Publications by authors named "Gregorio Valencia"

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Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery.
Ellen Y Cotrina, Ana Gimeno, Jordi Llop, Jesús Jiménez-Barbero, Jordi Quintana, Gregorio Valencia

J Med Chem· March 2020

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Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD.
Xabier Rios, Vanessa Gómez-Vallejo, Abraham Martín, Unai Cossío, Miguel Ángel Morcillo, Gregorio Valencia

Sci Rep· September 2019

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Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy .
Alex Olvera, Javier P Martinez, Maria Casadellà, Anuska Llano, Míriam Rosás, Gregorio Valencia

Front Immunol· January 2018

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Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal.
Ana Gimeno, Luis M Santos, Mobina Alemi, Josep Rivas, Daniel Blasi, Gregorio Valencia

J Med Chem· July 2017

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Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.
Mònica Rosa, Verónica Gonzalez-Nunez, Katherine Barreto-Valer, Filipa Marcelo, Julia Sánchez-Sánchez, Gregorio Valencia

Bioorg Med Chem· April 2017

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Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.
Mònica Rosa, Filipa Marcelo, Luis P Calle, Catherine Rougeot, Jesús Jiménez-Barbero, Gregorio Valencia

Bioorg Med Chem Lett· November 2015

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Optimized Proteomic Mass Spectrometry Characterization of Recombinant Human μ-Opioid Receptor Functionally Expressed in Pichia pastoris Cell Lines.
Mònica Rosa, Joan Josep Bech-Serra, Francesc Canals, Jean Marie Zajac, Franck Talmont, Gregorio Valencia

J Proteome Res· August 2015

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Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms.
Mònica Rosa, Gianluigi Caltabiano, Katy Barreto-Valer, Verónica Gonzalez-Nunez, José C Gómez-Tamayo, Gregorio Valencia

ACS Med Chem Lett· August 2015

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Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions.
Maria Vilaró, Joan Nieto, Juan Ramón La Parra, Maria Rosário Almeida, Alfredo Ballesteros, Gregorio Valencia

ACS Comb Sci· January 2015

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Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model.
Carlos A Ribeiro, Sandra Marisa Oliveira, Luis F Guido, Ana Magalhães, Gregorio Valencia

J Alzheimers Dis· October 2014

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Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation.
Ellen Y Cotrina, Marta Pinto, Lluís Bosch, Marta Vilà, Daniel Blasi, Gregorio Valencia

J Med Chem· November 2013

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Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.
Mònica Rosa, Gemma Arsequell, Catherine Rougeot, Luis P Calle, Filipa Marcelo, Gregorio Valencia

J Med Chem· February 2012

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Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.
Marta Pinto, Catherine Rougeot, Luis Gracia, Mònica Rosa, Andrés García, Gregorio Valencia

ACS Med Chem Lett· January 2012

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Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.
Gemma Arsequell, Mònica Rosa, Carlos Mayato, Rosa L Dorta, Verónica Gonzalez-Nunez, Gregorio Valencia

Org Biomol Chem· September 2011

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Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
Asensio González, Josefina Quirante, Joan Nieto, Maria Rosário Almeida, Maria Joao Saraiva, Gregorio Valencia

Bioorg Med Chem Lett· September 2009

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Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive.
Gemma Arsequell, Mariona Salvatella, Gregorio Valencia, Alfonso Fernández-Mayoralas, Marco Fontanella

J Med Chem· May 2009

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Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Teresa Mairal, Joan Nieto, Marta Pinto, Maria Rosário Almeida, Luis Gales, Gregorio Valencia

PLoS One· February 2009

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Arylation of Phe and Tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water.
Maria Vilaró, Gemma Arsequell, Gregorio Valencia, Alfredo Ballesteros, José Barluenga

Org Lett· August 2008

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Iodination of salicylic acid improves its binding to transthyretin.
Luís Gales, Maria Rosário Almeida, Gemma Arsequell, Gregorio Valencia, Maria João Saraiva

Biochim Biophys Acta· March 2008

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Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design.
Isabel Cardoso, Maria Rosário Almeida, Nelson Ferreira, Gemma Arsequell, Gregorio Valencia

Biochem J· November 2007

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Iodination of proteins by IPy2BF4, a new tool in protein chemistry.
Gemma Espuña, David Andreu, José Barluenga, Xavier Pérez, Antoni Planas, Gregorio Valencia

Biochemistry· May 2006

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Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.
Luís Gales, Sandra Macedo-Ribeiro, Gemma Arsequell, Gregorio Valencia, Maria João Saraiva

Biochem J· June 2005

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Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative.
Maria Rosário Almeida, Bárbara Macedo, Isabel Cardoso, Isabel Alves, Gregorio Valencia

Biochem J· July 2004

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A highly toxic morphine-3-glucuronide derivative.
Mariona Salvatella, Gemma Arsequell, Gregorio Valencia, Raquel E Rodríguez

Bioorg Med Chem Lett· February 2004

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Regioselective postsynthetic modification of phenylalanine side chains of peptides leading to uncommon ortho-iodinated analogues.
Gemma Espuña, Gemma Arsequell, Gregorio Valencia, José Barluenga, Julia M Alvarez-Gutiérrez

Angew Chem Int Ed Engl· January 2004

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