Publications by authors named "David Gutstein"

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Efficacy and safety of REGN9933 and REGN7508 for preventing postoperative venous thromboembolism (ROXI-VTE-I and ROXI-VTE-II): two randomised, open-label, phase 2 trials.
Jeffrey I Weitz, Aaron P Kithcart, Meagan P O'Brien, Oren Levy, Ethan Marin, David E Gutstein

Lancet· November 2025

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Nexiguran Ziclumeran Gene Editing in Hereditary ATTR with Polyneuropathy.
Julian D Gillmore, Ed Gane, Jörg Täubel, Björn Pilebro, Andoni Echaniz-Laguna, David E Gutstein

N Engl J Med· October 2025

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Operationalising a Haemophilia Gene Editing Lexicon for Practical Use.
William McKeown, Cedric Hermans, Carmen Unzu, Mark A Kay, Flora Peyvandi, David E Gutstein

Haemophilia· March 2025

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Development of a novel gene editing lexicon for hemophilia: methodology and results.
Craig M Kessler, Leonard A Valentino, Courtney D Thornburg, Carmen Unzu, Mark A Kay, David E Gutstein

Res Pract Thromb Haemost· February 2025

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CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy.
Marianna Fontana, Scott D Solomon, Jessica Kachadourian, Liron Walsh, Ricardo Rocha, David E Gutstein

N Engl J Med· December 2024

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Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension.
Olivier Boucherat, Tetsuro Yokokawa, Vinod Krishna, Shanker Kalyana-Sundaram, Sandra Martineau, David Gutstein

Nat Cardiovasc Res· August 2022

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Gaining Efficiency in Clinical Trials With Cardiac Biomarkers: JACC Review Topic of the Week.
James L Januzzi, John M Canty, Saumya Das, Christopher R DeFilippi, Gary A Gintant, David E Gutstein

J Am Coll Cardiol· April 2021

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Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach.
Karima Habbout, Junichi Omura, Charifa Awada, Alice Bourgeois, Yann Grobs, David Gutstein

Int J Mol Sci· March 2021

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A Study to Assess the Proarrhythmic Potential of Mirtazapine Using Concentration-QTc (C-QTc) Analysis.
Sevgi Gurkan, Fang Liu, Anne Chain, David E Gutstein

Clin Pharmacol Drug Dev· May 2019

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Pharmacokinetics and Pharmacodynamics of Anacetrapib in Black and White Healthy Subjects.
Rajesh Krishna, Ferdous Gheyas, Christy Corr, Josee Cote, Yang Liu, David E Gutstein

J Clin Pharmacol· December 2018

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Surface State Dynamics Dictating Transport in InAs Nanowires.
David Lynall, Selvakumar V Nair, David Gutstein, Alexander Shik, Igor G Savelyev

Nano Lett· February 2018

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Pharmacokinetics of sugammadex in subjects with moderate and severe renal impairment
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K Chris Min, Kenneth C Lasseter, Thomas C Marbury, Rebecca E Wrishko, William D Hanley, David E Gutstein

Int J Clin Pharmacol Ther· September 2017

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CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects.
Tiffany Thomas, Haihong Zhou, Wahida Karmally, Rajasekhar Ramakrishnan, Stephen Holleran, David E Gutstein

Arterioscler Thromb Vasc Biol· September 2017

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Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E.
John S Millar, Michael E Lassman, Tiffany Thomas, Rajasekhar Ramakrishnan, Patricia Jumes, David E Gutstein

J Lipid Res· June 2017

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Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Deborah A Howatt, Maya Dajee, Xiaojie Xie, Jessica Moorleghen, Debra L Rateri, David E Gutstein

Circ J· May 2017

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Factor XIIa as a Novel Target for Thrombosis: Target Engagement Requirement and Efficacy in a Rabbit Model of Microembolic Signals.
Christopher M Barbieri, Xinkang Wang, Weizhen Wu, Xueping Zhou, Aimie M Ogawa, David E Gutstein

J Pharmacol Exp Ther· March 2017

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Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
Xinkang Wang, Stan Kurowski, Weizhen Wu, Gino A Castriota, Xueping Zhou, David E Gutstein

J Pharmacol Exp Ther· March 2017

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Apixaban Inhibits Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
Xueping Zhou, Weizhen Wu, Lin Chu, David E Gutstein, Dietmar Seiffert

J Pharmacol Exp Ther· September 2016

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Discovery and Clinical Evaluation of MK-8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release.
Clayton D Knox, Pieter-Jan de Kam, Karim Azer, Peggy Wong, Antwan G Ederveen, David E Gutstein

J Am Heart Assoc· August 2016

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Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein.
Gissette Reyes-Soffer, John S Millar, Colleen Ngai, Patricia Jumes, Ellie Coromilas, David E Gutstein

Arterioscler Thromb Vasc Biol· May 2016

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Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.
John S Millar, Gissette Reyes-Soffer, Patricia Jumes, Richard L Dunbar, Emil M deGoma, David E Gutstein

J Clin Invest· April 2016

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Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice.
Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein

Drug Metab Dispos· March 2016

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Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.
John S Millar, Gissette Reyes-Soffer, Patricia Jumes, Richard L Dunbar, Emil M deGoma, David E Gutstein

J Clin Invest· June 2015

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Lack of a clinically relevant effect of sugammadex on anti-Xa activity or activated partial thromboplastin time following pretreatment with either unfractionated or low-molecular-weight heparin in healthy subjects.
Pieter-Jan De Kam, Annelieke C Kruithof, Marie-José van Lierop, Matthijs Moerland, Justin Dennie, David E Gutstein

Int J Clin Pharmacol Ther· August 2014

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