Publications by authors named "Gerald Shipps"

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MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
Sobhana Babu Boga, Yongqi Deng, Liang Zhu, Yang Nan, Alan B Cooper, Gerald W Shipps

ACS Med Chem Lett· July 2018

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Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.
Sobhana Babu Boga, Abdul-Basit Alhassan, Alan B Cooper, Ronald Doll, Neng-Yang Shih, Gerald Shipps

Bioorg Med Chem Lett· June 2018

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Corrigendum to "1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents" [Bioorg. Med. Chem. Lett. 27 (2017) 4471-4477].
Alan B Cooper, Stephane Ciblat, Gerald Shipps, Jedd Levine, Matthew Kostura

Bioorg Med Chem Lett· March 2018

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Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.
Stergios J Moschos, Ryan J Sullivan, Wen-Jen Hwu, Ramesh K Ramanathan, Alex A Adjei, Gerald W Shipps

JCI Insight· February 2018

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1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents.
Alan B Cooper, Stephane Ciblat, Gerald Shipps, Jedd Levine, Matthew Kostura

Bioorg Med Chem Lett· September 2017

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Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.
Yuan Tian, Yao Ma, Craig R Gibeau, Brian R Lahue, Gerald W Shipps

Bioorg Med Chem Lett· June 2016

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Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Stéphane L Bogen, Weidong Pan, Craig R Gibeau, Brian R Lahue, Yao Ma, Gerald W Shipps

ACS Med Chem Lett· March 2016

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Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.
Yongqi Deng, Gerald W Shipps, Alan Cooper, Jessie M English, D Allen Annis

J Med Chem· November 2014

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Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor.
Yao Ma, Brian R Lahue, Craig R Gibeau, Gerald W Shipps, Stéphane L Bogen

ACS Med Chem Lett· May 2014

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Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.
Weidong Pan, Brian R Lahue, Yao Ma, Latha G Nair, Gerald W Shipps

Bioorg Med Chem Lett· April 2014

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Substituted piperidines as HDM2 inhibitors.
Yao Ma, Brian R Lahue, Gerald W Shipps, Jeseca Brookes, Yaolin Wang

Bioorg Med Chem Lett· February 2014

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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor.
Yongqi Deng, Gerald W Shipps, Lianyun Zhao, M Arshad Siddiqui, Janeta Popovici-Muller

Bioorg Med Chem Lett· January 2014

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Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
Erick J Morris, Sharda Jha, Clifford R Restaino, Priya Dayananth, Hugh Zhu, Gerald Shipps

Cancer Discov· July 2013

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Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.
Xiaohua Huang, Cliff C Cheng, Thierry O Fischmann, José S Duca, Matthew Richards, Gerald W Shipps

Bioorg Med Chem Lett· May 2013

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Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Yongqi Deng, Zhiwei Yang, Gerald W Shipps, Sie-Mun Lo, Robert West

Bioorg Med Chem Lett· February 2013

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Application of affinity selection-mass spectrometry assays to purification and affinity-based screening of the chemokine receptor CXCR4.
Charles E Whitehurst, Zhiping Yao, Denise Murphy, Mingxuan Zhang, Shane Taremi, Gerald W Shipps

Comb Chem High Throughput Screen· July 2012

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Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode.
Xiaohua Huang, Cliff C Cheng, Thierry O Fischmann, José S Duca, Xianshu Yang, Gerald W Shipps

ACS Med Chem Lett· February 2012

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Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Hongbo Zeng, David B Belanger, Patrick J Curran, Gerald W Shipps, Hua Miao

Bioorg Med Chem Lett· October 2011

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Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.
Xiaohua Huang, Gerald W Shipps, Cliff C Cheng, Peter Spacciapoli, Xingmin Zhang

ACS Med Chem Lett· August 2011

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Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism.
Laura F Silvian, Jessica E Friedman, Kathy Strauch, Teresa G Cachero, Eric S Day, Gerald W Shipps

ACS Chem Biol· June 2011

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Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity.
Hong Lan, Cliff C Cheng, Timothy J Kowalski, Ling Pang, Lixin Shan, Gerald W Shipps

J Lipid Res· April 2011

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Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase.
Cliff C Cheng, Xiaohua Huang, Gerald W Shipps, Yu-Sen Wang, Daniel F Wyss

ACS Med Chem Lett· December 2010

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Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.
Payal R Sheth, Gerald W Shipps, Wolfgang Seghezzi, Catherine K Smith, Cheng-Chi Chuang

Biochemistry· September 2010

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Structure and activity relationships of tartrate-based TACE inhibitors.
Dansu Li, Janeta Popovici-Muller, David B Belanger, John Caldwell, Chaoyang Dai, Gerald W Shipps

Bioorg Med Chem Lett· August 2010

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Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Cliff C Cheng, Gerald W Shipps, Zhiwei Yang, Noriyuki Kawahata, Charles A Lesburg

Bioorg Med Chem Lett· April 2010

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