Publications by authors named "Gemma Arsequell"

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Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer's Disease.
Sameer M Joshi, Thomas C Wilson, Zibo Li, Sean Preshlock, Vanessa Gómez-Vallejo, Gemma Arsequell

Molecules· January 2024

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Binding of common organic UV-filters to the thyroid hormone transport protein transthyretin using in vitro and in silico studies: Potential implications in health.
Ellen Y Cotrina, Ângela Oliveira, Jordi Llop, Jordi Quintana, Xevi Biarnés, Gemma Arsequell

Environ Res· January 2023

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Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography.
Luka Rejc, Vanessa Gómez-Vallejo, Ana Joya, Gemma Arsequell, Ander Egimendia

Alzheimers Res Ther· June 2022

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Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease.
Ellen Y Cotrina, Luis Miguel Santos, Josep Rivas, Daniel Blasi, José Pedro Leite, Gemma Arsequell

Eur J Med Chem· December 2021

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Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-β Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study1.
Luka Rejc, Vanessa Gómez-Vallejo, Xabier Rios, Unai Cossío, Zuriñe Baz, Gemma Arsequell

J Alzheimers Dis· September 2021

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Neuroprotection in early stages of Alzheimer's disease is promoted by transthyretin angiogenic properties.
Tiago Gião, Joana Saavedra, José Ricardo Vieira, Marta Teixeira Pinto, Gemma Arsequell

Alzheimers Res Ther· August 2021

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Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?
Alex Olvera, Samandhy Cedeño, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell

Front Immunol· June 2021

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An Assay for Screening Potential Drug Candidates for Alzheimer's Disease That Act as Chaperones of the Transthyretin and Amyloid-β Peptides Interaction.
Ellen Y Cotrina, Ana Gimeno, Jordi Llop, Jesús Jiménez-Barbero, Jordi Quintana, Gemma Arsequell

Chemistry· December 2020

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Optimization of kinetic stabilizers of tetrameric transthyretin: A prospective ligand efficiency-guided approach.
Ellen Y Cotrina, Daniel Blasi, Marta Vilà, Antoni Planas, Cele Abad-Zapatero, Gemma Arsequell

Bioorg Med Chem· December 2020

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Preparative Scale Production of Recombinant Human Transthyretin for Biophysical Studies of Protein-Ligand and Protein-Protein Interactions.
Ellen Y Cotrina, Marta Vilà, Joan Nieto, Gemma Arsequell, Antoni Planas

Int J Mol Sci· December 2020

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Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer.
Ellen Y Cotrina, Ângela Oliveira, José Pedro Leite, Jordi Llop, Luis Gales, Gemma Arsequell

Int J Mol Sci· September 2020

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Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery.
Ellen Y Cotrina, Ana Gimeno, Jordi Llop, Jesús Jiménez-Barbero, Jordi Quintana, Gemma Arsequell

J Med Chem· March 2020

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Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease.
Tiago Gião, Joana Saavedra, Ellen Cotrina, Jordi Quintana, Jordi Llop, Gemma Arsequell

Int J Mol Sci· March 2020

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Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD.
Xabier Rios, Vanessa Gómez-Vallejo, Abraham Martín, Unai Cossío, Miguel Ángel Morcillo, Gemma Arsequell

Sci Rep· September 2019

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Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy .
Alex Olvera, Javier P Martinez, Maria Casadellà, Anuska Llano, Míriam Rosás, Gemma Arsequell

Front Immunol· January 2018

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Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal.
Ana Gimeno, Luis M Santos, Mobina Alemi, Josep Rivas, Daniel Blasi, Gemma Arsequell

J Med Chem· July 2017

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Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.
Mònica Rosa, Verónica Gonzalez-Nunez, Katherine Barreto-Valer, Filipa Marcelo, Julia Sánchez-Sánchez, Gemma Arsequell

Bioorg Med Chem· April 2017

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Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.
Mònica Rosa, Filipa Marcelo, Luis P Calle, Catherine Rougeot, Jesús Jiménez-Barbero, Gemma Arsequell

Bioorg Med Chem Lett· November 2015

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Optimized Proteomic Mass Spectrometry Characterization of Recombinant Human μ-Opioid Receptor Functionally Expressed in Pichia pastoris Cell Lines.
Mònica Rosa, Joan Josep Bech-Serra, Francesc Canals, Jean Marie Zajac, Franck Talmont, Gemma Arsequell

J Proteome Res· August 2015

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Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms.
Mònica Rosa, Gianluigi Caltabiano, Katy Barreto-Valer, Verónica Gonzalez-Nunez, José C Gómez-Tamayo, Gemma Arsequell

ACS Med Chem Lett· August 2015

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Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions.
Maria Vilaró, Joan Nieto, Juan Ramón La Parra, Maria Rosário Almeida, Alfredo Ballesteros, Gemma Arsequell

ACS Comb Sci· January 2015

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Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model.
Carlos A Ribeiro, Sandra Marisa Oliveira, Luis F Guido, Ana Magalhães, Gregorio Valencia, Gemma Arsequell

J Alzheimers Dis· October 2014

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Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation.
Ellen Y Cotrina, Marta Pinto, Lluís Bosch, Marta Vilà, Daniel Blasi, Gemma Arsequell

J Med Chem· November 2013

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Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.
Mònica Rosa, Gemma Arsequell, Catherine Rougeot, Luis P Calle, Filipa Marcelo

J Med Chem· February 2012

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Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.
Marta Pinto, Catherine Rougeot, Luis Gracia, Mònica Rosa, Andrés García, Gemma Arsequell

ACS Med Chem Lett· January 2012

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