Publications by authors named "Gerald J Roth"

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Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
Christian A Kuttruff, Marco Ferrara, Tom Bretschneider, Stefan Hoerer, Sandra Handschuh, Gerald J Roth

ACS Med Chem Lett· December 2017

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Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.
Gerald J Roth, Armin Heckel, Jörg T Kley, Thorsten Lehmann, Stephan G Müller

Bioorg Med Chem Lett· August 2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.
Thorsten Oost, Armin Heckel, Jörg T Kley, Thorsten Lehmann, Stephan Müller, Gerald J Roth

Bioorg Med Chem Lett· August 2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.
Stephan G Müller, Armin Heckel, Jörg T Kley, Thorsten Lehmann, Philipp Lustenberger, Gerald J Roth

Bioorg Med Chem Lett· August 2015

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Nintedanib: from discovery to the clinic.
Gerald J Roth, Rudolf Binder, Florian Colbatzky, Claudia Dallinger, Rozsa Schlenker-Herceg

J Med Chem· February 2015

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Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.
Patrick Baum, Ramona Schmid, Carina Ittrich, Werner Rust, Katrin Fundel-Clemens, Gerald J Roth

PLoS One· December 2010

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Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI).
Gerald J Roth, Armin Heckel, Trixi Brandl, Matthias Grauert, Stefan Hoerer

J Med Chem· October 2010

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Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).
Gerald J Roth, Armin Heckel, Florian Colbatzky, Sandra Handschuh, Jörg Kley

J Med Chem· July 2009

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Bortezomib, dexamethasone, and fibroblast growth factor receptor 3-specific tyrosine kinase inhibitor in t(4;14) myeloma.
Guido Bisping, Doris Wenning, Martin Kropff, Dirk Gustavus, Carsten Müller-Tidow, Gerald J Roth

Clin Cancer Res· January 2009

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BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
Frank Hilberg, Gerald J Roth, Martin Krssak, Susanna Kautschitsch, Wolfgang Sommergruber

Cancer Res· June 2008

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Paracrine interactions of vascular endothelial growth factor and platelet-derived growth factor in endothelial and lung cancer cells.
Niels Reinmuth, Sonja Rensinghoff, Miriam Raedel, Nicole Fehrmann, Christian Schwöppe, Gerald J Roth

Int J Oncol· September 2007

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Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors.
Emma Kulimova, Elisabeth Oelmann, Guido Bisping, Joachim Kienast, Rolf M Mesters, Gerald J Roth

Mol Cancer Ther· December 2006

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Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.
Guido Bisping, Martin Kropff, Doris Wenning, Britta Dreyer, Sergey Bessonov, Gerald J Roth

Blood· March 2006

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The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts.
Junhui Zou, Hitoshi Ichikawa, Michael L Blackburn, Hsien-Ming Hu, Anna Zielinska-Kwiatkowska, Gerald J Roth

Mol Cell Biol· July 2005

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