, Gary H Perdew, Daniel W Nebert

Regul Toxicol Pharmacol· May 2024

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Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids.
Bokai Zhu, Xiaoyang Zhu, Michael G Borland, Douglas H Ralph, Christopher R Chiaro, Gary H Perdew

Biomolecules· May 2024

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Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine.
Debopriya Chakraborty, Denise M Coslo, Iain A Murray, Anitha Vijay, Andrew D Patterson, Gary H Perdew

FASEB J· February 2024

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Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation.
Kushal Saha, Ashwinkumar Subramenium Ganapathy, Alexandra Wang, Priya Arumugam, Nathan Michael Morris, Gary H Perdew

Mucosal Immunol· December 2023

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Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer.
John T Isaacs, Susan L Dalrymple, Lizamma Antony, David Marc Rosen, Ilsa M Coleman, Gary H Perdew

Prostate· November 2023

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Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites.
Dhwani Patel, Iain A Murray, Fangcong Dong, Andrew J Annalora, Krishne Gowda, Gary H Perdew

Metabolites· August 2023

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Complex chemical signals dictate Ah receptor activation through the gut-lung axis.
Fangcong Dong, Iain A Murray, Andrew Annalora, Denise M Coslo, Dhimant Desai, Gary H Perdew

FASEB J· July 2023

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Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways.
Ashwinkumar Subramenium Ganapathy, Kushal Saha, Alexandra Wang, Priya Arumugam, Viszwapriya Dharmaprakash, Gary Perdew

Cell Rep· July 2023

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Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms ().
Xiaoling Chen, Andrew D Patterson, Gary H Perdew, Iain A Murray, Joshua J Kellogg

J Funct Foods· July 2023

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Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback.
Fangcong Dong, Andrew J Annalora, Iain A Murray, Yuan Tian, Craig B Marcus, Gary H Perdew

Int J Tryptophan Res· July 2023

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Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation.
Ethan W Morgan, Fangcong Dong, Andrew J Annalora, Iain A Murray, Trenton Wolfe, Gary H Perdew

Int J Tryptophan Res· July 2023

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Complex chemical signals dictate Ah receptor activation through the gut-lung axis.
Fangcong Dong, Iain A Murray, Andrew Annalora, Denise Coslo, Dhimant Desai, Gary H Perdew

bioRxiv· April 2023

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Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice.
Anitha Vijay, Nina R Boyle, Supriya M Kumar, Gary H Perdew, Shanthi Srinivasan

Toxicol Sci· March 2023

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The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022.
Gary H Perdew, Charlotte Esser, Megan Snyder, David H Sherr, Ellen H van den Bogaard

Int J Mol Sci· March 2023

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Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders.
Gijs Rikken, Kayla J Smith, Noa J M van den Brink, Jos P H Smits, Krishne Gowda, Gary H Perdew

Biochem Pharmacol· February 2023

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Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming.
Xiaoliang Zhou, Debopriya Chakraborty, Iain A Murray, Denise Coslo, Zoe Kehs, Gary H Perdew

Lab Invest· February 2023

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Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation.
Ethan W Morgan, Fangcong Dong, Andrew Annalora, Iain A Murray, Trenton Wolfe, Gary H Perdew

bioRxiv· January 2023

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