Publications by authors named "Gaspar Kitange"

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XPO1-inhibitor Selinexor induces MGMT expression by activating PKA-CREB signaling in wildtype glioblastoma.
Josephine A Mapunda, Yuta Suzuki, Danielle Burgenske, Paul A Decker, Lin Zhang, Gaspar J Kitange

Front Oncol· October 2025

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PKMζ, a Brain-specific PKCζ Isoform, is Required for Glycolysis and Myofibroblastic Activation of Hepatic Stellate Cells.
Xianghu Wang, Yuanguo Wang, Bing Bai, Aurpita Shaha, Wenming Bao, Gaspar J Kitange

Cell Mol Gastroenterol Hepatol· April 2025

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Establishment of a brain tumor consortium of Africa: Advancing collaborative research and advocacy for brain tumors in Africa.
Lateef A Odukoya, Kwadwo Darko, Francis Zerd, Nathalie C Ghomsi, Gloria Kabare, Gaspar J Kitange

Neurooncol Adv· November 2024

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RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.
Ann C Mladek, Huihuang Yan, Shulan Tian, Paul A Decker, Danielle M Burgenske, Gaspar J Kitange

Neuro Oncol· August 2022

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Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.
Kendra A Porath, Michael S Regan, Jessica I Griffith, Sonia Jain, Sylwia A Stopka, Gaspar J Kitange

Neurooncol Adv· August 2022

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Detection of temozolomide-induced hypermutation and response to PD-1 checkpoint inhibitor in recurrent glioblastoma.
Paul Daniel, Brian Meehan, Siham Sabri, Fatemeh Jamali, Jann N Sarkaria, Gaspar Kitange

Neurooncol Adv· May 2022

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Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.
Danielle M Burgenske, Surabhi Talele, Jenny L Pokorny, Ann C Mladek, Katrina K Bakken, Gaspar J Kitange

Neuro Oncol· March 2022

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Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma.
Bianca-Maria Marin, Kendra A Porath, Sonia Jain, Minjee Kim, Jason E Conage-Pough, Gaspar J Kitange

Neuro Oncol· December 2021

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Experimental design of preclinical experiments: number of PDX lines vs subsampling within PDX lines.
Jeanette E Eckel-Passow, Gaspar J Kitange, Paul A Decker, Matthew L Kosel, Danielle M Burgenske

Neuro Oncol· December 2021

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Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma.
Rachael A Vaubel, Shulan Tian, Dioval Remonde, Mark A Schroeder, Ann C Mladek, Gaspar J Kitange

Clin Cancer Res· March 2020

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Molecular profiling of long-term IDH-wildtype glioblastoma survivors.
Danielle M Burgenske, Jie Yang, Paul A Decker, Thomas M Kollmeyer, Matthew L Kosel, Gaspar J Kitange

Neuro Oncol· November 2019

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Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells.
Bryan G Harder, Sen Peng, Christopher P Sereduk, Andrej M Sodoma, Gaspar J Kitange

Mol Med· November 2019

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Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.
Zachary D Nagel, Andrew A Beharry, Patrizia Mazzucato, Gaspar J Kitange, Jann N Sarkaria

PLoS One· October 2019

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PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity.
Shiv K Gupta, Emily J Smith, Ann C Mladek, Shulan Tian, Paul A Decker, Gaspar J Kitange

Front Oncol· January 2019

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Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood-Brain Barrier.
Minjee Kim, Daniel J Ma, David Calligaris, Shuangling Zhang, Ryan W Feathers, Gaspar J Kitange

Mol Cancer Ther· September 2018

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A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma.
Xiaoyue Chen, Minjie Zhang, Haiyun Gan, Heping Wang, Jeong-Heon Lee, Gaspar J Kitange

Nat Commun· July 2018

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Restricted Delivery of Talazoparib Across the Blood-Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma.
Sani H Kizilbash, Shiv K Gupta, Kenneth Chang, Ryo Kawashima, Karen E Parrish, Gaspar J Kitange

Mol Cancer Ther· December 2017

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Real-Time Methylation-Specific Polymerase Chain Reaction for MGMT Promoter Methylation Clinical Testing in Glioblastoma: An Alternative Detection Method for a Heterogeneous Process.
Cristiane M Ida, Malinda L Butz, Robert B Jenkins, Jann N Sarkaria, Gaspar J Kitange

Am J Clin Pathol· October 2017

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DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.
Zachary D Nagel, Gaspar J Kitange, Shiv K Gupta, Brian A Joughin, Isaac A Chaim

Cancer Res· January 2017

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Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma.
Shiv K Gupta, Sani H Kizilbash, Brett L Carlson, Ann C Mladek, Felix Boakye-Agyeman, Gaspar J Kitange

J Natl Cancer Inst· May 2016

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Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins.
Gaspar J Kitange, Ann C Mladek, Mark A Schroeder, Jenny C Pokorny, Brett L Carlson

Cell Rep· March 2016

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Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models.
Ling Cen, Brett L Carlson, Jenny L Pokorny, Ann C Mladek, Patrick T Grogan, Gaspar J Kitange

Neuro Oncol· June 2013

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Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex.
Hacer Guvenc, Marat S Pavlyukov, Kaushal Joshi, Habibe Kurt, Yeshavanth K Banasavadi-Siddegowda, Gaspar Kitange

Clin Cancer Res· February 2013

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The role of LAT1 in (18)F-DOPA uptake in malignant gliomas.
Ryan S Youland, Gaspar J Kitange, Timothy E Peterson, Deanna H Pafundi, Judi A Ramiscal

J Neurooncol· January 2013

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p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells.
Ling Cen, Brett L Carlson, Mark A Schroeder, Jamie L Ostrem, Gaspar J Kitange

Neuro Oncol· July 2012

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