Publications by authors named "George Simos"

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Oxygen-independent expression of HIF-1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia.
Ioanna-Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos

FEBS J· November 2025

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Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF-dependent activation of hypoxia-inducible genes.
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, George Simos

FEBS J· August 2025

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Combinatorial regulation by ERK1/2 and CK1δ protein kinases leads to HIF-1α association with microtubules and facilitates its symmetrical distribution during mitosis.
Christina Arseni, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis

Cell Mol Life Sci· February 2024

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Hypoxia-driven deSUMOylation of EXOSC10 promotes adaptive changes in the transcriptome profile.
Chrysa Filippopoulou, Chairini C Thomé, Sofia Perdikari, Evgenia Ntini, George Simos

Cell Mol Life Sci· January 2024

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Direct interaction between mortalin and HIF-1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax.
Angelos Yfantis, Ilias Mylonis, George Simos

FEBS J· August 2023

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Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia.
Angeliki Karagiota, Amalia Kanoura, Efrosyni Paraskeva, George Simos, Georgia Chachami

FEBS J· April 2023

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Transcriptional Response to Hypoxia: The Role of HIF-1-Associated Co-Regulators.
Angelos Yfantis, Ilias Mylonis, Georgia Chachami, Marios Nikolaidis, Grigorios D Amoutzias, George Simos

Cells· March 2023

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Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling.
Chrysa Taze, Sotiria Drakouli, Martina Samiotaki, George Panayotou, George Simos

Redox Biol· December 2022

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Hepcidin as a Sensitive and Treatment-Responsive Acute-Phase Marker in Patients with Bacteremia: A Pilot Study.
Kreon Koukoulas, Vasiliki Lygoura, Philip Kartalidis, Nikolaos K Gatselis, Efthymia Petinaki, George Simos

Diagnostics (Basel)· June 2022

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ERK signaling controls productive HIF-1 binding to chromatin and cancer cell adaptation to hypoxia through HIF-1α interaction with NPM1.
Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos

Mol Oncol· December 2021

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Erythropoietin levels in children with obstructive sleep apnea.
Nick D Kalogritsas, Vasileios A Lachanas, Panagiotis Liakos, Emmanuel I Alexopoulos, Despoina Beka, George Simos

Int J Pediatr Otorhinolaryngol· December 2021

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Specific Inhibition of HIF Activity: Can Peptides Lead the Way?
Ilias Mylonis, Georgia Chachami, George Simos

Cancers (Basel)· January 2021

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The Role of Sumoylation in the Response to Hypoxia: An Overview.
Chrysa Filippopoulou, George Simos, Georgia Chachami

Cells· October 2020

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Hypoxia Induces Pro-Fibrotic and Fibrosis Marker Genes in Hepatocellular Carcinoma Cells Independently of Inflammatory Stimulation and the NF-κΒ Pathway.
Eleni-Anastasia Triantafyllou, Ilias Mylonis, George Simos, Efrosyni Paraskeva

Hypoxia (Auckl)· December 2019

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Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.
Georgia Chachami, Nicolas Stankovic-Valentin, Angeliki Karagiota, Angeliki Basagianni, Uwe Plessmann, George Simos

Mol Cell Proteomics· June 2019

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ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling.
Ioanna-Maria Gkotinakou, Christina Befani, George Simos, Panagiotis Liakos

J Cell Sci· April 2019

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Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity.
Angeliki Karagiota, Ilias Mylonis, George Simos, Georgia Chachami

Arch Biochem Biophys· March 2019

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Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism.
Ilias Mylonis, George Simos, Efrosyni Paraskeva

Cells· March 2019

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HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia.
Angeliki Karagiota, Maria Kourti, George Simos, Ilias Mylonis

Cell Mol Life Sci· February 2019

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Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.
Eleni-Anastasia Triantafyllou, Eleni Georgatsou, Ilias Mylonis, George Simos, Efrosyni Paraskeva

Biochim Biophys Acta Mol Cell Biol Lipids· September 2018

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Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
Jothilatha Krishnamoorthy, Clara Tenkerian, Jyotsana Gupta, Nour Ghaddar, Shuo Wang, George Simos

Cell Death Dis· February 2018

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Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia.
Ilias Mylonis, Maria Kourti, Martina Samiotaki, George Panayotou, George Simos

J Cell Sci· January 2017

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HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia.
Evanthia Pangou, Christina Befani, Ilias Mylonis, Martina Samiotaki, George Panayotou, George Simos

J Cell Sci· November 2016

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Low Serum Hepcidin in Patients with Autoimmune Liver Diseases.
Aggeliki Lyberopoulou, Georgia Chachami, Nikolaos K Gatselis, Eleni Kyratzopoulou, Asterios Saitis, George Simos

PLoS One· May 2016

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HIF-1α in colorectal carcinoma: review of the literature.
Maria Ioannou, Efrosyni Paraskeva, Korina Baxevanidou, George Simos, Roidoula Papamichali

J BUON· August 2015

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