Publications by authors named "Rajesh Iyengar"

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The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system.
Susana S Correia, Guang Liu, Sarah Jacobson, Sylvie G Bernier, Jenny V Tobin, Rajesh R Iyengar

J Neuroinflammation· September 2021

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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator.
Glen R Rennie, Timothy C Barden, Sylvie G Bernier, Andrew Carvalho, Renee Deming, Rajesh R Iyengar

Bioorg Med Chem Lett· May 2021

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The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases.
Susana S Correia, Rajesh R Iyengar, Peter Germano, Kim Tang, Sylvie G Bernier

Front Pharmacol· May 2021

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Utility of the APACHE IV, PPI, and combined APACHE IV with PPI for predicting overall and disease-specific ICU and ACU mortality.
Jennifer A Burkmar, Rajesh Iyengar

Am J Hosp Palliat Care· August 2011

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APACHE IV versus PPI for predicting community hospital ICU mortality.
Shaffer R Shrope-Mok, Katie A Propst, Rajesh Iyengar

Am J Hosp Palliat Care· June 2010

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Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.
Gang Zhao, Andrew J Souers, Martin Voorbach, H Doug Falls, Brian Droz, Rajesh R Iyengar

J Med Chem· February 2008

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Lead optimization strategies and tactics applied to the discovery of melanin concentrating hormone receptor 1 antagonists.
Philip R Kym, Andrew S Judd, John K Lynch, Rajesh Iyengar, Anil Vasudevan

Curr Top Med Chem· November 2007

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Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.
Gang Zhao, Rajesh R Iyengar, Andrew S Judd, Barbara Cool, William Chiou

Bioorg Med Chem Lett· June 2007

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Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.
Andrew S Judd, Andrew J Souers, Dariusz Wodka, Gang Zhao, Mathew M Mulhern, Rajesh R Iyengar

Bioorg Med Chem Lett· April 2007

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Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Andrew J Souers, Rajesh R Iyengar, Andrew S Judd, David W A Beno, Ju Gao

Bioorg Med Chem Lett· February 2007

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An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.
Rajesh R Iyengar, John K Lynch, Mathew M Mulhern, Andrew S Judd, Jennifer C Freeman

Bioorg Med Chem Lett· February 2007

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Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.
John K Lynch, Jennifer C Freeman, Andrew S Judd, Rajesh Iyengar, Mathew Mulhern

J Med Chem· November 2006

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Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety.
Ana M Basso, Natalie A Bratcher, Kelly B Gallagher, Marlon D Cowart, Chen Zhao, Rajesh Iyengar

Eur J Pharmacol· July 2006

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Barbara Cool, Bradley Zinker, William Chiou, Lemma Kifle, Ning Cao, Rajesh Iyengar

Cell Metab· June 2006

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Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.
Philip R Kym, Andrew J Souers, Thomas J Campbell, John K Lynch, Andrew S Judd, Rajesh Iyengar

J Med Chem· April 2006

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Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine.
Rajesh Iyengar, Klaas Schildknegt, Martha Morton, Jeffrey Aubé

J Org Chem· December 2005

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Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists.
Philip R Kym, Rajesh Iyengar, Andrew J Souers, John K Lynch, Andrew S Judd

J Med Chem· September 2005

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Tandem 5 + 2/3 + 2 and 5 + 2/3 + 3 Cycloaddition Reactions.
Thomas A. Engler, Cynthia M. Scheibe, Rajesh Iyengar

J Org Chem· November 1997

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