Publications by authors named "Michael D Wendt"

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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X Inhibitor.
Le Wang, George A Doherty, Andrew S Judd, Zhi-Fu Tao, T Matthew Hansen, Michael D Wendt

ACS Med Chem Lett· October 2020

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Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor.
Yi-Yin Ku, Vincent S Chan, Alan Christesen, Timothy Grieme, Mathew Mulhern, Michael D Wendt

J Org Chem· April 2019

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Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.
David A DeGoey, Hui-Ju Chen, Philip B Cox, Michael D Wendt

J Med Chem· April 2018

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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
Le Wang, John K Pratt, Todd Soltwedel, George S Sheppard, Steven D Fidanze, Michael D Wendt

J Med Chem· May 2017

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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Joel D Leverson, Darren C Phillips, Michael J Mitten, Erwin R Boghaert, Dolores Diaz, Michael D Wendt

Sci Transl Med· March 2015

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Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Andrew M Petros, Steven L Swann, Danying Song, Kerren Swinger, Chang Park, Michael D Wendt

Bioorg Med Chem Lett· March 2014

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
Andrew J Souers, Joel D Leverson, Erwin R Boghaert, Scott L Ackler, Nathaniel D Catron, Michael D Wendt

Nat Med· February 2013

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Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.
Cheol-Min Park, Milan Bruncko, Jessica Adickes, Joy Bauch, Hong Ding, Michael D Wendt

J Med Chem· November 2008

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Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction.
Michael D Wendt

Expert Opin Drug Discov· September 2008

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Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Jeffrey R Huth, Chang Park, Andrew M Petros, Aaron R Kunzer, Michael D Wendt

Chem Biol Drug Des· July 2007

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Discovery of a novel small molecule binding site of human survivin.
Michael D Wendt, Chaohong Sun, Aaron Kunzer, Daryl Sauer, Kathy Sarris

Bioorg Med Chem Lett· June 2007

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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Milan Bruncko, Thorsten K Oost, Barbara A Belli, Hong Ding, Mary K Joseph, Michael D Wendt

J Med Chem· February 2007

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Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
Michael D Wendt, Wang Shen, Aaron Kunzer, William J McClellan, Milan Bruncko

J Med Chem· February 2006

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Tilman Oltersdorf, Steven W Elmore, Alexander R Shoemaker, Robert C Armstrong, David J Augeri, Michael D Wendt

Nature· June 2005

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Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.
Milan Bruncko, William J McClellan, Michael D Wendt, Daryl R Sauer, Andrew Geyer

Bioorg Med Chem Lett· January 2005

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Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Michael D Wendt, Andrew Geyer, William J McClellan, Todd W Rockway, Moshe Weitzberg

Bioorg Med Chem Lett· June 2004

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Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
Michael D Wendt, Todd W Rockway, Andrew Geyer, William McClellan, Moshe Weitzberg

J Med Chem· January 2004

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Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment.
William R Roush, Thomas D Bannister, Michael D Wendt, Jill A Jablonowski, Karl A Scheidt

J Org Chem· June 2002

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An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones.
William R Roush, Thomas D Bannister, Michael D Wendt, Michael S VanNieuwenhze, Darin J Gustin

J Org Chem· June 2002

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Total synthesis of (-)-bafilomycin A(1).
Karl A Scheidt, Thomas D Bannister, Akihiro Tasaka, Michael D Wendt, Brad M Savall

J Am Chem Soc· June 2002

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Total Synthesis of (-)-Bafilomycin A : Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions.
Karl A Scheidt, Akihiro Tasaka, Thomas D Bannister, Michael D Wendt, William R Roush

Angew Chem Int Ed Engl· June 1999

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