Publications by authors named "George Pitoc"

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An Aptamer-Based EXACT Anticoagulant as a Sustainable, Animal-Free Alternative to Unfractionated Heparin.
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen

Adv Sci (Weinh)· October 2025

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Rats subject to extracorporeal membrane oxygenation have improved cardiac function following anticoagulation and reversal with factor IXa aptamer-antidote oligonucleotide pair.
Shahid M Nimjee, Fellery de Lange, George A Pitoc, Bruce A Sullenger

Cardiol Plus· June 2025

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Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors.
Haixiang Yu, Shekhar Kumar, James W Frederiksen, Vladimir N Kolyadko, George Pitoc

Nat Commun· May 2024

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PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response.
Imran Ozer, George A Pitoc, Juliana M Layzer, Angelo Moreno, Lyra B Olson

Adv Mater· March 2022

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Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.
Shahid M Nimjee, David Dornbos, George A Pitoc, Debra G Wheeler, Juliana M Layzer

Mol Ther· July 2019

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Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers.
Angelo Moreno, George A Pitoc, Nancy J Ganson, Juliana M Layzer, Michael S Hershfield

Cell Chem Biol· May 2019

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Probing the coagulation pathway with aptamers identifies combinations that synergistically inhibit blood clot formation.
Kristin M Bompiani, Jens L Lohrmann, George A Pitoc, James W Frederiksen, George B Mackensen

Chem Biol· August 2014

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Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses.
Eda K Holl, Kara L Shumansky, George Pitoc, Elizabeth Ramsburg, Bruce A Sullenger

PLoS One· March 2014

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Nucleic acid scavengers inhibit thrombosis without increasing bleeding.
Shashank Jain, George A Pitoc, Eda K Holl, Ying Zhang, Luke Borst

Proc Natl Acad Sci U S A· August 2012

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Sarcocystis sp. encephalomyelitis in a cat.
Tricia M Bisby, Patricia J Holman, George A Pitoc, Rebecca A Packer, Craig A Thompson

Vet Clin Pathol· March 2010

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Antidote-mediated control of an anticoagulant aptamer in vivo.
Christopher P Rusconi, Joseph D Roberts, George A Pitoc, Shahid M Nimjee, Rebekah R White

Nat Biotechnol· November 2004

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Mutations within a conserved protein kinase A recognition sequence confer temperature-sensitive and partially defective activities onto mouse c-Rel.
Maria-Emily R Gapuzan, George A Pitoc, Thomas D Gilmore

Biochem Biophys Res Commun· July 2003

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RNA aptamers as reversible antagonists of coagulation factor IXa.
Christopher P Rusconi, Elizabeth Scardino, Juliana Layzer, George A Pitoc, Thomas L Ortel

Nature· September 2002

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