Publications by authors named "George Sharbeen"

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CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts.
Shannon Chiang, Keilah Garcia Netto, John Kokkinos, Koroush S Haghighi, Aparna S Raina, George Sharbeen

Sci Rep· July 2025

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Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells.
Rosa Mistica C Ignacio, Helen Forgham, Zerong Ma, Anya Jensen, George Sharbeen

Cell Commun Signal· June 2025

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MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability.
James Ephraums, Janet Youkhana, Aparna S Raina, Grace Schulstad, Kento Croft, George Sharbeen

Neoplasia· March 2025

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Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer-Associated Fibroblasts.
Richard Tang, Szun S Tay, George Sharbeen, David Herrmann, Janet Youkhana

Eur J Immunol· February 2025

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Development of a long term, ex vivo, patient-derived explant model of endometrial cancer.
Hannah van der Woude, Khoi Phan, Diane N Kenwright, Louise Goossens, Kathryn Elizabeth Hally, George Sharbeen

PLoS One· April 2024

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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.
Jessica L Chitty, Michelle Yam, Lara Perryman, Amelia L Parker, Joanna N Skhinas, George Sharbeen

Nat Cancer· September 2023

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How to exploit different endocytosis pathways to allow selective delivery of anticancer drugs to cancer cells over healthy cells.
Vu Thanh Cong, Richard D Tilley, George Sharbeen, Phoebe A Phillips, Katharina Gaus

Chem Sci· December 2021

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ROR1 and ROR2 expression in pancreatic cancer.
Dongli Liu, George Sharbeen, Phoebe Phillips, , Caroline E Ford

BMC Cancer· November 2021

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Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition.
George Sharbeen, Joshua A McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana

Cancer Res· July 2021

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Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells.
Stephanie Nemec, Joey Lam, Jingxiao Zhong, Celine Heu, Paul Timpson, George Sharbeen

Adv Biol (Weinh)· June 2021

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Does the Microenvironment Hold the Hidden Key for Functional Precision Medicine in Pancreatic Cancer?
John Kokkinos, Anya Jensen, George Sharbeen, Joshua A McCarroll, David Goldstein

Cancers (Basel)· May 2021

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Ex vivo culture of intact human patient derived pancreatic tumour tissue.
John Kokkinos, George Sharbeen, Koroush S Haghighi, Rosa Mistica C Ignacio, Chantal Kopecky

Sci Rep· January 2021

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Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs.
John Kokkinos, Rosa Mistica C Ignacio, George Sharbeen, Cyrille Boyer, Estrella Gonzales-Aloy

Biomaterials· May 2020

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Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery.
Kristel C Tjandra, Nigel McCarthy, Lu Yang, Alistair J Laos, George Sharbeen

J Med Chem· March 2020

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The Use of Star Polymer Nanoparticles for the Delivery of siRNA to Mouse Orthotopic Pancreatic Tumor Models.
Joshua A McCarroll, George Sharbeen, Maria Kavallaris, Phoebe A Phillips

Methods Mol Biol· November 2019

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Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.
Eddy Sanchai Thientosapol, George Sharbeen, K K Edwin Lau, Daniel Bosnjak, Timothy Durack

Nucleic Acids Res· April 2017

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MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity.
George Sharbeen, Janet Youkhana, Amanda Mawson, Joshua McCarroll, Andrea Nunez

Oncotarget· February 2017

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A Rationally Optimized Nanoparticle System for the Delivery of RNA Interference Therapeutics into Pancreatic Tumors in Vivo.
Joann Teo, Joshua A McCarroll, Cyrille Boyer, Janet Youkhana, Sharon M Sagnella, George Sharbeen

Biomacromolecules· July 2016

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Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer.
George Sharbeen, Joshua McCarroll, David Goldstein, Phoebe A Phillips

Front Nutr· May 2015

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Correction to "effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers".
Cyrille Boyer, Joann Teo, Phoebe Phillips, Rafael B Erlich, Sharon Sagnella, George Sharbeen

Mol Pharm· March 2015

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βIII-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer.
Joshua A McCarroll, George Sharbeen, Jie Liu, Janet Youkhana, David Goldstein

Oncotarget· February 2015

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Role of pancreatic stellate cells in chemoresistance in pancreatic cancer.
Joshua A McCarroll, Stephanie Naim, George Sharbeen, Nelson Russia, Julia Lee

Front Physiol· June 2014

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Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers.
Cyrille Boyer, Joann Teo, Phoebe Phillips, Rafael B Erlich, Sharon Sagnella, George Sharbeen

Mol Pharm· June 2013

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Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase.
George Sharbeen, Christine W Y Yee, Adrian L Smith, Christopher J Jolly

J Exp Med· May 2012

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A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling.
Tsun-Wen Yao, Woo-Shin Kim, Denise M T Yu, George Sharbeen, Geoffrey W McCaughan

Mol Cancer Res· July 2011

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