Publications by authors named "Georg Fey"

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Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells.
Todd A Braciak, Claudia C Roskopf, Sarah Wildenhain, Nadja C Fenn, Christian B Schiller, Georg H Fey

Oncoimmunology· July 2018

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CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells.
Christian B Schiller, Todd A Braciak, Nadja C Fenn, Ursula J E Seidel, Claudia C Roskopf, Georg H Fey

Oncotarget· December 2016

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A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein.
Manal Amoury, Radoslav Mladenov, Thomas Nachreiner, Anh-Tuan Pham, Dmitrij Hristodorov, Georg Fey

Int J Cancer· August 2016

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Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.
Elisavet I Chatzopoulou, Claudia C Roskopf, Farzad Sekhavati, Todd A Braciak, Nadja C Fenn, Georg H Fey

Analyst· April 2016

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Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.
Claudia C Roskopf, Todd A Braciak, Nadja C Fenn, Sebastian Kobold, Georg H Fey

Oncotarget· April 2016

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Stability and activity of MCSP-specific chimeric antigen receptors (CARs) depend on the scFv antigen-binding domain and the protein backbone.
Christian Krug, Katrin Birkholz, Alexander Paulus, Michael Schwenkert, Patrick Schmidt, Georg Fey

Cancer Immunol Immunother· December 2015

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Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia.
Carol O'Hear, Joshua F Heiber, Ingo Schubert, Georg Fey, Terrence L Geiger

Haematologica· March 2015

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A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.
Ingo Schubert, Domenica Saul, Stefanie Nowecki, Andreas Mackensen, Georg H Fey

MAbs· October 2014

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A CSPG4-specific immunotoxin kills rhabdomyosarcoma cells and binds to primary tumor tissues.
Hannes Brehm, Judith Niesen, Radoslav Mladenov, Christoph Stein, Alessa Pardo, Georg Fey

Cancer Lett· October 2014

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T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.
Claudia C Roskopf, Christian B Schiller, Todd A Braciak, Sebastian Kobold, Ingo A Schubert, Georg H Fey

Oncotarget· August 2014

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NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.
Todd A Braciak, Sarah Wildenhain, Claudia C Roskopf, Ingo A Schubert, Georg H Fey

J Transl Med· November 2013

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A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by dual-targeting.
Ingo Schubert, Christian Kellner, Christoph Stein, Markus Kügler, Michael Schwenkert, Georg H Fey

MAbs· June 2012

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Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC.
Roland Repp, Christian Kellner, Anja Muskulus, Matthias Staudinger, Sahar Mohseni Nodehi, Georg H Fey

J Immunol Methods· October 2011

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A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting.
Ingo Schubert, Christian Kellner, Christoph Stein, Markus Kügler, Michael Schwenkert, Georg H Fey

MAbs· July 2011

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Heterodimeric bispecific antibody-derivatives against CD19 and CD16 induce effective antibody-dependent cellular cytotoxicity against B-lymphoid tumor cells.
Christian Kellner, Joerg Bruenke, Heike Horner, Joerg Schubert, Michael Schwenkert, Georg H Fey

Cancer Lett· April 2011

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Effective elimination of acute myeloid leukemic cells by recombinant bispecific antibody derivatives directed against CD33 and CD16.
Heiko Singer, Christian Kellner, Harald Lanig, Michael Aigner, Bernhard Stockmeyer, Georg H Fey

J Immunother· December 2010

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Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo.
Marco de Bruyn, Anna A Rybczynska, Yunwei Wei, Michael Schwenkert, Georg H Fey

Mol Cancer· November 2010

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Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation.
Katrin Birkholz, Michael Schwenkert, Christian Kellner, Stefanie Gross, Georg Fey

Blood· September 2010

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A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting.
Markus Kügler, Christoph Stein, Christian Kellner, Kristin Mentz, Domenica Saul, Georg H Fey

Br J Haematol· September 2010

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Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems.
Miriam Rothdiener, Dafne Müller, Patricia Garrido Castro, Anja Scholz, Michael Schwemmlein, Georg Fey

J Control Release· June 2010

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Novel conjugates of single-chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells.
Christoph Stein, Christian Kellner, Markus Kügler, Nina Reiff, Kristin Mentz, Georg H Fey

Br J Haematol· March 2010

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A recombinant bispecific single-chain fragment variable specific for HLA class II and Fc alpha RI (CD89) recruits polymorphonuclear neutrophils for efficient lysis of malignant B lymphoid cells.
Yvonne Guettinger, Karin Barbin, Matthias Peipp, Joerg Bruenke, Michael Dechant, Georg H Fey

J Immunol· February 2010

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A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells.
Christian Kellner, Joerg Bruenke, Julia Stieglmaier, Michael Schwemmlein, Michael Schwenkert, Georg H Fey

J Immunother· July 2009

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Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework.
Markus Kügler, Christoph Stein, Michael Schwenkert, Domenica Saul, Lena Vockentanz, Georg H Fey

Protein Eng Des Sel· March 2009

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T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Priti Kumar, Hong-Seok Ban, Sang-Soo Kim, Haoquan Wu, Todd Pearson, Georg H Fey

Cell· August 2008

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