Publications by authors named "George Koob"

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A conceptual framework for the intersection of hyperalgesia and hyperkatifeia in alcohol addiction.
George F Koob, Leandro F Vendruscolo

Alcohol· December 2025

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Why Opioids Stop Working for Pain: No Free Ride in the Brain.
Jane C Ballantyne, George F Koob

Ann Intern Med· December 2025

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Hypocretin signaling in the central amygdala drives methamphetamine self-administration in male rats.
Tyler A Zarin, Adam J Brandner, Yanan Zhang, George F Koob, Brooke E Schmeichel

Neuropharmacology· November 2025

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Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit/Stress Surfeit Disorder.
George F Koob, Leandro Vendruscolo

Curr Top Behav Neurosci· October 2025

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Neuronal Colocalization of μ-Opioid Receptor, κ-Opioid Receptor, and Oxytocin Receptor mRNA in the Central Nucleus of the Amygdala in Male and Female Mice.
Khalin E Nisbett, George F Koob

eNeuro· September 2025

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Glucagon-like peptide-1 receptor agonists, but not dipeptidyl peptidase-4 inhibitors, reduce alcohol intake.
Mehdi Farokhnia, John Tazare, Claire L Pince, Nicolaus Bruns, Joshua C Gray, George F Koob

J Clin Invest· May 2025

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Evidence for independent actions of the CRF and ghrelin systems in binge-like alcohol drinking in mice.
Rani S Richardson, Lindsay A Kryszak, Janaina C M Vendruscolo, George F Koob, Lorenzo Leggio

Prog Neuropsychopharmacol Biol Psychiatry· April 2025

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GHSR blockade, but not reduction of peripherally circulating ghrelin via β-adrenergic receptor antagonism, decreases binge-like alcohol drinking in mice.
Rani S Richardson, Lindsay A Kryszak, Janaina C M Vendruscolo, George F Koob, Leandro F Vendruscolo

Mol Psychiatry· March 2025

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The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction.
Renata C N Marchette, Leandro F Vendruscolo, George F Koob

Curr Addict Rep· February 2025

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Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial).
Mette Kruse Klausen, Tugba Kuzey, Julie Niemann Pedersen, Signe Keller Justesen, Line Rasmussen, George Koob

BMJ Open· January 2025

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PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity.
Shiyu Tang, Sung Won Kim, Amanda Olsen-Dufour, Torben Pearson, Michael Freaney, George F Koob

Neuropsychopharmacology· December 2024

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The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats.
Leandro F Vendruscolo, Janaina C M Vendruscolo, Kimberly E Whiting, Jane B Acri, Nora D Volkow, George F Koob

Psychopharmacology (Berl)· November 2024

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The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development.
Nora D Volkow, Joshua A Gordon, Diana W Bianchi, Michael F Chiang, Janine A Clayton, George F Koob

Dev Cogn Neurosci· October 2024

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George Robert Siggins: Researcher, musician, surfer, mentor, and friend.
Marisa Roberto, Michal Bajo, Paul Schweitzer, Scott D Moore, Christopher S Oleata, George F Koob

Alcohol Clin Exp Res (Hoboken)· September 2024

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PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury.
Josephin Wagner, Lauren M Park, Partha Mukhopadhyay, Csaba Matyas, Eszter Trojnar, George F Koob

Brain Behav Immun· July 2024

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Factors underlying the neurofunctional domains of the Addictions Neuroclinical Assessment assessed by a standardized neurocognitive battery.
Tommy Gunawan, Jeremy W Luk, Melanie L Schwandt, Laura E Kwako, Tonette Vinson, George F Koob

Transl Psychiatry· July 2024

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Indulging Curiosity: Preliminary Evidence of an Anxiolytic-like Effect of Castor Oil and Ricinoleic Acid.
Khalin E Nisbett, Leandro F Vendruscolo, George F Koob

Nutrients· May 2024

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Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.
András H Lékó, Adriana Gregory-Flores, Renata C N Marchette, Juan L Gomez, Janaina C M Vendruscolo, George F Koob

Commun Biol· May 2024

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Cold nociception as a measure of hyperalgesia during spontaneous heroin withdrawal in mice.
Lyndsay E Hastings, Emma V Frye, Erika R Carlson, Vicky Chuong, Aniah N Matthews, George F Koob

Pharmacol Biochem Behav· February 2024

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The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research.
Diana W Bianchi, Patricia Flatley Brennan, Michael F Chiang, Lindsey A Criswell, Rena N D'Souza, George F Koob

Nat Med· February 2024

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µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice.
Khalin E Nisbett, Leandro F Vendruscolo, George F Koob

Transl Psychiatry· February 2024

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Alcohol Use Disorder Treatment: Problems and Solutions.
George F Koob

Annu Rev Pharmacol Toxicol· January 2024

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Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice.
Rani S Richardson, Agnieszka Sulima, Kenner C Rice, Jed A Kucharczk, Kim D Janda, George F Koob

Neuropharmacology· November 2023

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Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.
Lorenzo Leggio, Andras Leko, Adriana Gregory-Flores, Renata Marchette, Juan Gomez, George Koob

Res Sq· October 2023

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Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice.
Khalin E Nisbett, Luis A Gonzalez, Marina Teruel, C Sue Carter, Leandro F Vendruscolo, George F Koob

Neurobiol Stress· September 2023

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