Publications by authors named "Judith Niesen"

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Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.
Melanie Schoof, Tuyu Zheng, Martin Sill, Roland Imle, Alessia Cais, Judith Niesen

Nat Genet· December 2025

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Epidermal growth factor receptor specific immunotherapy for SHH medulloblastoma tested in an in vitro blood-brain barrier-model.
Christina Krüger, Petros Paplomatas, Naomé Kreuter, Malte Hellwig, Alicia Eckhardt, Judith Niesen

Cancer Treat Res Commun· September 2025

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-mediated overexpression leads to early death and severe cerebellar malformations with rare tumor formation.
Judith Niesen, Irm Hermans-Borgmeyer, Christina Krüger, Melanie Schoof, Franziska Modemann

iScience· September 2023

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DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles.
Sepehr Safaei, Malte Mohme, Judith Niesen, Ulrich Schüller, Michael Bockmayr

Oncoimmunology· August 2021

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Using the SNAP-Tag technology to easily measure and demonstrate apoptotic changes in cancer and blood cells with different dyes.
Mira Woitok, Elena Grieger, Olusiji A Akinrinmade, Susanne Bethke, Anh Tuan Pham, Judith Niesen

PLoS One· January 2021

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The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation.
Melanie Schoof, Malte Hellwig, Luke Harrison, Dörthe Holdhof, Marlen C Lauffer, Judith Niesen

Eur J Neurosci· June 2020

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Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model.
Judith Niesen, Jasmin Ohli, Jan Sedlacik, Lasse Dührsen, Malte Hellwig

Cancer Lett· May 2020

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hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures.
Dörthe Holdhof, Melanie Schoof, Malte Hellwig, Niels Hendrik Holdhof, Judith Niesen

Cereb Cortex· March 2020

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The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration.
Melanie Schoof, Michael Launspach, Dörthe Holdhof, Lynhda Nguyen, Verena Engel, Judith Niesen

Acta Neuropathol Commun· December 2019

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TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
Malte Hellwig, Marlen C Lauffer, Michael Bockmayr, Michael Spohn, Daniel J Merk, Judith Niesen

Acta Neuropathol· April 2019

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Elimination of different leukaemia subtypes using novel CD89-specific human cytolytic fusion proteins.
Gerrit Gresch, Lea Schenke, Radoslav Mladenov, Stefan Zwirner, Christian Cremer, Judith Niesen

Br J Haematol· October 2018

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Correction to: DNA methylation-based reclassification of olfactory neuroblastoma.
David Capper, Nils W Engel, Damian Stichel, Matt Lechner, Stefanie Glöss, Judith Niesen

Acta Neuropathol· September 2018

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DNA methylation-based reclassification of olfactory neuroblastoma.
David Capper, Nils W Engel, Damian Stichel, Matt Lechner, Stefanie Glöss, Judith Niesen

Acta Neuropathol· August 2018

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Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13-ETA' and the bispecific scFv [13xds16].
Elena Grieger, Gerrit Gresch, Judith Niesen, Mira Woitok, Stefan Barth

J Cancer Res Clin Oncol· November 2017

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Generation of an artificial human B cell line test system using Transpo-mAbTM technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins.
Diana Klose, Mira Woitok, Judith Niesen, Roger R Beerli, Ulf Grawunder

PLoS One· September 2017

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Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells.
Mira Woitok, Diana Klose, Stefano Di Fiore, Wolfgang Richter, Christoph Stein, Judith Niesen

Onco Targets Ther· July 2017

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The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F.
Mira Woitok, Diana Klose, Judith Niesen, Wolfgang Richter, Muhammad Abbas

Cancer Lett· October 2016

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SNAP-Tag Technology: A Useful Tool To Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments.
Judith Niesen, Markus Sack, Melanie Seidel, Rolf Fendel, Stefan Barth

Bioconjug Chem· August 2016

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A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor.
Judith Niesen, Grit Hehmann-Titt, Mira Woitok, Rolf Fendel, Stefan Barth

Cancer Lett· May 2016

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Novel EGFR-specific immunotoxins based on panitumumab and cetuximab show in vitro and ex vivo activity against different tumor entities.
Judith Niesen, Christoph Stein, Hannes Brehm, Grit Hehmann-Titt, Rolf Fendel

J Cancer Res Clin Oncol· December 2015

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The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia.
Radoslav Mladenov, Dmitrij Hristodorov, Christian Cremer, Lea Hein, Fabian Kreutzer, Judith Niesen

Int J Cancer· December 2015

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Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein.
Hannes Brehm, Dmitrij Hristodorov, Alessa Pardo, Radoslav Mladenov, Judith Niesen

Cancer Lett· September 2015

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In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells.
Judith Niesen, Hannes Brehm, Christoph Stein, Nina Berges, Alessa Pardo

J Cancer Res Clin Oncol· June 2015

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A CSPG4-specific immunotoxin kills rhabdomyosarcoma cells and binds to primary tumor tissues.
Hannes Brehm, Judith Niesen, Radoslav Mladenov, Christoph Stein, Alessa Pardo

Cancer Lett· October 2014

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EpCAM-selective elimination of carcinoma cells by a novel MAP-based cytolytic fusion protein.
Dmitrij Hristodorov, Manal Amoury, Radoslav Mladenov, Judith Niesen, Katharina Arens

Mol Cancer Ther· September 2014

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