Publications by authors named "Geoff Otto"

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Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab.
David R Gandara, Sarah M Paul, Marcin Kowanetz, Erica Schleifman, Wei Zou, Yan Li, Achim Rittmeyer, Louis Fehrenbacher, Geoff Otto, Christine Malboeuf

September 2018

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Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.
Travis A Clark, Jon H Chung, Mark Kennedy, Jason D Hughes, Niru Chennagiri, Geoff A Otto

J Mol Diagn· September 2018

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Distinct age-associated molecular profiles in acute myeloid leukemia defined by comprehensive clinical genomic profiling.
Katherine Tarlock, Shan Zhong, Yuting He, Rhonda Ries, Eric Severson, Geoff A Otto

Oncotarget· May 2018

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Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer.
Heather A Parsons, Julia A Beaver, Ashley Cimino-Mathews, Siraj M Ali, Jennifer Axilbund, Geoff A Otto

Clin Cancer Res· January 2017

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Next-Generation Sequencing Reveals Pathway Activations and New Routes to Targeted Therapies in Cutaneous Metastatic Melanoma.
J Andrew Carlson, Jose Candido Caldeira Xavier, Ashley Tarasen, Christine E Sheehan, Geoff Otto

Am J Dermatopathol· January 2017

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Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting.
Jie He, Omar Abdel-Wahab, Michelle K Nahas, Kai Wang, Raajit K Rampal, Geoff A Otto

Blood· June 2016

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RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors.
Haiying Cheng, Yiyu Zou, Jeffrey S Ross, Kai Wang, Xuewen Liu, Geoff Otto

Cancer Discov· December 2015

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Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.
Thomas Wiesner, Jie He, Roman Yelensky, Rosaura Esteve-Puig, Thomas Botton, Geoff Otto

Nat Commun· October 2015

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Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options.
Jeffrey S Ross, Sunil Badve, Kai Wang, Christine E Sheehan, Ann B Boguniewicz, Geoff A Otto

Arch Pathol Lab Med· May 2015

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Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site: New Routes to Targeted Therapies.
Jeffrey S Ross, Kai Wang, Laurie Gay, Geoff A Otto, Emily White

JAMA Oncol· April 2015

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Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.
Raajit Rampal, Jihae Ahn, Omar Abdel-Wahab, Michelle Nahas, Kai Wang, Geoff A Otto

Proc Natl Acad Sci U S A· December 2014

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Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions.
Christine M Lovly, Abha Gupta, Doron Lipson, Geoff Otto, Tina Brennan

Cancer Discov· August 2014

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Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer.
Rinath Jeselsohn, Roman Yelensky, Gilles Buchwalter, Garrett Frampton, Funda Meric-Bernstam, Geoff Otto

Clin Cancer Res· April 2014

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New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.
Jeffrey S Ross, Kai Wang, Laurie Gay, Rami Al-Rohil, Janne V Rand, Geoff A Otto

Oncologist· March 2014

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Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy.
Jeffrey S Ross, Kai Wang, Rami N Al-Rohil, Tipu Nazeer, Christine E Sheehan, Geoff A Otto

Mod Pathol· February 2014

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Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.
Jeffrey S Ross, Kai Wang, Janna V Rand, Christine E Sheehan, Timothy A Jennings, Geoff A Otto

Am J Surg Pathol· February 2014

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A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.
Jeffrey S Ross, Kai Wang, Laurie M Gay, Rami N Al-Rohil, Tipu Nazeer, Geoff A Otto

Clin Cancer Res· January 2014

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Clinical next-generation sequencing successfully applied to fine-needle aspirations of pulmonary and pancreatic neoplasms.
Geneva Young, Kai Wang, Jie He, Geoff Otto, Matthew Hawryluk

Cancer Cytopathol· December 2013

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BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition.
Katherine E Hutchinson, Doron Lipson, Philip J Stephens, Geoff Otto, Brian D Lehmann

Clin Cancer Res· December 2013

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Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing.
Garrett M Frampton, Alex Fichtenholtz, Geoff A Otto, Kai Wang, Sean R Downing

Nat Biotechnol· November 2013

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Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations.
Jeffrey S Ross, Kai Wang, Christine E Sheehan, Ann B Boguniewicz, Geoff Otto

Clin Cancer Res· May 2013

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Next-generation sequencing identifies and immunohistochemistry confirms a novel crizotinib-sensitive ALK rearrangement in a patient with metastatic non-small-cell lung cancer.
Nir Peled, Gary Palmer, Fred R Hirsch, Murry W Wynes, Maya Ilouze, Geoff A Otto

J Thorac Oncol· September 2012

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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.
Doron Lipson, Marzia Capelletti, Roman Yelensky, Geoff Otto, Alex Parker

Nat Med· February 2012

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Real-time DNA sequencing from single polymerase molecules.
John Eid, Adrian Fehr, Jeremy Gray, Khai Luong, John Lyle, Geoff Otto

Science· January 2009

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Long, processive enzymatic DNA synthesis using 100% dye-labeled terminal phosphate-linked nucleotides.
Jonas Korlach, Arek Bibillo, Jeffrey Wegener, Paul Peluso, Thang T Pham, Geoff A Otto

Nucleosides Nucleotides Nucleic Acids· September 2008

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