Publications by authors named "Georgy Hartmann"

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Developing a mechanistic understanding of the nonlinear pharmacokinetics of letermovir and prospective drug interaction with everolimus using physiological-based pharmacokinetic modeling.
Karsten Menzel, Yuhsin Kuo, Dapeng Chen, Georgy Hartmann, Ying-Hong Wang

Clin Transl Sci· June 2023

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Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
Petr Vachal, Joseph L Duffy, Louis-Charles Campeau, Rupesh P Amin, Kaushik Mitra, Georgy Hartmann

J Med Chem· September 2021

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Application of Physiologically Based Pharmacokinetic Modeling to Predict Pharmacokinetics in Healthy Japanese Subjects.
Yuki Matsumoto, Tamara Cabalu, Punam Sandhu, Georgy Hartmann, Takashi Iwasa

Clin Pharmacol Ther· April 2019

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Characterization of Anacetrapib Distribution into the Lipid Droplet of Adipose Tissue in Mice and Human Cultured Adipocytes.
Douglas G Johns, Lauretta LeVoci, Mihajlo Krsmanovic, Min Lu, Georgy Hartmann

Drug Metab Dispos· March 2019

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PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product Labeling.
Ying-Hong Wang, Dapeng Chen, Georgy Hartmann, Carolyn R Cho, Karsten Menzel

Clin Pharmacol Ther· February 2019

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Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice.
Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein

Drug Metab Dispos· March 2016

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Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.
Eugene Y Tan, Georgy Hartmann, Qing Chen, Antonio Pereira, Scott Bradley

Drug Metab Dispos· March 2010

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Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans.
Sanjeev Kumar, Eugene Y Tan, Georgy Hartmann, Zachary Biddle, Arthur J Bergman

Drug Metab Dispos· March 2010

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Impact of endotoxin-induced changes in P-glycoprotein expression on disposition of doxorubicin in mice.
Georgy Hartmann, Vessela Vassileva, Micheline Piquette-Miller

Drug Metab Dispos· June 2005

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Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.
Kerry B Goralski, Georgy Hartmann, Micheline Piquette-Miller, Kenneth W Renton

Br J Pharmacol· May 2003

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Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.
W James Gilmore, Georgy Hartmann, Micheline Piquette-Miller, Jason Marriott, Gordon M Kirby

Toxicology· March 2003

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Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.
Georgy Hartmann, Annie K Y Cheung, Micheline Piquette-Miller

J Pharmacol Exp Ther· October 2002

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