Publications by authors named "Mathew Mulhern"

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Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor.
Yi-Yin Ku, Vincent S Chan, Alan Christesen, Timothy Grieme, Mathew Mulhern

J Org Chem· April 2019

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Improved synthesis of 3-substituted-4-amino-[3,2-c]-thienopyridines.
Kenneth M Engstrom, Amanda L Baize, Thaddeus S Franczyk, Jeffrey M Kallemeyn, Mathew M Mulhern

J Org Chem· May 2009

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Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.
Gang Zhao, Andrew J Souers, Martin Voorbach, H Doug Falls, Brian Droz, Mathew M Mulhern

J Med Chem· February 2008

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Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.
Andrew S Judd, Andrew J Souers, Dariusz Wodka, Gang Zhao, Mathew M Mulhern

Bioorg Med Chem Lett· April 2007

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Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Andrew J Souers, Rajesh R Iyengar, Andrew S Judd, David W A Beno, Ju Gao, Mathew M Mulhern

Bioorg Med Chem Lett· February 2007

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An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.
Rajesh R Iyengar, John K Lynch, Mathew M Mulhern, Andrew S Judd, Jennifer C Freeman

Bioorg Med Chem Lett· February 2007

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Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Zhonghua Pei, Xiaofeng Li, Thomas W von Geldern, David J Madar, Kenton Longenecker, Mathew Mulhern

J Med Chem· November 2006

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Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.
John K Lynch, Jennifer C Freeman, Andrew S Judd, Rajesh Iyengar, Mathew Mulhern

J Med Chem· November 2006

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Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.
Philip R Kym, Andrew J Souers, Thomas J Campbell, John K Lynch, Andrew S Judd, Mathew Mulhern

J Med Chem· April 2006

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Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.
Anil Vasudevan, Andrew J Souers, Jennifer C Freeman, Mary K Verzal, Ju Gao, Mathew M Mulhern

Bioorg Med Chem Lett· December 2005

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Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists.
Philip R Kym, Rajesh Iyengar, Andrew J Souers, John K Lynch, Andrew S Judd, Mathew Mulhern

J Med Chem· September 2005

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Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Andrew J Souers, Ju Gao, Dariusz Wodka, Andrew S Judd, Mathew M Mulhern

Bioorg Med Chem Lett· June 2005

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Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.
Andrew J Souers, Ju Gao, Michael Brune, Eugene Bush, Dariusz Wodka, Mathew Mulhern

J Med Chem· March 2005

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