Publications by authors named "Thorsten Oost"

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Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer.
Christian A Kuttruff, Martin Fleck, Sebastian Carotta, Heribert Arnhof, Tom Bretschneider, Thorsten Oost

J Med Chem· July 2023

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Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists.
Hervé Geneste, Swati Bhowmik, Marcel M van Gaalen, Wilfried Hornberger, Charles W Hutchins, Thorsten Oost

Bioorg Med Chem Lett· October 2018

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Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.
Gerald J Roth, Armin Heckel, Jörg T Kley, Thorsten Lehmann, Stephan G Müller, Thorsten Oost

Bioorg Med Chem Lett· August 2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.
Thorsten Oost, Armin Heckel, Jörg T Kley, Thorsten Lehmann, Stephan Müller

Bioorg Med Chem Lett· August 2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.
Stephan G Müller, Armin Heckel, Jörg T Kley, Thorsten Lehmann, Philipp Lustenberger, Thorsten Oost

Bioorg Med Chem Lett· August 2015

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Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties.
Thorsten Oost, Gisela Backfisch, Swati Bhowmik, Marcel M van Gaalen, Hervé Geneste

Bioorg Med Chem Lett· June 2011

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Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
Andrew M Petros, Jeffrey R Huth, Thorsten Oost, Cheol-Min Park, Hong Ding

Bioorg Med Chem Lett· November 2010

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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Milan Bruncko, Thorsten K Oost, Barbara A Belli, Hong Ding, Mary K Joseph

J Med Chem· February 2007

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Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
Michael D Wendt, Wang Shen, Aaron Kunzer, William J McClellan, Milan Bruncko, Thorsten K Oost

J Med Chem· February 2006

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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Thorsten K Oost, Chaohong Sun, Robert C Armstrong, Ali-Samer Al-Assaad, Stephen F Betz

J Med Chem· August 2004

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Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease.
Thorsten Oost, Chanokporn Sukonpan, Matthias Brewer, Michael Goodnough, William Tepp

Biopolymers· April 2004

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Potent, selective inhibitors of protein tyrosine phosphatase 1B.
Zhili Xin, Thorsten K Oost, Cele Abad-Zapatero, Philip J Hajduk, Zhonghua Pei

Bioorg Med Chem Lett· June 2003

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Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA.
Liping Yu, Thorsten K Oost, Jeffrey M Schkeryantz, Jianguo Yang, Dave Janowick

J Am Chem Soc· April 2003

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Sequencing hydroxyethylamine-containing peptides via Edman degradation.
Matthias Brewer, Thorsten Oost, Chanokporn Sukonpan, Michaela Pereckas, Daniel H Rich

Org Lett· October 2002

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